Repair of Damaged Bases

Britt, Anne B.

doi:10.1199/tab.0005

Cited by 33 publications

(29 citation statements)

References 73 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies in plants mainly involving Arabidopsis have identified structural and/or functional homologs of most of the BER proteins in plant genome (Britt, 2002;García-Ortiz et al, 2001;Kimura & Sakaguchi, 2006;. In plants, the general knowledge about Pol λ structure and functions is still limited.…”

Section: Is Pol λ Involved In Plant's Ber?mentioning

confidence: 99%

“…Mammalian Pol λ is an exonuclease-deficient, 575-amino acid single polypeptide DNA polymerase (García-Diaz et al, 2000, 2002Ramadan, Shevelev, & Hübscher, 2004) which has been found to share high degree of sequence homology with mammalian Pol β (32% 142 amino acid identity). In mammals, a plethora of studies have demonstrated the involvement of Pol λ in all the three major repair pathways including BER (Garcia-Ortiz, Ariza, & Roldan-Arjona, 2001), NHEJ (Lee et al, 2004), and TLS (Picher & Blanco, 2007;Maga et al, 2007;Hübscher & Maga, 2011).…”

Section: Oxidative Stress and Reactive Oxygen Speciesmentioning

confidence: 99%

See 1 more Smart Citation

DNA polymerase λ - a novel DNA repair enzyme in higher plant genome

Roy

2014

Plant Sci Today

View full text Add to dashboard Cite

DNA polymerase lambda (Pol λ) is a novel family X DNA polymerase which has been shown to play key role in nuclear DNA repair and meiotic recombination. Recent studies in mammals support function of this enzyme in base excision repair in response to oxidative DNA damage. However, in plants the biological function of Pol λ in oxidative stress response is still largely unknown. This review will survey recent advances in our understanding of role of Pol λ in repair of oxidative DNA damages and its possible potential involvement in plant's base excision repair (BER) pathway in response to oxidative stress.

show abstract

Section: Is Pol λ Involved In Plant's Ber?mentioning

confidence: 99%

Section: Oxidative Stress and Reactive Oxygen Speciesmentioning

confidence: 99%

DNA polymerase λ - a novel DNA repair enzyme in higher plant genome

Roy

2014

Plant Sci Today

View full text Add to dashboard Cite

show abstract

“…Although many organisms repair DNA damage caused by spontaneous deamination of methylated cytosines to thymines with a thymine-specific MUG DNA glycosylase, no MUG homologs are found in the Arabidopsis genome (Britt, 2002). This is especially surprising given the large amounts of 5-methylcytosine found in plant genomes and the fact that spontaneous deamination is not uncommon.…”

Section: Dna Demethylases: Removing Methylationmentioning

confidence: 67%

“…Plants contain a large number of DNA glycosylases, which might have allowed additional functional specialization of these enzymes (Britt, 2002). While HhH-GPD DNA glycosylases are the largest class of glycosylases among all organisms, the DME family appears to be unique to the plant lineage.…”

Section: Dna Demethylases: Removing Methylationmentioning

confidence: 99%

DNA Methylation and Demethylation in Arabidopsis

Gehring

Henikoff

2008

The Arabidopsis Book

View full text Add to dashboard Cite

“…DNA modifications may also disrupt cellular metabolism (Britt 1996;Mitchell & Karentz 1993). Normally, damage due to UV-B radiation is efficiently repaired (Britt 2002), but the enzymatic repair may be retarded in cold regions due to low temperature (Li et al 2002). Therefore, plants in arctic-alpine environments may possibly be more sensitive to an increase in UV-B radiation than plants in warmer areas.…”

Section: Effects Of Uv Radiation On Higher Plantsmentioning

confidence: 99%

Effects of enhanced UV-B radiation and epidermal UV screening in arctic and alpine plants

Nybakken

Bilger

Arctic Alpine Ecosystems and People in a Changing Environment

View full text Add to dashboard Cite

Plants, as sessile organisms dependent on sunlight for their very existence, are often expected to be vulnerable to increasing UV-B radiation. During the last three decades, more than 800 articles have been published concerning UV-effects on plants (ISI database). Studies have been performed at all levels, from cellular investigations to large projects concerning the effects on entire ecosystems. Of the large number, however, less than 5 % of UV-B response studies on plants have been conducted in the field, and even fewer with plants growing in their natural ecosystems . Only about ten studies have been published on the effects on plants from arctic and alpine areas.This chapter focuses on possible negative effects of increased UV-B radiation and protection against UV-B offered by absorbing pigments. The UV-absorbing compounds in higher plants are mainly located in the epidermis of leaves, where they screen damaging radiation before reaching the mesophyll cells. Experiments with mutants of higher plants have shown that the UV-B sensitivity of leaves and whole plants is strongly correlated with the concentrations of constitutive and UV-B induced screening pigments in the epidermis (e.g. Lois and Buchanan 1994;Landry et al. 1995). UV-B screening compounds in higher plants are often phenolics, of which hydroxycinnamic acid esters (HCAs) and flavonoids are of particular importance. HCAs absorb mainly in the UV-B, while the flavonoids have a second major absorption band in the UV-A. An increased concentration of phenolic compounds in higher plants is a common response to

show abstract

Repair of Damaged Bases

Cited by 33 publications

References 73 publications

DNA polymerase λ - a novel DNA repair enzyme in higher plant genome

DNA polymerase λ - a novel DNA repair enzyme in higher plant genome

DNA Methylation and Demethylation in Arabidopsis

Effects of enhanced UV-B radiation and epidermal UV screening in arctic and alpine plants

Contact Info

Product

Resources

About