Repair of Class II Furcation Defects After a Reparative Tissue Graft Obtained From Extraction Sockets Treated With Growth Factors: A Histologic and Histometric Study in Dogs

Abstract

The use of this graft did not show beneficial effects on the repair of acute Class II furcation defects in dogs.

The In Vitro and In Vivo Osteogenic Capability of the Extraction Socket‐Derived Early Healing Tissue

“…The study conducted by Amler 21 supported this hypothesis, confirming that the osteogenic capability of bone marrow that had undergone 2 weeks of healing was stronger than that of mature bone marrow. Soares et al 22 studied periodontal regeneration potentials of healing tissue of extraction sockets for 5 days after a combined application of platelet‐derived growth factor‐BB and insulin‐like growth factor‐I and failed to show a positive result. Failing to choose the tissue from the optimal phase of socket healing was considered to be one main reasons for this outcome.…”

Retraction

“…Studies performed from the benchtop to the clinic have provided exciting possibilities for BMP-2 and IGF-1 to stimulate periodontal tissue repair (Vainio, et al, 1993;Yamaguchi, 1995;King and Hughes, 2001;Xu, et al, 2003;Fujiwara, et al, 2005;Ripamonti, et al, 2005;Popowics, et al, 2005;Soares, et al, 2005;Kaigler, et al, 2006).…”

Demineralized Dentin as a Semi‐Rigid Barrier for Guiding Periodontal Tissue Regeneration

“…Nonetheless, the limited effectiveness of formation of periodontal soft and hard tissues still leaves room for additional improvement. 5,[9][10][11] Potential shortcomings include inadequate properties of currently used absorbable membranes, such as limited rigidity and low osteoconductivity, and occasional membrane exposure. 12 These aspects require additional improvement to better use barrier materials.…”

“…Consequently, additional regenerative strategies, such as the use of biomaterials and growth factors, have been combined with GTR to promote periodontal tissue restoration. Nonetheless, the limited effectiveness of formation of periodontal soft and hard tissues still leaves room for additional improvement 5,9‐11 . Potential shortcomings include inadequate properties of currently used absorbable membranes, such as limited rigidity and low osteoconductivity, and occasional membrane exposure 12 .…”