Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier

Murakami, Narumichi; Saito, Naoto; Takahashi, J.; Ōta, Hiroshi; Horiuchi, Hiroshi; Nawata, Masashi; Okada, Takao; Nozaki, Kazutoshi; Takaoka, Kunio

doi:10.1016/s0142-9612(03)00041-3

Cited by 67 publications

(45 citation statements)

References 15 publications

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“…11. Repair of a periprosthetic bone defect using PLA-DX-PEG/rhBMP-2 composite adherent to the prosthesis (reprinted from [60], with permission from Elsevier) requires copyright permission since we previously published in Biomaterials [60]. A: Twelve weeks after implantation, the implant with rhBMP-2/PLA-DX-PEG showed new bone formation at the defect site.…”

Section: Discussionmentioning

confidence: 99%

“…To address the problem of loosening of the prosthesis, we developed a new prosthesis combined with rhBMP-2/PLA-DX-PEG composite [60]. We tested efficacy of the rhBMP-2-containing prosthesis in reconstructing a bone defect in a canine model where the medial half of the proximal femur was resected to create a defect that was repaired with rhBMP-2/PLA-DX-PEG composite.…”

Section: Development Of a New Artificial Joint That Restores A Bone Dmentioning

confidence: 99%

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Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins

Saito

Murakami

Takahashi

et al. 2005

Advanced Drug Delivery Reviews

112

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Bone morphogenetic proteins (BMP) induce bone formation in vivo, and clinical application in repair of bone fractures and defects is expected.However, appropriate systems to deliver BMP for clinical use need to be developed. We synthesized a new synthetic biodegradable polymer, poly-D,L-lactic acid-para-dioxanon-polyethylene glycol block copolymer (PLA-DX-PEG), to serve as a biocompatible, biodegradable polymer for recombinant human (rh) BMP-2 delivery systems. In animal experiments new bone was efficiently formed and a large bone defect was repaired using PLA-DX-PEG/rhBMP-2 composites. In addition, this new polymer could be used as an injectable delivery system for rhBMP-2. The rhBMP-2/PLA-DX-PEG composites also could be combined with other materials such as hydroxyapatite or titanium. This new synthetic polymer might be used for rhBMP-2 delivery in various clinical situations involving repair of bone, leading to great changes in orthopedic treatment.2

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Section: Discussionmentioning

confidence: 99%

Section: Development Of a New Artificial Joint That Restores A Bone Dmentioning

confidence: 99%

Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins

Saito

Murakami

Takahashi

et al. 2005

Advanced Drug Delivery Reviews

112

View full text Add to dashboard Cite

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“…The Zurich total hip replacement model is a locked prosthesis intended for use in small animals, its rate of complications was reported around 11% (Hummel et al, 2010). Potential benefits from the interlocking system and coating may be the initial stability (which is required for osteoconduction) and the possibility for use in total hip replacement revision cases when osseous resorption, aseptic loosening and fractures are the main concerns (Murakami et al, 2003;Lauer et al, 2009). Reviewing the human complication rate for cementless prosthesis we found that when a bioactive stem coating is performed, aseptic loosening and stress shielding are diminished and the covering prolongs the rate of survival of the prosthesis in the patient (Emans et al, 2009;Pertegas et al, 2010;Mäkelä et al, 2011: Kim et al, 2012Schwarzkopf et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

Arias

Blanco²,

Doretto

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to modify canine coxofemoral prostheses and the clinical evaluation of the implantation. Fifteen canine hips and femora of cadavers were used in order to study the surface points of modification in prostheses and develop a perforation guide. Femoral stems and acetabular components were perforated and coated with biphasic calcium phosphate layer. Twelve young adult male mongrel dogs were implanted with coxofemoral prostheses. Six were operated upon and implanted with cemented canine modular hip prostheses, establishing the control group. The remaining six were implanted with a novel design of cementless porous tricalcic phosphate-hydroxyapatite coated hip prostheses. Clinical and orthopedic performance, complications, and thigh muscular hypotrophy were assessed up to the 120 th post-operatory day. After 120 days, animals with cementless prostheses had similar clinical and orthopedic performance compared to the cemented group despite the increased pain thigh hypotrophy. Animals that underwent cementless hip prosthesis evidenced more pain, compared to animals with cemented hip prosthesis that required longer recuperation time. No luxations, two fractures and two isquiatic neurapraxies were identified in the course of the study.

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“…Além disso, eles se baseiam prioritariamente na combinação das proteínas morfogenéticas com outros tipos de abordagens terapêuticas (ABDALA et al, 2010;BISHOP;EINHORN, 2007;GROENEVELD;BURGER, 2000;ISSA et al, 2012;MURAKAMI et al, 2003;STEPHAN et al, 2010 Enxertos aplicados no defeito são capazes de aumentar a reparação óssea local (GRAZIANI et al, 2004, ALEXANDER, 1987 Diferentes tipos de enxertos são empregados para induzir a cicatrização de defeitos ósseos associados a diversos procedimentos ortopédicos; contudo, este enxerto deve ser biocompátivel, poroso, capaz de ancorar as células hospedeiras e ser reabsorvível. O osso autólogo continua sendo o tipo de enxerto que fornece todas estas características, demonstrando ser superior às outras enxertias (ATHANASIOU et.…”

Section: Discussionunclassified

Estudo qualitativo e quantitativo da interação entre a proteína morfogenética rhBMP-2 e diferentes tipos de enxertos ósseos

Gonzaga¹

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Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier

Cited by 67 publications

References 15 publications

Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins

Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins

Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

Estudo qualitativo e quantitativo da interação entre a proteína morfogenética rhBMP-2 e diferentes tipos de enxertos ósseos

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