Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells

Dianov, Grigory L.; Bischoff, Claus; Sunesen, Morten; Bohr, Vilhelm A.

doi:10.1093/nar/27.5.1365

Cited by 128 publications

(107 citation statements)

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“…This is compatible with the substantial amounts of data suggesting that progeria in CS is linked to accumulated endogenous DNA damage (Andressoo et al, 2006). The observation that a defect in repair of some types of oxidative damage, such as 8-oxoG, can be observed in whole cell, nuclear and mitochondrial extracts from CS cells (Dianov et al, 1999;Stevnsner et al, 2002;Tuo et al, 2002b) suggests that the CSB protein either plays a direct role in the repair process, or that it regulates expression, activity or localization of one of the involved repair proteins. It has not yet been determined whether CSB is present in mitochondria, and it is therefore possible that CSB plays an indirect role in the repair of oxidative damage in these organelles.…”

Section: The Role Of Csb In Dna Repair -And Consequences For the Aginsupporting

confidence: 85%

“…To dissect the molecular mechanisms underlying the role of CSB in the repair of oxidative lesions, several different biochemical approaches have been used. Dianov and coworkers made the first demonstration that CSB mutant cells are defective in the incision of 8-oxoG (Dianov et al, 1999). The reduced repair of 8-oxoG is associated with a down-regulation of human 8-oxoguanine DNA glycosylase (hOGG1) gene expression and protein level in CSB mutant cells (Dianov et al, 1999;Tuo et al, 2002b).…”

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

“…Dianov and coworkers made the first demonstration that CSB mutant cells are defective in the incision of 8-oxoG (Dianov et al, 1999). The reduced repair of 8-oxoG is associated with a down-regulation of human 8-oxoguanine DNA glycosylase (hOGG1) gene expression and protein level in CSB mutant cells (Dianov et al, 1999;Tuo et al, 2002b). This deficiency is complemented by transfection of CSB mutant cells with the normal CSB gene (Dianov et al, 1999).…”

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

“…The reduced repair of 8-oxoG is associated with a down-regulation of human 8-oxoguanine DNA glycosylase (hOGG1) gene expression and protein level in CSB mutant cells (Dianov et al, 1999;Tuo et al, 2002b). This deficiency is complemented by transfection of CSB mutant cells with the normal CSB gene (Dianov et al, 1999). It was shown that CSB status does not affect the incision activities of two other DNA glycosylases, thymine glycol DNA glycosylase (hNTH) and uracil DNA glycosylase (hUDG) (Dianov et al, 1999).…”

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

“…This deficiency is complemented by transfection of CSB mutant cells with the normal CSB gene (Dianov et al, 1999). It was shown that CSB status does not affect the incision activities of two other DNA glycosylases, thymine glycol DNA glycosylase (hNTH) and uracil DNA glycosylase (hUDG) (Dianov et al, 1999). As described below, CSB mutant cells are also defective in the repair of 8-oxoA, another abundant lesion in oxidatively damaged DNA, indicating that CSB might be one of the factors important for the repair of 8-oxoA (Tuo et al, 2003;Tuo et al, 2002b).…”

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

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The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

Stevnsner

Müftüoğlu

Aamann

et al. 2008

Mechanisms of Ageing and Development

123

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Cockayne Syndrome (CS) is a rare human genetic disorder characterized by progressive multisystem degeneration and segmental premature aging. The CS complementation group B (CSB) protein is engaged in transcription coupled and global nucleotide excision repair, base excision repair and general transcription. However, the precise molecular function of the CSB protein is still unclear. In the current review we discuss the involvement of CSB in some of these processes, with focus on the role of CSB in repair of oxidative damage, as deficiencies in the repair of these lesions may be an important aspect of the premature aging phenotype of CS.

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Section: The Role Of Csb In Dna Repair -And Consequences For the Aginsupporting

confidence: 85%

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

Section: The Role Of Csb In Repair Of Oxidative Dna Damagementioning

confidence: 99%

See 3 more Smart Citations

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

Stevnsner

Müftüoğlu

Aamann

et al. 2008

Mechanisms of Ageing and Development

123

View full text Add to dashboard Cite

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The draft genome of the blood pheasant (Ithaginis cruentus): Phylogeny and high‐altitude adaptation

Zhou

Liu

Liao

et al. 2020

Ecology and Evolution

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The blood pheasant ( Ithaginis cruentus ), the only species in the genus Ithaginis , lives in an extremely inhospitable high‐altitude environment, coping with hypoxia and ultraviolet (UV) radiation. To further investigate the phylogeny of Phasianidae species based on complete genomes and understand the molecular genetic mechanisms of the high‐altitude adaptation of the blood pheasant, we de novo assembled and annotated the complete genome of the blood pheasant. The blood pheasant genome size is 1.04 Gb with scaffold N50 of 10.88 Mb. We identified 109.92 Mb (10.62%) repetitive elements, 279,037 perfect microsatellites, and 17,209 protein‐coding genes. The phylogenetic tree of Phasianidae based on whole genomes revealed three highly supported major clades with the blood pheasant included in the “erectile clade.” Comparative genomics analysis showed that many genes were positively selected in the blood pheasant, which was associated with response to hypoxia and/or UV radiation. More importantly, among these positively selected genes (PSGs) which were related to high‐altitude adaptation, sixteen PSGs had blood pheasant‐specific missense mutations. Our data and analysis lay solid foundation to the study of Phasianidae phylogeny and provided new insights into the potential adaptation mechanisms to the high altitude employed by the blood pheasant.

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Human DNA repair genes

Ronen

Glickman

2001

Environ and Mol Mutagen

142

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DNA repair systems are essential for the maintenance of genome integrity. Consequently, the disregulation of repair genes can be expected to be associated with significant, detrimental health effects, which can include an increased prevalence of birth defects, an enhancement of cancer risk, and an accelerated rate of aging. Although original insights into DNA repair and the genes responsible were largely derived from studies in bacteria and yeast, well over 125 genes directly involved in DNA repair have now been identified in humans, and their cDNA sequence established. These genes function in a diverse set of pathways that involve the recognition and removal of DNA lesions, tolerance to DNA damage, and protection from errors of incorporation made during DNA replication or DNA repair. Additional genes indirectly affect DNA repair, by regulating the cell cycle, ostensibly to provide an opportunity for repair or to direct the cell to apoptosis. For about 70 of the DNA repair genes listed in Table I, both the genomic DNA sequence and the cDNA sequence and chromosomal location have been elucidated. In 45 cases single-nucleotide polymorphisms have been identified and, in some cases, genetic variants have been associated with specific disorders. With the accelerating rate of gene discovery, the number of identified DNA repair genes and sequence variants is quickly rising. This report tabulates the current status of what is known about these genes. The report is limited to genes whose function is directly related to DNA repair.

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Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells

Cited by 128 publications

References 0 publications

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

The draft genome of the blood pheasant (Ithaginis cruentus): Phylogeny and high‐altitude adaptation

Human DNA repair genes

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