REPAIR-EDS: Rehabilitation Enhanced by Partial Arterial Inflow Restriction (REPAIR) in Eheler-Danlos Syndrome (EDS) Patients

Abstract

The purpose of the current study was to test the effectiveness of combining blood flow restriction with standard physical therapy (PT BFR) exercises when compared to physical therapy exercises alone in a population of individuals living with Ehlers-Danlos Syndrome (EDS). EDS encompasses a complex spectrum of heritable connective tissue disorders characterized by genetic mutations affecting collagen synthesis and processing [1]. These mutations are inherited in varying patterns including autosomal dominant, recessive, and de novo mutations and lead to joint hypermobility, dermal dysplasia, and tissue fragility among other symptoms [2,3]. The most recent EDS classifications comprise at least 14 subtypes [4], each presenting unique clinical features and severity levels, affecting an estimated prevalence of 1 in 600 to 1 in 900 individuals depending on subtype [4-6]. Depending on the subtype, the syndrome can significantly impact functional capacity, quality of life, and longevity due to chronic pain, neuromusculoskeletal deficits, and other associated complications [7-12].Historically, traditional therapeutic approaches for EDS, which include pain management, surgery, and rehabilitation aimed at correcting deficits and improving strength and joint stability, often fall short of achieving long-term efficacy [13]. This inadequacy necessitates exploration of innovative interventions capable of addressing the underlying muscle weakness and functional impairments characteristic of the syndrome.