Repair and DNA Polymerase Bypass of Clickable Pyrimidine Nucleotides
Anton V. Endutkin,
Anna V. Yudkina,
Timofey D. Zharkov
et al.
Abstract:Clickable nucleosides, most often 5-ethynyl-2′-deoxyuridine (EtU), are widely used in studies of DNA replication in living cells and in DNA functionalization for bionanotechology applications. Although clickable dNTPs are easily incorporated by DNA polymerases into the growing chain, afterwards they might become targets for DNA repair systems or interfere with faithful nucleotide insertion. Little is known about the possibility and mechanisms of these post-synthetic events. Here, we investigated the repair and… Show more
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