Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis

Minuk, Gerald Y.; Rascanin, N.; Paul, R.; Lee, P.W.K.; Buchan, Kevin; Kelly, James K.

doi:10.1016/s0168-8278(87)80054-5

Cited by 56 publications

(25 citation statements)

References 13 publications

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“…Some studies have demonstrated a correlation between the presence of anti-reovirus antibodies and biliary atresia, while others have not (16)(17)(18)(19)(20)(21)(22)(23). Our findings may explain the discordance between anti-reovirus seropositivity and biliary atresia.…”

Section: Figurementioning

confidence: 50%

Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease

Barton¹,

Youree²,

Ebert³

et al. 2003

J. Clin. Invest.

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Infection of neonatal mice with some reovirus strains produces a disease similar to infantile biliary atresia, but previous attempts to correlate reovirus infection with this disease have yielded conflicting results. We used isogenic reovirus strains T3SA– and T3SA+, which differ solely in the capacity to bind sialic acid as a coreceptor, to define the role of sialic acid in reovirus encephalitis and biliary tract infection in mice. Growth in the intestine was equivalent for both strains following peroral inoculation. However, T3SA+ spread more rapidly from the intestine to distant sites and replicated to higher titers in spleen, liver, and brain. Strikingly, mice infected with T3SA+ but not T3SA– developed steatorrhea and bilirubinemia. Liver tissue from mice infected with T3SA+ demonstrated intense inflammation focused at intrahepatic bile ducts, pathology analogous to that found in biliary atresia in humans, and high levels of T3SA+ antigen in bile duct epithelial cells. T3SA+ bound 100-fold more efficiently than T3SA– to human cholangiocarcinoma cells. These observations suggest that the carbohydrate-binding specificity of a virus can dramatically alter disease in the host and highlight the need for epidemiologic studies focusing on infection by sialic acid–binding reovirus strains as a possible contributor to the pathogenesis of neonatal biliary atresia

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Section: Figurementioning

confidence: 50%

Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease

Barton¹,

Youree²,

Ebert³

et al. 2003

J. Clin. Invest.

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“…This, combined with the fact that reovirus possesses a highly stable unenveloped icosahedral capsid, explains why as many as 50% of adults aged 20-30 years have been exposed to reovirus over the course of their lives and thus carry antibodies against the virus (9). Seropositivity has been documented to be as high as 70-100% of subjects in some studies (10,11), despite the fact that most reovirus infections go unnoticed. In 1963, volunteers from a correctional institution demonstrated the nonpathogenic nature of reovirus; upon intranasal inoculation by serotypes 1, 2, or 3, only nine of 27 subjects developed symptoms (3).…”

Section: Introductionmentioning

confidence: 99%

Reovirus as a novel oncolytic agent

Norman

Lee²

2000

J. Clin. Invest.

110

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“…However, of the two viruses most often associated with cholestatic liver disease; HCV and CMV, serology for both were negative and CMV infections of the liver tend not to persist beyond 6 months in immune competent hosts [9]. Nonetheless, other viral pathogens such as betaretroviruses and Reovirus serotype 3 which have been implicated in the pathogenesis of human cholestatic disorders should be considered and excluded in future studies [10,11]. …”

Section: Discussionmentioning

confidence: 99%

Adult idiopathic cholestasis: a condition more common in the Canadian Inuit?

Minuk

Pollock

Uhanova

2017

International Journal of Circumpolar Health

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Despite extensive investigations, some patients have no identifiable cause for their cholestatic liver enzyme abnormalities. The aim of this study was to document the clinical, laboratory, radiologic and histologic features of adult patients with idiopathic cholestasis (AIC). A computerised database of referred patients to a tertiary care hospital outpatient department for assessment of hepatobiliary disorders between 2005 and 2015 was employed to identify and describe features associated with AIC. Of 6,560 patient referrals, sufficient documentation to warrant a diagnosis of AIC was present in 17 (0.26%) cases. Of the 17, a disproportionate number were Canadian Inuit (7/60, 12% Inuit referrals vs. 10/6,500, 0.16% non-Inuit referrals, p<0.0001). The median age of the 17 subjects was 57 years and nine (53%) were female. Clinical and/or laboratory evidence of autoimmune disorders was present in six (35%) cases. Clinical features of hepatic decompensation, radiologic findings in keeping with cirrhosis and histologic confirmation of cirrhosis were present in 47%, 31% and 42% of individuals, respectively. There were no significant improvements in cholestatic liver enzymes and function tests in those treated with ursodiol and/or immunomodulants (n=7) compared to those left untreated (n=10). In conclusion, AIC is a rare condition diagnosed by exclusion. It appears to be more common in the Canadian Inuit population and those with autoimmune disorders. Advanced liver disease is a frequent finding at presentation. Intervention with ursodiol and/or immunomodulants does not appear to be of therapeutic value.

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Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis

Cited by 56 publications

References 13 publications

Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease

Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease

Reovirus as a novel oncolytic agent

Adult idiopathic cholestasis: a condition more common in the Canadian Inuit?

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