Reoperation in the Postoperative Period of Lung Transplantation

González, D.; Paradela, Marina; Parente, Isaura; Torre, Mario; Fernández, Ramiro; Delgado, María Isabel; García, Jorge A.; Fieira, Eva; Pato, O.; Borro, J.M.

doi:10.1016/j.transproceed.2009.06.014

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…25,26 Results from previous studies have shown both, the higher rates of reoperation and lower survival rates at 1 year following the procedure among lung transplant recipients who developed by SSI, as observed in this study. 27,28 Furthermore, the survival curve for the recipients diagnosed with deep incisional SSI or organ/space SSI in the first year after lung transplant showed a decline, reflecting a shorter survival time of these recipients after lung transplant. A previous study revealed that recipients with SSI had an increased risk of death at 6 months and 1 year after transplant.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Cohort Study of Risk Factors for Surgical Site Infection Following Lung Transplant

et al. 2020

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Background: Surgical site infections (SSIs) are among the leading health care–associated infections as well as a major problem in the postoperative period of lung transplant recipients. Little is known about the risk factors in this specific population. The objective of this study was to identify the incidence, risk factors, and outcomes of SSI following lung transplant. Methods: Digital medical records of adult recipients subjected to lung transplant from July 2011 and June 2016 in a large Brazilian referral teaching public center were analyzed in this retrospective cohort follow-up. Results: Among the 121 recipients analyzed, 19 (15.7%) had SSI; of these, 11 (57.8%) had superficial incisional infections, 1 (5.2%) had a deep incisional infection, and 7 (36.8%) had organ/space infection. Recipient-related risk factors for SSI were high body mass index ( P = .041), prolonged surgery time ( P = .043), and prolonged duration of chest drain placement ( P = .009). At the multiple logistic regression was found that each hour elapsed in the surgical time increased the odds of SSI by around 2 times (odds ratio 2.34; 95% CI, 1.46-4.53; P = .002). Donor-related risk factors included smoking status ( P = .05) and positive bronchoalveolar lavage ( P < .001). Having an SSI was associated with an increased length of stay in intensive care units ( P = .003), reoperation ( P = .014), and a higher 1-year mortality rate ( P = .02). Conclusions: The identified incidence rate was higher to that observed in the previous studies. The risk factors duration of chest tube placement and donor smoking status are different from those reported in the scientific literature.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Cohort Study of Risk Factors for Surgical Site Infection Following Lung Transplant

et al. 2020

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“…The prevalence of reoperation post lung transplant was 7%, similar to previous studies. 20,21 It is possible that among patients who underwent a second surgery, the development of delayed postoperative leukocytosis represents an adequate response to the stress of a repeated operation, rather than a negative prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

The Etiology and Prognosis of Delayed Postoperative Leukocytosis in Lung Transplant Recipients

et al. 2020

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Background: Leukocytosis (white blood cell count >12 000/µL) in the delayed postoperative period (4-7 days) after lung transplantation is due to diverse etiologies. We aimed to describe the etiologies of delayed postoperative leukocytosis in lung transplant recipients and to evaluate the association of leukocytosis causes with short-term survival. Methods: A retrospective chart review of 274 lung transplantations performed in our institution during 2006 to 2013. Results: Delayed postoperative leukocytosis was seen in 159 (58.0%) of lung transplant recipients. In 57 (35.8%) of them, the etiology of the leukocytosis was not identified. The etiologies of leukocytosis that were identified were infection (n = 39), second surgery, acute rejection (n = 12), primary graft dysfunction (n = 3), multiple etiologies (n = 17), and other causes (n = 10). On multivariate analysis, delayed postoperative leukocytosis was one of the variables that most significantly associated with decreased survival in the entire sample (hazard ratio [HR] = 1.52, 95% confidence interval [CI]: 1.01-2.29, P = .040). On additional analysis for mortality assessing each leukocytosis subgroup, the data were acute graft rejection (HR = 8.21, 95% CI: 4.09-16.49, P < .001), second surgery (HR = 2.05, 95% CI: 1.08-3.90, P = .020), primary graft dysfunction (HR = 2.72, 95% CI: 0.65-11.33, P = .169), other causes (HR = 1.30, 95% CI: 0.47-3.62, P = .620), and unknown etiology (HR = 0.94, 95% CI: 0.54-1.62, P = .800). Conclusions: Delayed post-lung transplant leukocytosis is a poor prognostic sign, especially when attributed to acute graft rejection, infection, and multiple etiologies. In the absence of an identifiable etiology, it can be attributed to postoperative reactive stress, is not associated with increased mortality, and likely does not warrant further diagnostic investigation.

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Separate Effect of Perioperative Recombinant Human Factor VIIa Administration and Packed Red Blood Cell Transfusions on Midterm Survival in Lung Transplantation Recipients

Huddleston

Jackson

Kane

et al. 2020

Journal of Cardiothoracic and Vascular Anesthesia

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Reoperation in the Postoperative Period of Lung Transplantation

Cited by 3 publications

References 6 publications

A Retrospective Cohort Study of Risk Factors for Surgical Site Infection Following Lung Transplant

A Retrospective Cohort Study of Risk Factors for Surgical Site Infection Following Lung Transplant

The Etiology and Prognosis of Delayed Postoperative Leukocytosis in Lung Transplant Recipients

Separate Effect of Perioperative Recombinant Human Factor VIIa Administration and Packed Red Blood Cell Transfusions on Midterm Survival in Lung Transplantation Recipients

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