Renovascular Hypertension Due to Neurofibromatosis

Mp, Fleming; We, Miller

doi:10.2214/ajr.113.3.452

Cited by 16 publications

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“…The cardiovascular manifestations of neurofibromatosis may include hypertension due to renal artery stenosis, coarctation of the aorta, and less frequently pheochromocytoma [4,6,8]. Pheochromocytoma is described primarily in adults and has a projected incidence of 1% [5].…”

Section: Discussionmentioning

confidence: 99%

Neurofibromatosis with Cardiac Involvement

et al. 1997

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Section: Discussionmentioning

confidence: 99%

Neurofibromatosis with Cardiac Involvement

et al. 1997

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“…In 1971, Fleming and Miller 5 reported only the 17th case of renovascular hypertension due to neurofibromatosis. Radioisotope renograms and renal schintigram suggested stenosis of the left renal artery in this case of a seven-year-old boy.…”

Section: Diagnosismentioning

confidence: 99%

Renovascular Hypertension

Takekawa¹,

Sai²,

Kawakura³

et al. 2016

J Rad Idn

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“…[1][2][3][4][5][6][7][8][9] The disease may involve the vascular system10-13 and cause coarctation of the aorta, stenotic or aneurysmal changes in arteries, and may-if renal arteries are involved-result in hypertension. [14][15][16][17][18][19] The purpose of the present communication is to emphasize the importance of angiography in generalized neurofibromatosis with hypertension and for determination of the source of the gastrointestinal bleeding. We intend, however, also to show that in a patient with generalized neurofibromatosis vascular or intestinal lesions detected at angiography, and resembling those described in generalized neurofibromatosis may really be of different etiology.…”

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Angiographic Findings in Two Cases of Generalized Neurofibromatosis

1973

Vascular Surgery

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Neurofibromatosis is a congenital and hereditary disease. It may involve any organ of neuroectodermal or mesodermal origin. Manifestations of the skin, subcutaneous tissue and bones are common. Neurofibromatosis of the gastrointestinal tract may result in complications such as obstruction, bleeding or malignancy.1-9 The disease may involve the vascular system10-13 and cause coarctation of the aorta, stenotic or aneurysmal changes in arteries, and may-if renal arteries are involved-result in hypertension. 14-19The purpose of the present communication is to emphasize the importance of angiography in generalized neurofibromatosis with hypertension and for determination of the source of the gastrointestinal bleeding. We intend, however, also to show that in a patient with generalized neurofibromatosis vascular or intestinal lesions detected at angiography, and resembling those described in generalized neurofibromatosis may really be of different etiology. CASE REPORTS CASE 1. 23 year old male with generalized neurofibromatosis (caf6 au lait spots, previous right leg amputation for &dquo;foot anomaly&dquo;, bone lesions of spine and ribs). Blood pressure between 160-170 mm Hg systolic and 106--130 diastolic. An aortogram at another hospital had demonstrated a superior mesenteric artery aneurysm, and multiple renal artery aneurysms. The patient was admitted to the University of Alabama Hospital for further hypertensive work-up. Three urinary VMA determinations and an intravenous pyelogram were normal. The renal vein renin values were elevated, 725 nonnog/1 on the left and 555 nonnog/1 on the right. Bilateral selective renal angiograms demonstrated six saccular aneurysms of the right renal artery (Fig. 1). The largest of the aneurysms measured 2 cm. A single small aneurysm originated from the left main renal artery base (Fig. 2). The bilateral renal artery disease was considered not correctable by surgery and the patient was discharged with medical antihypertensive treatment. CASE 2. 41 year old female with generalized neurofibromatosis (caf6 au lait spots, cutaneous neurofibromata, bone lesions of skull, spine and left femur) was admitted to the University

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Renovascular Hypertension Due to Neurofibromatosis

Cited by 16 publications

References 0 publications

Neurofibromatosis with Cardiac Involvement

Neurofibromatosis with Cardiac Involvement

Renovascular Hypertension

Angiographic Findings in Two Cases of Generalized Neurofibromatosis

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