Renoprotective Effect of Co-Enzyme Q10 and N-Acetylcysteine on Streptozotocin-Induced Diabetic Nephropathy in Rats

Mahajan, Manoj; D, Upasani Chandrashekhar; B, Upaganlawar Aman; S, Gulecha Vishal

doi:10.23937/2377-3634/1410123

Cited by 11 publications

(20 citation statements)

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“…14,26,27 Therefore, this study was focused to evaluate the antidiabetic activity of ethanol extract of longjack leaf in streptozotocin-nicotinamide induced rats. According to Mahajan et al (2020) 10 ; Szkudelski (2012) 40 the streptozotocin administration was reported to damage pancreatic β cells by forming free radicals, similarly nature impairments occur in diabetes. Moreover, the decline of blood glucose levels made malondialdehyde levels also decreased.…”

Section: Resultsmentioning

confidence: 99%

“…7 Previous studies revealed that one of the triggered factors in hyperglycaemia is the upsurge of free radical production or reactive oxygen species (ROS); the intensification of ROS activity can injure various tissues in the body. 6,[8][9][10] Moreover, the hyperglycaemia condition also promotes the increase of ROS production in all tissues through the process of glucose auto-oxidation and protein glycosylation. Meanwhile, in the oxidative stress condition, the levels of antioxidant enzymes extensively affect the susceptibility of various tissues associated to complications in patients with diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, in the oxidative stress condition, the levels of antioxidant enzymes extensively affect the susceptibility of various tissues associated to complications in patients with diabetes. 6,[8][9][10] The main target of ROS is lipid, and one of the decomposition products from lipid oxidation is malondialdehyde, which is formed from prostaglandin biosynthesis, such as endoperoxides from polyunsaturated fatty acids. 6,9,11 Previously, it has been reported that malondialdehyde is systematically linked to metabolic parameters in patients with diabetes type 1 and 2, and is stated that the patients with diabetes in severe metabolic control will show the high plasma levels of malondialdehyde and are significantly different with diabetic patients in better metabolic control.…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic Activity of the Leaf Extract of Eurycoma Longifolia Jack. in Streptozotocin-Nicotinamide Induced Diabetic Model

Panjaitan¹,

Astuti²

2021

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Background: One of the medication attempts in diabetes mellitus is by utilising plants that are potent as an antioxidant. Eurycoma longifolia Jack. known as "Longjack" in English, is a medicinal plant and reportedly effective as an antioxidant. Objectives: This study was aimed to examine the antidiabetic effectiveness of ethanol extract of longjack leaf in diabetes mellitus rats. Methods: This study used the total of 24 male white rats which were grouped into four. The normal and the negative control groups were administrated with CMC-Na 0.5% dose 2 ml/200 g body weight; one group was administrated with ethanol extract of longjack leaf dose 176.4 mg/200 g body weight; and the positive control group was administrated with glibenclamide dose 0.09 mg/200 g body weight. Before the extract administration, all of the experimental animals were prior induced into diabetic condition with streptozotocin-nicotinamide. Results: The levels of blood glucose and malondialdehyde in rats after the 14-day extract treatments were 78.73 mg/dl and 1.13 nmol/ml, respectively in the normal control group; 285.84 mg/dl and 10.03 nmol/ml were in the negative control group; 156.77 mg/dl and 3.86 nmol/ml in the group with the administration of ethanol extract of longjack leaf; and 148.63 mg/dl dan 3.64 nmol/ml in the group of glibenclamide administration (p<0.05). The reduction of blood glucose and malondialdehyde levels in the groups of ethanol extract administration of longjack leaf dose 176.4 mg/200 g body weight was similar to the glibenclamide administration dose 0.09 mg/200 g body weight. Conclusion: The ethanol extract of longjack leaf was effective as an antidiabetic.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antidiabetic Activity of the Leaf Extract of Eurycoma Longifolia Jack. in Streptozotocin-Nicotinamide Induced Diabetic Model

Panjaitan¹,

Astuti²

2021

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“…This can be due to deteriorated excretory and regulatory renal function to maintain constant homeostasis of these parameters. 28,31 As treatment with O. indicum fruit extract significantly normalizes the levels of altered serum and urine parameters. Nephropathy rats show the presence of glucose in the urine.…”

Section: Discussionmentioning

confidence: 97%

“…The present results are in line with previously presented literature. 20,31 An increase in 24 hr. urine volume and in the weight of the kidney (hypertrophy index) in proportion to body weight was observed in STZ-induced diabetes in rats.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effects of Oroxylum Indicum fruit extract in diabetes induced nephropathy in rats

Joshi¹,

Mahajan²,

Upaganlawar³

et al. 2021

IJPP

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Background: Nephropathy is one of the important microvascular complications of diabetes. In the present study, Oroxylum indicum fruit extract was screened for its probable nephroprotective effects in streptozotocin-induced diabetic rats. Materials and Methods: Male albino rats of Wistar strain (200-250gm) were used in the study. Rats were divided into various groups each containing six rats. Nephropathy was induced by the injection of freshly prepared streptozotocin (60 mg/kg, i.p.). After confirmation of diabetic nephropathy, rats were treated with Oroxylum indicum fruit extract at three different doses i.e. 100, 200, 400 mg/kg/orally for four weeks. Nephropathy was assessed by evaluating biochemical parameters such as blood glucose, total protein, albumin, urea, uric acid, creatinine, and total bilirubin from serum and urine. The markers of oxidative stress such as lipid peroxidation, reduced glutathione, and tissue nitrite level were estimated from kidney homogenates. Histopathology of the kidney sample was also carried out. Result and Conclusion: Nephropathy-induced rats showed a significant alteration in biochemical and markers of oxidative stress. Treatment with Oroxylum indicum fruit extract significantly attenuated the altered parameters towards normal. The fruit extract showed dose-dependent effects, where 400 mg/kg showed good nephroprotective effects compared to 100 and 200 mg/kg. This dose-dependent activity of the fruit might be due to the presence of polar flavonoid and tannin which has been reported as strong free radical scavengers. Key Messages: Oroxylum indicum fruit has nutritional value and it is used for various medicinal purposes. This study gives an idea about the use of Oroxylum indicum fruit in diabetic nephropathy.

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The NADH-ubiquinone reductase and succinate dehydrogenase activity in the rat kidney mitochondria under the conditions of different protein and sucrose content in the diet

Voloshchuk¹,

Ursatyy²,

Kopylchuk³

2022

Ukr. Biochem. J.

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NaDh-ubiquinone reductase (Ec 7.1.1.2) and succinate dehydrogenase (Ec 1.3.5.1) activity, the levels of total ubiquinone and its redox forms, and the degree of oxidative modification of mitochondrial proteins in the rat kidney were investigated. It was found that when consuming a low-protein diet there is a decrease in NaDh-ubiquinone reductase and succinate dehydrogenase activity by 1.4-1.7 times, a 20% decrease in total ubiquinone and a quantitative redistribution of its oxidized and reduced form with a predominance of oxidized form. Under the studied conditions, there is no accumulation of carbonyl derivatives, but the level of free Sh-groups is significantly reduced compared with control. at the same time, in animals consuming a high-sucrose diet there is an increase in NaDh-ubiquinone reductase and succinate dehydrogenase activity by 1.5-2 times and maintenance of the total ubiquinone at the control level against the background of redistribution of its redox forms, namely a decrease in reduced ubiquinone and an increase in oxidized ubiquinone on average by 1.5 times. In addition, there is an intensification of the reactions of free radical damage of mitochondrial proteins in kidney cells, as evidenced by an increase in the level of carbonyl derivatives and a significant decrease in the level of free protein Sh-groups by approximately 1.4-1.5 times. the most pronounced changes in the studied indicators are found in animals that consumed a low-protein/ high-sucrose diet. In particular, an excessive consumption of sucrose on the background of protein deficiency is accompanied by a reduction of NaDh-ubiquinone reductase and succinate dehydrogenase activity by 1.7-2 times, a decrease in total ubiquinone level by approximately 1.4 times, and a two-fold decrease in reduced ubiquinone against the background of intensification of the free radical oxidation of mitochondrial proteins, which can be considered as a prerequisite for the impairment of the renal function under the conditions of carbohydrate-protein imbalance. K e y w o r d s: nutrients, kidney, NaDh-Ubiquinone reductase, succinate dehydrogenase, ubiquinone, carbonyl derivatives, protein Sh-group.

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Renoprotective Effect of Co-Enzyme Q10 and N-Acetylcysteine on Streptozotocin-Induced Diabetic Nephropathy in Rats

Cited by 11 publications

References 0 publications

Antidiabetic Activity of the Leaf Extract of Eurycoma Longifolia Jack. in Streptozotocin-Nicotinamide Induced Diabetic Model

Antidiabetic Activity of the Leaf Extract of Eurycoma Longifolia Jack. in Streptozotocin-Nicotinamide Induced Diabetic Model

Nephroprotective effects of Oroxylum Indicum fruit extract in diabetes induced nephropathy in rats

The NADH-ubiquinone reductase and succinate dehydrogenase activity in the rat kidney mitochondria under the conditions of different protein and sucrose content in the diet

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