Renoprotective and therapeutic effects of newly water, ethanol, and butanol ginseng fractions in hypertensive and chronic kidney disease with L-NAME

Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice

“…starting earlier) to avoid potential L-NAME-induced systemic toxicities, i.e. hypertension [ 48 ], hepatic and intestinal toxicity [ 49 ] or nephrotoxicity [ 50 ]. Taken together, these results (see also Table 2 ) indicate that NO, and consequently mixed nitrogen- and oxygen-derived reactive species, cytokines and neuroinflammation are involved in the mechanism that leads to the damage of MNs.…”

The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

“…P significantly increased GSH levels and decreased lipid peroxidation, according to Wahdan et al [ 85 ]. Interestingly, the antioxidant and anti-cancer activities of the AP extract could be attributed to the bioactive compounds which were identified via GC-MASS spectra and investigated previously for their antioxidant and anticancer activities, such as Methyl α-D-glucopyranoside [ 46 , 47 ], 5,8,11,14-Eicosatetraynoic acid TMS derivative [ 48 ], Dasycarpidan-1-methanol, acetate [ 49 ], Traumatic acid, (E)-, 2TMS derivative [ 50 ], Panaxydol, TMS [ 51 ], 2-Oleoylglycerol, 2TMS derivative [ 52 ], alpha-D-Mannopyranoside, methyl 2,3,5,6-tetrakis-O-(trimethylsilyl) [ 53 ], Uridine, 3TMS derivative [ 54 ], Methyl alpha-D-galactopyranoside [ 55 ], Methyl à-D-glucofuranoside, 4TMS derivative [ 56 ], D-(-)-Tagatofuranose,pentakis (trimethylsilyl) ether [ 57 ], D-(-)-Fructofuranose, pentakis(trimethylsilyl) ether [ 58 ], D-Psicofuranose, pentakis(trimethylsilyl) ether [ 58 ], 1,5-Anhydrohexitol, 4TMS derivative [ 59 ], α- DL- Arabinopyranose, 1,2,3,4- tetrakis-O-(trimethylsilyl) [ 60 ], Mannoonic acid, 2,3,5,6-tetrakis-O-(trimethylsilyl)-, lactone [ 61 ], Dulcitol, 6TMS derivative [ 62 ], D-Sorbitol, 6TMS derivative [ 63 ], Butanal, 2,3,4-tris[(trimethylsilyl)oxy]-3-[[(trimethylsilyl)oxy]methyl]-[ 64 ], L-Fucitol, and 5TMS derivative [ 65 ].…”

Repercussions of pathway inhibition response of Panaxginseng fractions ameliorate cardiac dysfunction in hypertensive model rats

“…All three fractions were concentrated and dried under reduced pressure in a rotary evaporator and then stored at 4°C. Chemical analyses were conducted by gas chromatography/mass spectroscopy (GC/MS) as described (Ragab et al 2021).…”

“…Amines, amides, furans, and ketones were all present at trace amounts in all three fractions (less than 1%). Ginseng has a high carbohydrate content in general, and carbohydrates accounted for 79.00% of compounds in the GEF, 74.45% of those in the GWF, and 45.22% of those in the GBF ( Ragab et al 2021).…”