Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats

Borgohain, Manash P.; Chowdhury, Liakat; Ahmed, Sahabuddin; Bolshette, Nityanand; Devasani, Karan; Das, T.J.; Mohapatra, Anjali; Lahkar, Mangala

doi:10.1016/j.jep.2017.01.035

Cited by 29 publications

(17 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of herbal medicine is increasingly being recognized and explored as suitable alternative for the treatment of diabetes due to their perceived efficacy and limited side effects . A large number of the world's diabetic population rely on medicinal plants or its preparation for their treatment, thus show casing the arsenal of valuable therapeutic potentials embedded in these plants . Despite the numerous pharmacological studies on L. chinense (mostly the root back and the fruit), the leaves of the plant have received little attention.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats

Olatunji

Chen

Zhou

2017

Chemistry & Biodiversity

View full text Add to dashboard Cite

Lycium chinenseMill., popularly known as boxthorn, is a plant that is traditionally used for treating night sweat, cough, inflammation and diabetes mellitus. However, the leaves have received little or no attention despite their potentials as a potent therapeutic agent. This study was aimed at investigating the hypoglycemic and hypolipidemic effects of the polyphenols-rich ethyl acetate fraction from the leaves of Lycium chinenseMill. on streptozotocin-nicotinamide induced diabetic rats. The ethyl acetate fraction (LFE) was selected and orally gavaged at 100, 200, and 400 mg/kg dose to streptozotocin (STZ)-nicotinamide induced diabetic rats. The rats' body weight, fasting blood glucose (FBG), lipid profile and oxidative stress markers were evaluated after the treatment period. Treatment with LFE resulted in a significant decrease in the FBG level, altered lipid profiles, and reduced the activities of the enzymes alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT) in the treated diabetic rats. Furthermore, LFE significantly elevated the antioxidant status (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities) and reducing malondialdehyde (MDA) levels in the treated rats. The present study has revealed that L. chinenseMill. possess anti-hyperglycemic and anti-hyperlipidemic properties which is mediated through modulation of oxidative stress and polyphenolics might be responsible for the action.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats

Olatunji

Chen

Zhou

2017

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…integrin-linked kinase, EMT, MMP-9/TIMP-1 ratio [127] ( 10 Journal of Diabetes Research 12 Journal of Diabetes Research ↓: decreased/prevented the increase (of activity (for enzymes)/level (for biochemical parameters))/inhibited/inactivated/blocked/suppressed/downregulated (about pathways, enzymes, receptors, cytokines, etc. ); ↑: increased/prevented the decrease (of activity (for enzymes)/level (for biochemical parameters))/stimulated/activated/upregulated; →: [172], Chlorella pyrenoidosa [173], Cladophora glomerata [34], Coccinia indica [111], coconut water [61], Cordyceps militaris [114], Cornus officinalis [47], curcumin [79], dihydroquercetin [48], Dioscorea bulbifera [96], diosgenin [62], ellagic acid [37], emodin § [94], Flammulina velutipes [53], Fragaria × ananassa [89], Huangqi decoction [36], Hypericum perforatum [31], Paederia foetida [78], Paeonia emodi [63], palm oil and rice bran oil [50], Panax notoginseng [35], Panax quinquefolium [82], Panax quinquefolium [83], Physalis angulata [64], Pleurotus eryngii polysaccharides [57], Prunella vulgaris [84], Punica granatum [32], quercetin [49], Ramulus mori [77], Rheum ribes [175], secoisolariciresinol diglucoside [88], Spirogyra neglecta [176], Tangke decoction [116], Terminalia chebula [33] Insulin resistance…”

Section: In Vitro Studies-potentially Nephroprotectivementioning

confidence: 99%

“…Berberine [117], Zea mays anthocyanins [70], 16 Journal of Diabetes Research Abelmoschus manihot [104], berberine [85], crocin [73], curcumin [79], curcumin analogue (B06) [66], dihydroquercetin [48], d-pinitol [2], ellagic acid [37], Hypericum perforatum [31], isorhamnetin [87], moringa isothiocyanate [42], Morus alba [77], Paederia foetida [78], Paeonia lactiflora [120], celastrol [170], resveratrol [144] Tumor necrosis factor-α (TNF-α)…”

Section: Tissue Inhibitor Of Mmps-(timp-) 2 and Mmp-2/timp-2 Ratiomentioning

confidence: 99%

“…Abelmoschus manihot [104], Abelmoschus manihot [156], Allium sativum [28], berberine [85], crocin [73], curcumin [79], curcumin analogue (B06) [66], d-pinitol [2], ellagic acid [37], emodin [94], Fragaria × ananassa [89], Hypericum perforatum [31], isorhamnetin [87], Morus alba [77], Paederia foetida [78], Paeonia lactiflora [120], secoisolariciresinol diglucoside [88], Shen-Yan-Fang-Shuai Formula [80], silymarin [65] (human), astragaloside IV [103], celastrol [170], resveratrol [144], Abelmoschus manihot [143], ferulic acid [145] Chemokines Monocyte chemoattractant/chemotactic protein-1 (MCP-1)…”

Section: Tissue Inhibitor Of Mmps-(timp-) 2 and Mmp-2/timp-2 Ratiomentioning

confidence: 99%

“…Downregulating the activity of NF-κB dependent pathways is one of the most explored anti-inflammatory renoprotective mechanism of the herbal products. In most studies, NF- κ B inactivation is accompanied by lower levels of proinflammatory factors, including various combinations of proinflammatory cytokines: IL-1 (and IL-1 receptor), IL-6, interferon- γ , and TNF- α ( Morus alba [ 77 ]), TNF- α , IL-1 β , and IL-6 ( Paederia foetida [ 78 ], d-pinitol from soybean [ 2 ]).…”

Section: Herbal Nephroprotectionmentioning

confidence: 99%

See 2 more Smart Citations

Mechanisms of Herbal Nephroprotection in diabetes mellitus

Dragoș

Manea

Timofte

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a leading cause of kidney morbidity. Despite the multilayered complexity of the mechanisms involved in the pathogenesis of DN, the conventional treatment is limited to just a few drug classes fraught with the risk of adverse events, including the progression of renal dysfunction. Phytoceuticals offer a promising alternative as they act on the many-sidedness of DN pathophysiology, multitargeting its intricacies. This paper offers a review of the mechanisms underlying the protective action of these phytoagents, including boosting the antioxidant capabilities, suppression of inflammation, averting the proliferative and sclerosing/fibrosing events. The pathogenesis of DN is viewed as a continuum going from the original offense, high glucose, through the noxious products it generates (advanced glycation end-products, products of oxidative and nitrosative stress) and the signaling chains consequently brought into action, to the harmful mediators of inflammation, sclerosis, and proliferation that eventually lead to DN, despite the countervailing attempts of the protective mechanisms. Special attention was given to the various pathways involved, pointing out the ability of the phytoagents to hinder the deleterious ones (especially those leading to, driven by, or associated with TGF-β activation, SREBP, Smad, MAPK, PKC, NF-κB, NLRP3 inflammasome, and caspase), to promote the protective ones (PPAR-α, PPAR-γ, EP4/Gs/AC/cAMP, Nrf2, AMPK, and SIRT1), and to favorably modulate those with potentially dual effect (PI3K/Akt). Many phytomedicines have emerged as potentially useful out of in vitro and in vivo studies, but the scarcity of human trials seriously undermines their usage in the current clinical practice—an issue that stringently needs to be addressed.

show abstract

Nephro‐protective effects of alpha‐lipoic acid in type I diabetes

Kushwaha,

Mandal,

Khurana

et al. 2024

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Type 1 diabetes (T1D) is an insulin‐dependent autoimmune condition. Short chain fatty acids (SCFAs) are volatile fatty acids with 1–6 carbon atoms that influence glucose storage in the body and can reduce appetite, potentially decreasing T1D risk. Alpha‐lipoic acid (α‐LA), a type of SCFA, has previously been used to treat diabetic neuropathy and inflammation due to its antioxidant properties. This study aims to assess α‐LA's protective effects against T1D and associated kidney damage in rats induced with streptozotocin. Diabetic rats were treated with α‐LA orally for 15 days, resulting in improved blood glucose (56% decrease) and kidney function markers like blood urea nitrogen, creatinine and uric acid. α‐LA also showed significant antioxidant effects by decreasing LPO as well as improving activities of antioxidant enzymes like superoxide dismutase, catalase and glutathione‐S transferase and alleviated kidney damage caused by diabetes. Docking experiments suggest that α‐LA may regulate diabetes‐related changes at the epigenetic level through interactions with the SIRT1 protein, indicating its potential as a target for future antidiabetic drug development.

show abstract

Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats

Cited by 29 publications

References 48 publications

Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats

Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats

Mechanisms of Herbal Nephroprotection in diabetes mellitus

Nephro‐protective effects of alpha‐lipoic acid in type I diabetes

Contact Info

Product

Resources

About