Abstract:Background/Aim: Matrix metalloproteinases (MMPs) play pivotal roles in extracellular matrix turnover and are involved in chronic kidney disease. The renoprotective action of a synthetic MMP inhibitor, compound A, was investigated in chronic nephritis. Methods: Nephritis was induced by a single injection of anti-Thy1.1 antibody to unilaterally nephrectomized rats. The effects of compound A on proteinuria, blood urea nitrogen, and matrix-related gene expressions were evaluated. Collagen accumulation, as assessed… Show more
“…Interestingly, upregulation of MMPs is not limited to LN and can occur in several types of acute or chronic kidney injury, also in the absence of glomerular Ab deposition. 47 …”
“…Interestingly, upregulation of MMPs is not limited to LN and can occur in several types of acute or chronic kidney injury, also in the absence of glomerular Ab deposition. 47 …”
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