Renin-like activity in ovarian follicular fluid

Fernandez, Leonardo A.; Tarlatzis, Basil C.; Rzasa, Peter; Caride, Vicente J.; Laufer, Neri; Negro‐Vilar, A.; DeCherney, Alan H.; Naftolin, Frederick

doi:10.1016/s0015-0282(16)48740-6

Cited by 117 publications

(44 citation statements)

References 14 publications

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“…Since submission of this manuscript, Fernandez et al (32) reported the presence of renin-like activity in human ovarian follicular fluid. This observation is consistent with the view that the source of the fluctuations in prorenin during the menstrual cycle is the ovary.…”

Section: Discussionmentioning

confidence: 99%

Cyclical secretion of prorenin during the menstrual cycle: synchronization with luteinizing hormone and progesterone.

Sealey¹,

Atlas²,

Glorioso³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

103

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Plasma prorenin, a high molecular weight precursor form of renin, (renin, EC 3.4.23.15; old number, EC 3.4.99.19), was measured three times weekly in normal young women during the menstrual cycle and was related to changes in luteinizing hormone, estradiol, and progesterone. In all subjects a stable baseline level of prorenin occurred during the follicular phase. Then, simultaneously or soon after the luteinizing hormone peak, plasma prorenin consistently increased about 2-fold. Baseline prorenin ranged from 18 to 40 ng per ml per hr, and peak prorenin ranged from 35 to 65 ng per ml per hr. The maximum increase in prorenin averaged 80%. Prorenin remained elevated during the mid-luteal phase of the menstrual cycle and returned to baseline during the late-luteal phase in coordination with the decrease in progesterone. The changes in prorenin were not synchronized with changes in active renin which was significantly increased only during the mid-luteal phase. These rmdings suggest that prorenin may be involved in reproductive physiology.The renin-angiotensin system regulates blood pressure and fluid and electrolyte balance by the actions of angiotensin II (1). This octapeptide causes arteriolar vasoconstriction; it also causes stimulation of aldosterone biosynthesis (2) by increasing the conversion of cholesterol to pregnenolone in the adrenal zona glomerulosa cells (3).An inactive, high molecular weight form of renin (EC 3.4.23.15; old number EC 3.4.99.19), prorenin, found in human plasma (4) has been shown to be the biosynthetic precursor of active renin (5, 6). Unlike most hormone precursors which constitute a minor proportion of the circulating hormone pool, prorenin normally circulates in concentrations close to 10 times that of active form (4). Whereas circulating active renin appears to be exclusively of renal origin, plasma prorenin is derived from the kidney and from other tissues as well (7, 8) Circumstantial evidence suggests that prorenin may be linked to reproductive function, but no clear role has emerged. Prorenin is present in amniotic fluid (9) in concentrations two orders of magnitude higher than in normal human plasma, and it is synthesized in the chorionic cells of the placenta (10). Maternal plasma prorenin increases during pregnancy (11-15); it is increased as much as 10-fold within the first 4 weeks following conception, and it decreases rather slowly postpartum (15). This increase in pregnancy parallels the early increase in human chorionic gonadotropin (15).The early increase in prorenin following conception and the slow decrease postpartum suggested to us (15) that the increase in plasma prorenin during pregnancy might be maternal, not fetal, in origin and that prorenin might also increase during the luteal phase of the menstrual cycle in nonpregnant subjects. We, therefore, investigated changes in prorenin in young women during the menstrual cycle in relation to known changes (16) in luteinizing hormone (LH), progesterone, and estradiol.MATERIALS AND METHODS Subjects. All of the...

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Section: Discussionmentioning

confidence: 99%

Cyclical secretion of prorenin during the menstrual cycle: synchronization with luteinizing hormone and progesterone.

Sealey¹,

Atlas²,

Glorioso³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

103

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“…In this regard, the correction of abdominal ascites by a chest tube placed to drain pleural effusion has been reported recently in a patient with severe OHSS (12). Plasma levels of renin activity, active renin, prorenin, and Ang II-ir were clearly higher than those observed in patients stimulated with gonadotropins for IVF on the day of oocyte retrieval (9)(10)(11)13), suggesting peripheral stimulation of the RAS during OHSS. Active renin was measured by an immunoradiometric assay.…”

Section: Discussionmentioning

confidence: 89%

Features of the renin-angiotensin system in ascites and pleural effusion during severe ovarian hyperstimulation syndrome

Delbaere

Bergmann

Englert

1997

J Assist Reprod Genet

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“…Ovaries are able to synthesize pro-renin [14] and renin [15]. Additionally, the follicular and ascitic fluid concentration of angiotensin II are higher than the plasma concentration in women with OHSS [15], and elevation of …”

Section: Renin-angiotensin Systemmentioning

confidence: 99%

Ovarian hyperstimulation syndrome: pathophysiology and prevention

Nastri

Ferriani

Rocha

et al. 2010

J Assist Reprod Genet

190

157

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Purpose To review and discuss the pathophysiology and prevention strategies for ovarian hyperstimulation syndrome (OHSS), which is a condition that may occur in up to 20% of the high risk women submitted to assisted reproductive technology cycles. Methods The English language literature on these topics were reviewed through PubMed and discussed with emphasis on recent data. Results The role of estradiol, luteinizing hormone, human chorionic gonadotropin (hCG), inflammatory mediators, the renin-angiotensin system and vascular endothelial growth factor is discussed in the pathophysiology of OHSS. In addition we consider the prevention strategies, including coasting, administration of albumin, renin-angiotensin system blockage, dopamine agonist administration, nonsteroidal anti-inflammatory administration, GnRH antagonist protocols, reducing hCG dosage, replacement of hCG and in vitro maturation of oocytes (IVM). Conclusions Among the many prevention strategies that have been discussed, the current evidence points to the replacement of hCG by GnRH agonists in antagonist cycles and the performance of IVM procedures as the safest approaches.

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Renin-like activity in ovarian follicular fluid

Cited by 117 publications

References 14 publications

Cyclical secretion of prorenin during the menstrual cycle: synchronization with luteinizing hormone and progesterone.

Cyclical secretion of prorenin during the menstrual cycle: synchronization with luteinizing hormone and progesterone.

Features of the renin-angiotensin system in ascites and pleural effusion during severe ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome: pathophysiology and prevention

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