Renin-Angiotensin-Aldosterone System and Natriuretic Peptides as Possible Targets of Waon Therapy in Heart Failure

Fukushima, Arata; Kinugawa, Shintaro

doi:10.1253/circj.cj-17-0286

Cited by 3 publications

(2 citation statements)

References 15 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study clarified the correlation between EI and HF severity in patients with CHD. Decompensated HF generally leads to fluid retention caused by increased ventricular filling pressure and neurohormonal activation . In the present study, EI was significantly correlated with NYHA FC or log BNP level.…”

Section: Discussionsupporting

confidence: 57%

See 1 more Smart Citation

Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease

Satō

Inai

Shimizu

et al. 2018

Congenital Heart Disease

View full text Add to dashboard Cite

| INTRODUC TI ONFluid retention with dyspnea is the most often encountered cause of rehospitalization after acute heart failure (HF). Decompensated HF generally leads to fluid overload caused by elevated ventricular filling pressure or neurohormonal activation. Thus, the ability to recognize and quantify fluid retention is critical for the treatment of HF; however, optimal markers for the presence of fluid retention have yet to be identified. Brain natriuretic peptide (BNP) testing, chest radiography, cardiac ultrasonography, and blood sampling are insufficient for assessing fluid retention.Bioelectrical impedance analysis (BIA) was recently introduced in many clinical fields, such as cardiology, nephrology, hepatology, nutrition, and rehabilitation. 1-9 BIA is a safe, rapid, and noninvasive assessment method that involves the application of alternating currents to the body to achieve 8-polar tactile-electrode impedance. These impedances are obtained using differences in cell membrane permeability based on variable frequencies. AbstractObjective: The recognition of fluid retention is critical in treating heart failure (HF).Bioelectrical impedance analysis (BIA) is a well-known noninvasive method; however, data on its role in managing patients with congenital heart disease (CHD) are limited.Here, we aimed to clarify the correlation between BIA and HF severity as well as the prognostic value of BIA in adult patients with CHD.Design: This prospective single-center study included 170 patients with CHD admitted between 2013 and 2015. We evaluated BIA parameters (intra-and extracellular water, protein, and mineral levels, edema index [EI, extracellular water-to-total body water ratio]), laboratory values, and HF-related admission prevalence. Results: Patients with New York Heart Association (NYHA) functional classes III-IVhad a higher EI than those with NYHA classes I-II (mean ± SD, 0.398 ± 0.011 vs 0.384 ± 0.017, P < .001). EI was significantly correlated with brain natriuretic peptide level (r = 0.51, P < .001). During the mean follow-up period of 7.1 months, Kaplan-Meier analysis showed that a discharge EI > 0.386, the median value in the present study, was significantly associated with a future increased risk of HF-related admission (HR = 4.15, 95% CI = 1.70-11.58, P < .001). A body weight reduction during hospitalization was also related to EI reduction.Conclusions: EI determined using BIA could be a useful marker for HF severity that could predict future HF-related admissions in adult patients with CHD.

show abstract

Section: Discussionsupporting

confidence: 57%

“…Decompensated HF generally leads to fluid retention caused by increased ventricular filling pressure and neurohormonal activation. [19][20][21][22][23][24][25] In the present study, EI was significantly correlated with NYHA FC or log BNP…”

Section: Correlation Between Bia and Hf Severitysupporting

confidence: 61%

Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease

Satō

Inai

Shimizu

et al. 2018

Congenital Heart Disease

View full text Add to dashboard Cite

show abstract

Effect of Waon Therapy in Individuals With Heart Failure: A Systematic Review

Conceição

Queiroz

Neto

et al. 2018

Journal of Cardiac Failure

View full text Add to dashboard Cite

Effect of sacubitril valsartan on cardiac function and endothelial function in patients with chronic heart failure with reduced ejection fraction

Fang

Lin

et al. 2021

View full text Add to dashboard Cite

OBJECTIVE: The aim of the present study was to observe the effect of sacubitril valsartan on cardiac function and vascular endothelial function in patients with chronic heart failure with reduced ejection fraction (HFrEF). METHODS: A total of 80 patients with HFrEF were randomly divided into an observation group and a control group, with 40 patients in each group. Sacubitril valsartan was added to the conventional treatment in the observation group, and perindopril was added to the conventional treatment in the control group. Both groups were treated continuously for 12 weeks. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), flow-mediated vasodilatory function (FMD) of the brachial artery, and levels of plasma Ang II, endothelin 1 (ET-1), and calcitonin gene-related peptide (CGRP), together with the serum nitric oxide (NO) and NO synthase (NOS) were compared before and after treatment in the groups. RESULTS: Before the treatment, the levels of LVEF, LVEDD, FMD, Ang II, ET-1, CGRP, NO, and NOS in the observation group were not significantly different from those in the control group (P > 0.05). However, the levels of LVEF, FMD, CGRP, NO, and NOS in both groups were significantly higher after the treatment than those before the treatment (P < 0.05) and significantly higher in the observation group than those in the control group. The difference was statistically significant (P < 0.05). Meanwhile, the levels of LVEDD, Ang II, and ET-1 in both groups decreased significantly after the treatment (P < 0.05) and were significantly lower in the observation group than those in the control group. The difference was statistically significant (P < 0.05). CONCLUSION: Sacubitril valsartan might improve endothelial function while increasing cardiac function in HFrEF patients.

show abstract

Renin-Angiotensin-Aldosterone System and Natriuretic Peptides as Possible Targets of Waon Therapy in Heart Failure

Cited by 3 publications

References 15 publications

Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease

Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease

Effect of Waon Therapy in Individuals With Heart Failure: A Systematic Review

Effect of sacubitril valsartan on cardiac function and endothelial function in patients with chronic heart failure with reduced ejection fraction

Contact Info

Product

Resources

About