Renin-aldosterone system in endotoxin shock in the dog

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Vasoactive hormones in endotoxin shock: A comparative study in cats and dogs

“…These results indirectly confirm the findings of White et al (1966) who observed a rise in plasma renin activity 10-20 min after administering endotoxin to dogs, at a time when both renal blood flow and blood pressure had fallen. Central venous pressure was not measured.…”

“…Activation of the kallikrein-kinin system in the rabbit has also been shown (Erdos & Miwa, 1968), and bradykinin levels have been found to be elevated in the monkey (Nies, Forsyth & Williams, 1968). White, Gold & Vaughn (1966) found a rise in plasma renin activity and aldosterone in the dog, the latter presumably being secondary to the generation of angiotensin.…”

Renal Vascular Resistance in Sepsis

“…Of 78 articles using flow probes [21, 22, 23, 24, 25, 26, 27, 28, 31, 32, 35, 41, 42, 45, 49, 50, 51, 52, 53, 54, 56, 58, 60, 62, 63, 65, 66, 69, 71, 72, 73, 74, 75, 78, 80, 81, 83, 85, 86, 89, 90, 91, 92, 95, 99, 100, 102, 106, 108, 109, 110, 111, 112, 113, 114, 115, 117, 118, 119, 121, 124, 126, 127, 128, 131, 135, 140, 141, 142, 143, 144, 145, 146, 152, 153, 154, 155], 36 (46.2%) showed a decreased RVR, 11 (14.1%) an unchanged RVR, and 31 (39.7%) a decreased RVR. Of 59 studies using other methods [20, 29, 30, 33, 34, 36, 37, 38, 39, 40, 43, 44, 4...…”

“…Among 39 ‘short’ experiments [25, 39, 40, 46, 52, 55, 57, 64, 69, 70, 72, 76, 78, 81, 88, 90, 94, 95, 101, 103, 104, 105, 107, 108, 112, 115, 125, 129, 130, 132, 133, 135, 136, 138, 140, 145, 146, 148,] 14 (35.9%) showed a decreased RVR, 4 (10.3%) no change in RVR, and 21 (53.8%) an increase in RVR. Among the 98 ‘long’ observation time studies [20, 21, 22, 23, 24, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 41, 42, 43, 44, 45, 47, 48, 49, 50, 51, 53, 54, 58, 59, 60, 61, 62, 63, 65, 66, 67, 68, 71, 73, 74, 75, 77, 79, 80, 82, 83, 84, 85, 86, …”

“…Of 95 articles using LPS [21, 22, 23, 24, 25, 26, 27, 28, 37, 38, 39, 41, 42, 43, 44, 45, 50, 54, 55, 56, 57, 58, 60, 62, 63, 65, 66, 69, 70, 72, 76, 77, 78, 79, 80, 81, 82, 83, 84, 86, 88, 89, 90, 93, 94, 95, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 121, 124, 125, 126, 127, 128, 130, 131, 132, 133, 135, 136, 137, 138, 139, 140, 142, 143, 144, 145, 146, 148, 152, …”