Renin‐Aldosterone Axis in Ethanol Intoxication and Hangover

Linkola, Jaakko; Fyhrquist, Frej; Nieminen, Markku M.; Weber, T.; Tontti, K

doi:10.1111/j.1365-2362.1976.tb00511.x

Cited by 44 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Present knowledge of osmoreceptors is insufficient to permit further evaluation of this problem. It should be, however, emphasized that ethanol doses used in this experiment may increase serum osrnolality about 17% (Linkola et a/. 1976).…”

Section: Discussionmentioning

confidence: 70%

“…Noradrenaline has been described to counteract the cellular actions of vasopressin at the level of cyclic AMP synthesis ( (Table 11). In a previous study (Linkola et a/. 1976) decrease of serum [K+] was observed during ethanol intoxication.…”

Section: Discussionmentioning

confidence: 83%

“…Increased serum "a+] (Wallgren and Barry 1970, Kissin and Begleiter 1971, Robertson et a/. 1976 and activated renin-angiotensin system (Linkola et a[. 1976, Keil et al 1975, Farmer and Fabre 1975 may stimulate AVP release during ethanol intoxication.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma vasopressin in ethanol intoxication and hangover

Linkola

Ylikahri

Fyhquist

et al. 1978

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

The effect of ethanol intoxication and hangover on immunoreactive plasma arginine vasopressin (AVP) concentration was studied in 7 healthy supine men in controlled clinical conditions. In 6 subjects plasma AVP increased above control values at the time of maximal blood ethanol concentration. The highest AVP values were observed in the subjects having nausea and vomiting and the worst hangover symptoms. During hangover plasma AVP values were higher than the controls and the response of plasma AVP to upright posture was exaggerated. The dissociation of plasma AVP concentration and ethanol diuresis suggested that the suppression of AVP release is not the sole determinant of ethanol diuresis. The study may indicate that the toxic effects of ethanol and the severity of hangover symptoms are associated with the state of hydration and individual sensitivity of AVP triggering mechanisms.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Plasma vasopressin in ethanol intoxication and hangover

Linkola

Ylikahri

Fyhquist

et al. 1978

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…The increase plasma renin was, probably, caused by dehydration due to ethanol diuresis or to the inhibiting action of the ethanol in the aldosterone secretion [85]. No significative change was found in the osmolarity, arterial pressure, and cardiac frequency.…”

Section: Alcohol and Hypertensionmentioning

confidence: 81%

Alcohol: Effects on Nutritional Status, Lipid Profile and Blood Pressure

Toffolo

2012

J Endocrinol Metab

View full text Add to dashboard Cite

Alcohol consumption can be the cause of several diseases. Depending on the frequency and quantity, the consumption of alcohol may increase the risk of malnutrition, weight-gain, obesity and cardiovascular diseases. The aim of this study was to review the influence of alcohol intake on nutritional status, lipid profile and blood pressure. The review shows that the additional consumption of ethanol calories will favor weight gain and metabolic changes and may engrave the risk of cardiovascular diseases, altering the lipid profile and promoting hypertension. Recommending a moderate use of alcohol with the purpose of taking advantage of its health benefits must not be done.

show abstract

“…4 Thus, alcohol intoxication and hangover have been reported to increase plasma renin activity, possibly due to dehydration. 32 An acute increase in renin activity was later confirmed with more moderate alcohol ingestion, and suggested to be secondary to alcohol-induced changes in fluid and electrolyte balance and BP, but not sympathetic activation. 33 With this in mind, it is interesting to note that losartan decreased LVH by ECG criteria most markedly in patients with high alcohol intake ( Figure 4).…”

Section: Discussionmentioning

confidence: 97%

Alcohol consumption and cardiovascular risk in hypertensives with left ventricular hypertrophy: the LIFE study

et al. 2004

View full text Add to dashboard Cite

The Losartan Intervention For End point reduction in hypertension (LIFE) study showed superiority of losartan over atenolol for reduction of composite risk of cardiovascular death, stroke, and myocardial infarction in hypertensives with left ventricular hypertrophy. We compared hazard ratios (HR) in 4287 and 685 participants who reported intakes of 1-7 and 48 drinks/week at baseline, respectively, with those in 4216 abstainers, adjusting for gender, age, smoking, exercise, and race. Within categories, clinical baseline characteristics, numbers randomized to losartan and atenolol, and blood pressure (BP) lowering were similar on the drug regimens. Overall BP control (o140/90 mmHg) at end of follow-up was similar in the categories. Composite end point rate was lower with 1-7 (24/1000 years; HR 0.87, Po0.05) and 48 drinks/week (26/1000 years; HR 0.80, NS) than in abstainers (27/1000 years). Myocardial infarction risk was reduced in both drinking categories (HR 0.76, Po0.05 and HR 0.29, Po0.001, respectively), while stroke risk tended to increase with 48 drinks/ week (HR 1.21, NS). Composite risk was significantly reduced with losartan compared to atenolol only in abstainers (HR 0.81 95% confidence interval, CI (0.68, 0.96), Po0.05), while benefits for stroke risk reduction were similar among participants consuming 1-7 drinks/ week (HR 0.73, Po0.05) and abstainers (HR 0.72, Po0.01). Despite different treatment benefits, alcoholtreatment interactions were nonsignificant. In conclusion, moderate alcohol consumption does not change the marked stroke risk reduction with losartan compared to atenolol in high-risk hypertensives. Alcohol reduces the risk of myocardial infarction, while the risk of stroke tends to increase with high intake.

show abstract

Renin‐Aldosterone Axis in Ethanol Intoxication and Hangover

Cited by 44 publications

References 17 publications

Plasma vasopressin in ethanol intoxication and hangover

Plasma vasopressin in ethanol intoxication and hangover

Alcohol: Effects on Nutritional Status, Lipid Profile and Blood Pressure

Alcohol consumption and cardiovascular risk in hypertensives with left ventricular hypertrophy: the LIFE study

Contact Info

Product

Resources

About