Renewal of Taste Bud Cells in Rat Circumvallate Papillae

Farbman, Albert I.

doi:10.1111/j.1365-2184.1980.tb00474.x

Cited by 184 publications

(220 citation statements)

References 18 publications

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“…The life span of taste cells is ϳ10 d in fungiform and vallate papillae of the adult rat (Beidler and Smallman, 1965;Farbman, 1980). Many mature taste cells are electrically excitable and are thought to develop from unexcitable, undifferentiated cells within the taste buds (Delay et al, 1986(Delay et al, , 1994.…”

Section: Postnatal Development and Cell Turnovermentioning

confidence: 99%

Postnatal Development of Membrane Excitability in Taste Cells of the Mouse Vallate Papilla

et al. 2002

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The mammalian peripheral taste system undergoes functional changes during postnatal development. These changes could reflect age-dependent alterations in the membrane properties of taste cells, which use a vast array of ion channels for transduction mechanisms. Yet, scarce information is available on the membrane events in developing taste cells. We have addressed this issue by studying voltage-dependent Na ϩ , K ϩ , and Cl Ϫ currents (I Na , I K , and I Cl , respectively) in a subset of taste cells (the so-called "Na/OUT" cells, which are electrically excitable and thought to be sensory) from mouse vallate papilla. Voltage-dependent currents play a key role during taste transduction, especially in the generation of action potentials. Patch-clamp recordings revealed that I Na , I K , and I Cl were expressed early in postnatal development. However, only I K and I Cl densities increased significantly in developing Na/OUT cells.Consistent with the rise of I K density, we found that action potential waveform changed markedly, with an increased speed of repolarization that was accompanied by an enhanced capability of repetitive firing. In addition to membrane excitability changes in putative sensory cells, we observed a concomitant increase in the occurrence of glia-like taste cells (the so called "leaky" cells) among patched cells. Leaky cells are likely involved in dissipating the increase of extracellular K ϩ during action potential discharge in chemosensory cells. Thus, developing taste cells of the mouse vallate papilla undergo a significant electrophysiological maturation and diversification. These functional changes may have a profound impact on the transduction capabilities of taste buds during development.

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Section: Postnatal Development and Cell Turnovermentioning

confidence: 99%

Postnatal Development of Membrane Excitability in Taste Cells of the Mouse Vallate Papilla

et al. 2002

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“…Zuker and colleagues (A. L. have suggested that activation of the "sweet" or "bitter" receptor cells, rather than taste receptor molecules per se, initiate the transfer of gustatory information to the CNS. It has previously been difficult to conceive how taste could be encoded through a labeled-line pattern, given the rapid turnover of taste cells within the taste bud (Farbman, 1980). How can a continuously remodeling system maintain a labeled-line pattern?…”

Section: -Ht Na and Tastementioning

confidence: 99%

Human Taste Thresholds Are Modulated by Serotonin and Noradrenaline

Heath

Melichar²,

Nutt³

et al. 2006

J. Neurosci.

171

150

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Circumstances in which serotonin (5-HT) and noradrenaline (NA) are altered, such as in anxiety or depression, are associated with taste disturbances, indicating the importance of these transmitters in the determination of taste thresholds in health and disease. In this study, we show for the first time that human taste thresholds are plastic and are lowered by modulation of systemic monoamines. Measurement of taste function in healthy humans before and after a 5-HT reuptake inhibitor, NA reuptake inhibitor, or placebo showed that enhancing 5-HT significantly reduced the sucrose taste threshold by 27% and the quinine taste threshold by 53%. In contrast, enhancing NA significantly reduced bitter taste threshold by 39% and sour threshold by 22%. In addition, the anxiety level was positively correlated with bitter and salt taste thresholds. We show that 5-HT and NA participate in setting taste thresholds, that human taste in normal healthy subjects is plastic, and that modulation of these neurotransmitters has distinct effects on different taste modalities. We present a model to explain these findings. In addition, we show that the general anxiety level is directly related to taste perception, suggesting that altered taste and appetite seen in affective disorders may reflect an actual change in the gustatory system.

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“…Four different types of cell have been characterized to constitute a taste bud; three taste-type cells (I, II and III) and one basal-type cells believed to be a progenitor of the other three (DeFazio et al 2006;Romanov and Kolesnikov 2006). Renewal of taste cells from the basal cells seems to occur every 10 to 15 d (Farbman 1980). Type I taste cells might be soursensing, while type II are the taste receptor cells for sweet, umami and bitter (DeFazio et al 2006;Romanov and Kolesnikov 2006).…”

Section: Taste (Gustation)mentioning

confidence: 99%

Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review

Roura¹,

Humphrey²,

Tedó³

et al. 2008

Can. J. Anim. Sci.

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Roura, E., Humphrey, B., Tedo´, G. and Ipharraguerre, I. 2008. Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review. Can. J. Anim. Sci. 88: 535Á558. The evolution of the chemical senses has resulted in a sensory apparatus for high taste and smell acuity in mammals and birds to ensure self-nourishment. Such peripheral chemosensory systems function as a code to unfold the nutritional value of feedstuffs. Food ingestion simultaneously evokes odor, taste and thermo-mechanical (somatosensing) sensations. Olfaction represents the capacity to identify feed volatiles that are predominantly derived from essential nutrients in plants.Comparative biology of olfaction shows that primates and chickens have a smaller olfactory epithelium and fewer olfactory receptor (OR) genes than non-primate mammals studied to date including farm and companion animals, such as the pig, the cow, the dog, the cat and the horse. A significant proportion of the total OR genes in mammals and birds have lost their functionality (pseudogenes) in a process that seems to reflect a decrease in the animal's reliance on the sense of smell, particularly in humans and cows. The taste system allows animals to recognize a diverse repertoire of nutrient (sugars, amino acids, salts, acids and fats) or toxic related chemical entities that provide valuable information about the quality of food. Taste senses non-volatile molecules in the oral cavity through taste receptors (TR). The TR are expressed in the sensory cells forming the taste buds of the tongue's papillae. Taste cells are linked to a network of solitary chemosensory cells diffused through many non-taste tissues involved in metabolic homeostasis. The number of functional taste receptor genes (TASR) in humans is equivalent to that in other mammals and superior to that in chickens. The TASR family 1 (TAS1R coding for umami and sweet TR) is conserved, in number and type, across the species evaluated, with the exception of the sweet receptor in chicken and feline species. The TASR family 2 (TAS2R coding for bitter TR) shows a strong adaptive capacity to dietary sources and digestive physiology across vertebrates. Pseudogenization (loss of gene functionality) in the TAS2R family seems to be a frequent strategy. The implications of oronasal nutrient sensing related to comparative animal feeding strategies and behaviors such as neophobia, feed refusal and hedonic preferences are discussed. Feed palatability and appetence might be one of the main driving forces in short-term feed consumption. Finally, practical applications relevant to animal production are outlined.Key words: Nutrient sensing, taste, olfaction, somatosensing, feed intake, farm, companion animals Roura, E., Humphrey, B., Tedo´, G. et Ipharraguerre, I. 2008. Le code de l'appe´tence a`court terme chez les animaux domestiques et de compagnie. Biologie comparative de la de´tection bucco-nasale des e´le´ments nutritifs. Can. J. Anim. Sci. 88: 535Á558. En e´voluant, ...

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Renewal of Taste Bud Cells in Rat Circumvallate Papillae

Cited by 184 publications

References 18 publications

Postnatal Development of Membrane Excitability in Taste Cells of the Mouse Vallate Papilla

Postnatal Development of Membrane Excitability in Taste Cells of the Mouse Vallate Papilla

Human Taste Thresholds Are Modulated by Serotonin and Noradrenaline

Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review

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