Renewal of extinguished cocaine-seeking

Hamlin, Adam; Clemens, Kelly J.; McNally, Gavan P.

doi:10.1016/j.neuroscience.2007.11.018

Cited by 153 publications

(151 citation statements)

References 54 publications

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“…Five rats were excluded from the analysis due to CTb injections spreading beyond the boundaries of either LH or PeF. The distribution of retrograde-labeled CTb-IR neurons after CTb injection into LH was similar to previous studies (Petrovich et al, 2001;Hamlin et al, 2008) and included prefrontal cortex, nucleus accumbens, paraventricular thalamus, ventral tegmental area, dorsal raphe, and locus ceruleus. Figure 3D shows a representative photomicrograph of Acb in rats with a CTb injection in LH, and Figure 3E shows a representative photomicrograph of Acb in rats with a CTb injection in PeF.…”

Section: Behaviorsupporting

confidence: 69%

“…Together, these findings show that LH is required for renewal of extinguished reward seeking. Previous experiments have shown an increase in c-Fos expression in LH neurons during renewal of extinguished sucrose (Hamlin et al, 2006), alcoholic beer (Hamlin et al, 2007), and cocaine seeking (Hamlin et al, 2008). These experiments show a causal role for LH in renewal across two different reward types, adding to a growing body of evidence that LH is important for learning about and responding to reward associated stimuli (Harris et al, 2005(Harris et al, , 2007.…”

Section: Discussionmentioning

confidence: 52%

“…used a renewal design (Bouton and Bolles, 1979) and reported that rats trained to self-administer a heroin-cocaine mixture in one context, context A, and then extinguished in a second, different context, context B, showed a pronounced reinstatement of extinguished drug seeking when tested in context A. This context-induced reinstatement or renewal of extinguished drug seeking has since been reported for a variety of drug rewards including cocaine Fuchs et al, 2007;Hamlin et al, 2008), heroin (Bossert et al, 2004), alcohol Zironi et al, 2006;Hamlin et al, 2007;Marinelli et al, 2007), and nicotine (Diergaarde et al, 2008), as well as the natural reward sucrose (Hamlin et al, 2006). Renewal is a signature phenomenon of extinction (Bouton, 2002).…”

Section: Introductionmentioning

confidence: 87%

“…This difference was due to more variable levels of responding during extinction training in the sucrose experiment. These parameters were chosen based on our past research which shows robust acquisition, extinction, and renewal of responding under these conditions (Hamlin et al, 2006(Hamlin et al, , 2007(Hamlin et al, , 2008. At the end of extinction training, rats were allocated, based on responding during acquisition and extinction training, to one of four groups: training context A (ABA) B/M, ABA PBS, extinction context B (ABB) B/M, or ABB PBS.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we have used c-Fos expression to identify the neural correlates of context-induced reinstatement. We have characterized these correlates for renewal of cocaine (Hamlin et al, 2008), alcoholic beer (Hamlin et al, 2007), and sucrose (Hamlin et al, 2006) seeking. In each case, renewal was selectively associated with c-Fos induction in lateral hypothalamus (LH).…”

Section: Introductionmentioning

confidence: 99%

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Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

2009

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We studied the role of lateral hypothalamus (LH) in context-induced reinstatement (renewal) of reward seeking. Rats were trained to respond for 4% (v/v) alcoholic beer or 10% (w/v) sucrose reward in one context (Context A) before extinction training in a second context (Context B). On test, rats were returned to the training context, A (ABA), or the extinction context, B (ABB). Return to the training context (ABA) produced robust reinstatement. Reversible inactivation of LH via baclofen/muscimol infusion prevented context-induced reinstatement of beer and sucrose seeking. This prevention was specific to bilateral infusions into LH. We then used the retrograde neuronal tracer cholera toxin b subunit (CTb) combined with detection of the c-Fos protein to identify activated afferents to LH during contextinduced reinstatement of beer seeking. Double labeling for c-Fos and CTb revealed a significant recruitment of LH-projecting neurons in nucleus accumbens shell (AcbSh) during reinstatement. These afferents could be classified into two anatomically and functionally distinct groups. First, afferents in the ventral AcbSh projecting to LH were activated during reinstatement. Second, afferents in the dorsomedial AcbSh projecting to LH were activated during test in the extinction context. These recruitments were specific to an AcbSh-LH pathway because they were not observed following CTb injection into the immediately adjacent perifornical hypothalamus. These results show that LH is critical for context-induced reinstatement of reward seeking and that parallel striatal-hypothalamic pathways are recruited following return to the training versus extinction contexts.

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Section: Behaviorsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

2009

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A translational analysis of ABA and ABC renewal of operant behavior

Liddon

Kelley

Rey

et al. 2018

J of App Behav Analysis

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Following reduction, behavior may recur when organisms are exposed to new or different environments. Such recurrences, called treatment relapse, are characterized by an increase of a previously reduced behavior. Renewal is a type of treatment relapse resulting from changes in stimulus contexts despite the ongoing maintenance of treatment. Renewal types include varying arrangements, such as ABA and ABC renewal, where each letter represents a different context. In the present series of translational analyses, we evaluated both ABA and ABC renewal and assessed whether these two renewal arrangements may be present in a single participant's behavior. Results produced evidence of both ABA and ABC renewal, and both types of renewal were detected in an individual participant's behavior.

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Comparison of prefrontal cortex sucrose seeking ensembles engaged in multiple seeking sessions: Context is key

Jessen

Bennett

Liu

et al. 2022

J of Neuroscience Research

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Encoding of memories, including those associated with prior drug or reward, is thought to take place within distinct populations of neurons, termed ensembles. Neuronal ensembles for drug‐ and reward‐seeking have been identified in regions of the medial prefrontal cortex, but much of our understanding of these ensembles is based on experiments that take place in a single reward‐associated environment and measure ensemble encoding over short durations of time. In contrast, reward seeking behavior is evident across different reward‐associated environments and persists over time. Using TetTag mice and Fos immunohistochemistry, we examined the relationship between persistent sucrose‐seeking and ensemble encoding in mice that undergo seeking sessions in the same or different sucrose self‐administration contexts 2 weeks apart. We found that prelimbic (PrL) and anterior cingulate cortex ensembles tagged in the first seeking session were highly sensitive to the context in which a second seeking session took place: reactivation of these ensembles was reduced in the same context but elevated in a distinct sucrose self‐administration context. Correlational analyses revealed that ensemble reactivation in the PrL was proportional to the persistence of sucrose seeking behavior across sessions in differing ways in female mice. In the same context, reactivation was proportional to the persistence of non‐reinforced operant responses, whereas in a distinct context, reactivation was proportional to the persistence of non‐reinforced head entries into the sucrose receptacle. This study underlines the importance of the medial prefrontal cortex importance in maintaining a reward‐seeking ensemble over time and identifies context‐dependent changes in behavioral correlates of ensemble reactivation.

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Renewal of extinguished cocaine-seeking

Cited by 153 publications

References 54 publications

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

A translational analysis of ABA and ABC renewal of operant behavior

Comparison of prefrontal cortex sucrose seeking ensembles engaged in multiple seeking sessions: Context is key

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