Renewal of an extinguished instrumental response: Neural correlates and the role of D1 dopamine receptors

Hamlin, Adam; Blatchford, Kate E.; McNally, Gavan P.

doi:10.1016/j.neuroscience.2006.07.035

Cited by 79 publications

(106 citation statements)

References 40 publications

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“…Together, these findings show that LH is required for renewal of extinguished reward seeking. Previous experiments have shown an increase in c-Fos expression in LH neurons during renewal of extinguished sucrose (Hamlin et al, 2006), alcoholic beer (Hamlin et al, 2007), and cocaine seeking (Hamlin et al, 2008). These experiments show a causal role for LH in renewal across two different reward types, adding to a growing body of evidence that LH is important for learning about and responding to reward associated stimuli (Harris et al, 2005(Harris et al, , 2007.…”

Section: Discussionmentioning

confidence: 53%

“…used a renewal design (Bouton and Bolles, 1979) and reported that rats trained to self-administer a heroin-cocaine mixture in one context, context A, and then extinguished in a second, different context, context B, showed a pronounced reinstatement of extinguished drug seeking when tested in context A. This context-induced reinstatement or renewal of extinguished drug seeking has since been reported for a variety of drug rewards including cocaine Fuchs et al, 2007;Hamlin et al, 2008), heroin (Bossert et al, 2004), alcohol Zironi et al, 2006;Hamlin et al, 2007;Marinelli et al, 2007), and nicotine (Diergaarde et al, 2008), as well as the natural reward sucrose (Hamlin et al, 2006). Renewal is a signature phenomenon of extinction (Bouton, 2002).…”

Section: Introductionmentioning

confidence: 78%

“…This difference was due to more variable levels of responding during extinction training in the sucrose experiment. These parameters were chosen based on our past research which shows robust acquisition, extinction, and renewal of responding under these conditions (Hamlin et al, 2006(Hamlin et al, , 2007(Hamlin et al, , 2008. At the end of extinction training, rats were allocated, based on responding during acquisition and extinction training, to one of four groups: training context A (ABA) B/M, ABA PBS, extinction context B (ABB) B/M, or ABB PBS.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we have used c-Fos expression to identify the neural correlates of context-induced reinstatement. We have characterized these correlates for renewal of cocaine (Hamlin et al, 2008), alcoholic beer (Hamlin et al, 2007), and sucrose (Hamlin et al, 2006) seeking. In each case, renewal was selectively associated with c-Fos induction in lateral hypothalamus (LH).…”

Section: Introductionmentioning

confidence: 99%

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Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

2009

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We studied the role of lateral hypothalamus (LH) in context-induced reinstatement (renewal) of reward seeking. Rats were trained to respond for 4% (v/v) alcoholic beer or 10% (w/v) sucrose reward in one context (Context A) before extinction training in a second context (Context B). On test, rats were returned to the training context, A (ABA), or the extinction context, B (ABB). Return to the training context (ABA) produced robust reinstatement. Reversible inactivation of LH via baclofen/muscimol infusion prevented context-induced reinstatement of beer and sucrose seeking. This prevention was specific to bilateral infusions into LH. We then used the retrograde neuronal tracer cholera toxin b subunit (CTb) combined with detection of the c-Fos protein to identify activated afferents to LH during contextinduced reinstatement of beer seeking. Double labeling for c-Fos and CTb revealed a significant recruitment of LH-projecting neurons in nucleus accumbens shell (AcbSh) during reinstatement. These afferents could be classified into two anatomically and functionally distinct groups. First, afferents in the ventral AcbSh projecting to LH were activated during reinstatement. Second, afferents in the dorsomedial AcbSh projecting to LH were activated during test in the extinction context. These recruitments were specific to an AcbSh-LH pathway because they were not observed following CTb injection into the immediately adjacent perifornical hypothalamus. These results show that LH is critical for context-induced reinstatement of reward seeking and that parallel striatal-hypothalamic pathways are recruited following return to the training versus extinction contexts.

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Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

2009

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“…Our observation is in agreement with the finding of Koya et al (2006), who have shown no increase in c-fos mRNA in the BLA following presentation of sucrosepaired cues. On the other hand, Hamlin et al (2006) have found that exposure to sucrose self-administration context activated c-Fos in the BLA, and Lee et al (2005) have reported that presentation of visual stimuli paired with food may induce c-Fos expression in the CeA. This ambiguous pattern of c-Fos expression found by different researchers could be interpreted in the way that natural rewardassociated cues may induce c-Fos in the BLA and CeA but to a lesser extent then drug-associated cues.…”

Section: Pattern Of C-fos Activation In the Amygdala: A Role In Plastmentioning

confidence: 98%

Alcohol Relapse Induced by Discrete Cues Activates Components of AP-1 Transcription Factor and ERK Pathway in the Rat Basolateral and Central Amygdala

Radwańska

Wróbel

Korkosz

et al. 2007

Neuropsychopharmacol

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Alcohol-related cues may induce relapse to heavy alcohol drinking and promote molecular adaptations in discrete brain regions. An exact nature of these molecular alterations is still unknown. In the present study, rats trained to self-administer ethanol were tested for cueinduced reinstatement of ethanol seeking after 30 days of abstinence. Next, a detailed immunocytochemical analysis of c-Fos activation was performed within seven nuclei of the amygdala. In the second experiment, c-Fos activation after reinstatement of ethanol seeking induced by discrete cues was compared with the activation pattern of its putative partner (c-Jun) and regulators (extracellular signalregulated kinases and c-Jun N-terminal kinases). Reexposure to ethanol-associated context cues (an extinction session) potentiated c-Fos expression within the basolateral and central amygdala. Repeated presentation of ethanol-associated discrete cues in an extinction/ reinstatement session led to even stronger c-Fos activation in the latter nuclei. In the second experiment, reexposure to the ethanolassociated context and discrete cues activated both c-Jun and extracellular signal-regulated kinases (ERK1/2) in the basolateral amygdala. Our observations suggest that the basolateral and central amygdala may be specifically involved in alcohol-seeking behavior induced by discrete cues.

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Renewal of extinguished operant behavior following changes in social context

Browning

Shahan

2018

J Exper Analysis Behavior

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Renewal is the reoccurrence of previously extinguished behavior following a change in the context in which extinction was conducted. Despite an extensive body of research examining renewal, little is known about the role of social stimuli in renewal. The present experiments provided a novel examination of renewal of operant behavior by changing social stimuli across phases in an ABA renewal preparation. In both experiments, social stimuli were arranged by placing another rat in a second compartment of a divided operant chamber. In Experiment 1, the presence of another rat defined the extinction context, whereas an empty second compartment defined the baseline and testing contexts. We reversed these contextual manipulations in Experiment 2 such that the presence of another rat defined the baseline and testing contexts and the second compartment was empty during extinction. Renewal of lever pressing occurred when the other rat was removed from the chamber in Experiment 1 and when the other rat was returned to the chamber in Experiment 2. Thus, social stimuli may function as contextual stimuli, and changes in social contexts may produce renewal of previously extinguished behavior.

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Renewal of an extinguished instrumental response: Neural correlates and the role of D1 dopamine receptors

Cited by 79 publications

References 40 publications

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

Alcohol Relapse Induced by Discrete Cues Activates Components of AP-1 Transcription Factor and ERK Pathway in the Rat Basolateral and Central Amygdala

Renewal of extinguished operant behavior following changes in social context

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