Renewable sorbent dispersive solid phase extraction automated by Lab-In-Syringe using magnetite-functionalized hydrophilic-lipophilic balanced sorbent coupled online to HPLC for determination of surface water contaminants

Gemuh, Celestine Vubangsi; Macháček, Miloslav; Solich, Petr; Horstkotte, Burkhard

doi:10.1016/j.aca.2022.339874

Cited by 16 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar procedure was developed using a commercial SupelTM-Select HLB (Hydrophilic modified styrene polymer) sorbent beads embedding magnetite nanoparticles (Fe 3 O 4 ) [ 39 ]. The sorbent was then used in a dispersive solid phase extraction procedure that was carried out entirely inside the void of an automatic syringe pump following the flow-batch concept of Lab-In-Syringe including automated renewal of the sorbent for each analysis.…”

Section: Resultsmentioning

confidence: 99%

Lab-in-Syringe, a Useful Technique for the Analysis and Detection of Pollutants of Emerging Concern in Environmental and Food Samples

2022

View full text Add to dashboard Cite

Lab-in-syringe is a new approach for the integration of various analytical extraction steps inside a syringe. Fully automated dispersive liquid–liquid microextraction is carried out in-syringe using a very simple instrumental setup. Dispersion is achieved by aspiration of the organic phase and then the watery phase into the syringe as rapidly as possible. After aggregation of the solvent droplets, the organic phase is pushed towards the detector allowing a highly sensitive spectrophotometric or fluorimetric detection. This technique is very useful not only for the preconcentration of analyte, but also for the elimination of their interferences. In this work, its application is described using solvents that are lighter and denser than water. The magnetically assisted variant and its coupling to different instruments has been also described with the aim of increasing the resolution of complex samples, especially useful for the determination of emerging contaminants.

show abstract

Section: Resultsmentioning

confidence: 99%

Lab-in-Syringe, a Useful Technique for the Analysis and Detection of Pollutants of Emerging Concern in Environmental and Food Samples

2022

View full text Add to dashboard Cite

show abstract

“…Table summarizes recent contributions to green sample preparation methods for environmental applications. ,,,− As observed in the case of bioanalysis, the use of liquid-based or solid-based extractions is equally applied. In this case, a preference for commercial sorbents is observed, with aqueous matrices being the choice of preference.…”

Section: Green Sample Preparation Applied To Environmental and Biolog...mentioning

confidence: 99%

“…Its contents can be instantly and uniformly mixed using a magnetic stir bar, setting it apart from most flow techniques. As an example, Gemuh et al 102 have developed an M-SPE by using commercial HLB coated to magnetite nanoparticles (NPs). The protocol was carried out in an automated syringe pump, which can renew the sorbent when necessary.…”

Section: Analyticalmentioning

confidence: 99%

Evolution of Green Sample Preparation: Fostering a Sustainable Tomorrow in Analytical Sciences

Martínez-Pérez-Cejuela,

Gionfriddo

2024

Anal. Chem.

View full text Add to dashboard Cite

“…Sample preparation plays a vital role in trace level determination of drugs in complex matrices [ 8 ]. In the past few years, various sample preparation methods have been reported for the determination of NSAIDs, such as solid-phase extraction (SPE), solid-phase microextraction (SPME), dispersive liquid–liquid microextraction (DLLME), liquid-phase microextraction (LPME), dispersive micro solid-phase extraction (DMSPE) and fabric phase sorptive extraction (FPSE) [ 9 , 10 , 11 , 12 ]. Additionally, new sorptive materials such as carbon nanotubes, magnetic nanoparticles, metal organic frameworks (MOFs), molecularly imprinted polymers (MIPs) and dendrimers have been synthesized and utilized in the above techniques for the extraction of NSAIDs from complex matrices [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Determination of Non-Steroidal Anti-Inflammatory Drugs in Urine Samples after In-Matrix Derivatization and Fabric Phase Sorptive Extraction-Gas Chromatography-Mass Spectrometry Analysis

Jain

Jain²,

Kabir³

et al. 2022

Molecules

View full text Add to dashboard Cite

Fabric phase sorptive extraction (FPSE) has become a popular sorptive-based microextraction technique for the rapid analysis of a wide variety of analytes in complex matrices. The present study describes a simple and green analytical protocol based on in-matrix methyl chloroformate (MCF) derivatization of non-steroidal anti-inflammatory (NSAID) drugs in urine samples followed by FPSE and gas chromatography-mass spectrometry (GC-MS) analysis. Use of MCF as derivatizing reagent saves substantial amounts of time, reagent and energy, and can be directly performed in aqueous samples without any sample pre-treatment. The derivatized analytes were extracted using sol–gel Carbowax 20M coated FPSE membrane and eluted in 0.5 mL of MeOH for GC-MS analysis. A chemometric design of experiment-based approach was utilized comprising a Placket–Burman design (PBD) and central composite design (CCD) for screening and optimization of significant variables of derivatization and FPSE protocol, respectively. Under optimized conditions, the proposed FPSE-GC-MS method exhibited good linearity in the range of 0.1–10 µg mL−1 with coefficients of determination (R2) in the range of 0.998–0.999. The intra-day and inter-day precisions for the proposed method were lower than <7% and <10%, respectively. The developed method has been successfully applied to the determination of NSAIDs in urine samples of patients under their medication. Finally, the green character of the proposed method was evaluated using ComplexGAPI tool. The proposed method will pave the way for simper analysis of polar drugs by FPSE-GC-MS.

show abstract

Renewable sorbent dispersive solid phase extraction automated by Lab-In-Syringe using magnetite-functionalized hydrophilic-lipophilic balanced sorbent coupled online to HPLC for determination of surface water contaminants

Cited by 16 publications

References 46 publications

Lab-in-Syringe, a Useful Technique for the Analysis and Detection of Pollutants of Emerging Concern in Environmental and Food Samples

Lab-in-Syringe, a Useful Technique for the Analysis and Detection of Pollutants of Emerging Concern in Environmental and Food Samples

Evolution of Green Sample Preparation: Fostering a Sustainable Tomorrow in Analytical Sciences

Rapid Determination of Non-Steroidal Anti-Inflammatory Drugs in Urine Samples after In-Matrix Derivatization and Fabric Phase Sorptive Extraction-Gas Chromatography-Mass Spectrometry Analysis

Contact Info

Product

Resources

About