Rendimiento diagnóstico de marcadores tumorales séricos convencionales en pacientes con sospecha clínica de cáncer primario metastásico a hígado

Arias-Flórez, Juan Sebastián; Martínez-Delgado, Angélica María; Alarcón-Tarazona, Martha Liliana; Insuasty, Jesús; Díaz‐Martínez, Luis Alfonso

doi:10.4067/s0034-98872018001201422

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…AFP and CA199 are commonly used tumor markers for the diagnosis of liver cancer. Although the detection of the two marker levels is simple, the detection sensitivity and specificity are not high [ 27 , 28 ]. Therefore, missed diagnosis can easily occur because these two serum markers are highly expressed not only in liver cancer patients, but also in many other malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

Kong

Jiang²,

Sun

et al. 2022

Journal of Healthcare Engineering

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Background. Early screening and diagnosis are of great significance to the treatment and prognosis of patients with liver cancer. This study aims to explore the application value of contrast-enhanced ultrasound and enhanced CT combined with tumor markers alpha-fetoprotein (AFP) and carbohydrate antigen 199 (CA199) in the diagnosis of liver cancer. Methods. Liver cancer group (n = 256), benign disease group (n = 110), and control group (n = 50) participated in this study. The liver cancer and benign disease groups were diagnosed pathologically by contrast-enhanced ultrasound and enhanced CT before operation. The electrochemiluminescence method was used to detect the content of AFP and CA199. And the receiver operating characteristic (ROC) curve was drawn. Results. The detection rate of contrast-enhanced ultrasound is higher than that of enhanced CT. Serum levels of AFP and CA199 in the liver cancer group were significantly higher than those in the benign lesion group and the control group. The ROC curve showed that the sensitivity, accuracy, and negative prediction rate of contrast-enhanced ultrasound and enhanced CT combined with tumor markers AFP and CA199 in the diagnosis of liver cancer were significantly higher than that of a single test. Conclusion. The combined detection of contrast-enhanced ultrasound and enhanced CT, AFP, and CA199 significantly improved the sensitivity and accuracy of liver cancer diagnosis. It has a significant effect on the early diagnosis of liver cancer and can be used as an important means of early screening.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

Kong

Jiang²,

Sun

et al. 2022

Journal of Healthcare Engineering

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“…En cuanto a los exámenes de laboratorio que se indican para estos casos: la biometría hemática muestra cifras bajas de hemoglobina (anemia), la eritrosedimentación está acelerada; salen alteradas las pruebas de función hepática y renal, el coagulograma, sobre todo si hay lesión hepática metastásica y la lámina periférica, por presencia de células malignas. (7,8) Los marcadores tumorales en sangre, por su parte, no solo orientan hacia el diagnóstico de neuroblastoma ya que indican la presencia de esta enfermedad, sino que, luego del tratamiento, se indican con valor pronóstico en el seguimiento de los pacientes para detectar recaídas o recidivas tumorales: (9,10) • LDH > 500 U/L…”

Section: • Dolores óSeos O Muscularesunclassified

Tumores abdominales en la infancia

Saraguro¹,

Jumbo²,

Velarde³

et al. 2023

Afecciones Clínico-Quirúrgicas Frecuentes en La Infancia

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Potential anti-proliferative activity of Salix mucronata and Triticum spelta plant extracts on liver and colorectal cancer cell lines

Ahmad

Serie²,

Abdel-Latif

et al. 2023

Sci Rep

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Cancer’s etiology is linked to oxidative stress. As a result, it's vital to find effective natural antioxidant remedies. Salix mucronata and Triticum spelta plant extracts were prepared using five different solvents and examined for their cytotoxicity against liver HepG2 cancer cell line. It was found that Salix mucronata ethanolic extract is high in antioxidant mediated anti-cancer activity. The functional constituents (phenolic and flavonoids) as well as preparation of different ethanolic concentrations used to study their properties that include DPPH, oxygen, hydroxyl, nitrogen radical scavenging activities, ferric reducing power and metal chelating activities. The MTT assay was used to determine antioxidant-mediated anti-cancer activity against human liver (HepG2) and colorectal (Caco-2) cancer cells to calculate the half-maximal growth inhibitory concentration (IC50). Moreover, flow cytometry analysis was used to quantify the apoptotic effect on the treated cancer cells. Additionally, qRTPCR of p53, BCL2, Cyclin D, MMP9 and VEGF were measured. Furthermore, HPLC was used to assess the most effective ingredients of the plant extract. Salix mucronata 50% ethanol extract had the highest polyphenolic content, anti-oxidant, and anti-proliferative activity. Salix mucronata increased the number of total apoptotic cells, and caused an upregulation of p53 gene expression by more than five folds and a downregulation of gene expression level of BCL2, Cyclin D, MMP9 and VEGF by more than five folds. Consequently, that could modulate oxidative stress and improve the effectiveness of cancer therapy. Results, also, showed that Triticum spelta ethanolic extract was less effective than Salix mucronata. Therefore, Salix mucronata ethanolic extract represents promising surrogate natural therapy for apoptosis-mediated cancer and recommended for further investigation using animal model.

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Rendimiento diagnóstico de marcadores tumorales séricos convencionales en pacientes con sospecha clínica de cáncer primario metastásico a hígado

Cited by 3 publications

References 6 publications

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer

Tumores abdominales en la infancia

Potential anti-proliferative activity of Salix mucronata and Triticum spelta plant extracts on liver and colorectal cancer cell lines

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