Renaut bodies in the sciatic nerve of beagle dogs

Elcock, Laura E.; Stuart, Barry P.; Hoss, H.; Crabb, Kerry; Millard, Donna M.; Bopp, Bill; Mueller, Robert E.; Hastings, Thomas F.; Lake, Stephen G.

doi:10.1078/0940-2993-00157

Cited by 23 publications

(35 citation statements)

References 17 publications

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“…In peripheral nerve disease states, they mostly do not increase or decrease in prominence and have therefore been neglected during the last decades. Renaut bodies contain fusiform or stellate cells mostly identified as fibroblasts (Ortman et al, 1983;Weis et al, 1993;Ortiz-Hidalgo and Weller, 1996;Skidmore et al, 1996;Elcock et al, 2001) together with specific oval, ruff-like cells, which have been termed ''cellules godronées'' (Renaut, 1881a,b), ''Blasenzellen,'' ''Krausenzellen'' or ''chordoid cells'' (Schaffer, 1933;Patzelt, 1948), ''Gitterzellen'' (Bargmann, 1967). It is still not clear whether the cells of Renaut bodies are of endoneurial (Asbury, 1973;Ortman et al, 1983;Hill and Hall, 1999) or perineurial origin (Nagao et al, 1995;Ortiz-Hidalgo and Weller, 1996;Skidmore et al, 1996).…”

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“…The extracellular matrix of Renaut bodies consists of fibrillar material, e.g., elastic and oxytalan fibers, basement membrane material, and collagen fibrils (Salonen et al, 1985;Weis et al, 1993;Skidmore et al, 1996;Elcock et al, 2001), as well as acidic proteoglycans (Nagao et al, 1995;Ortiz-Hidalgo and Weller, 1996).…”

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“…Renaut bodies are described to develop as a physiological adaptation in response to mechanical stress imposed on nerves. They were first described in nerves of the human sole (Renaut, 1881a,b) but are found at other sites of peripheral nerve entrapment or compression as well, e.g., in the sciatic nerve and its branches, in the interosseous nerves or the median nerve (Jefferson et al, 1981;Hill and Hall, 1999;Elcock et al, 2001). Apparently, Renaut bodies can also develop in connection with systemic diseases, such as hypothyroidism and mastocytosis (Dines et al, 1999).…”

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Renaut bodies in nerves of the trunk of the African elephant, Loxodonta africana

Witter

Egger

Boeck

2007

Journal of Morphology

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Renaut bodies are loosely textured, cell-sparse structures in the subperineurial space of peripheral nerves, frequently found at sites of nerve entrapment. The trunk of the elephant is a mobile, richly innervated organ, which serves for food gathering, object grasping and as a tactile organ. These functions of the trunk lead to distortion and mechanical compression of its nerves, which can therefore be expected to contain numerous Renaut bodies. Samples of the trunk wall of an adult African elephant (Loxodonta africana) were examined histologically using conventional staining methods, immunohistochemistry, and lectin histochemistry. Architecture of nerve plexuses and occurrence of Renaut bodies in the elephant trunk were compared with those in tissues surrounding the nasal vestibule of the pig. Prominent nerve plexuses were found in all layers of the elephant trunk. Almost all (81%) nerve profiles contained Renaut bodies, a basophilic, discrete subperineurial layer resembling cushions around the nerve core. In contrast, Renaut bodies were seen in only 15% of nerve profiles in the porcine nasal vestibule. Within Renaut bodies, fusiform fibroblasts and round, ruff-like cells were placed into a matrix of acidic glycosaminoglycans with delicate collagen and very few reticular fibers. The turgor of this matrix is thought to protect nerves against compression and shearing strain. Renaut bodies are readily stained with alcian blue (pH 2.5) favorably in combination with immunohistochemical markers of nerve fibers. They should be regarded as a physiological response to repeated mechanical insults and are distinct from pathological alterations. alterations.

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Renaut bodies in nerves of the trunk of the African elephant, Loxodonta africana

Witter

Egger

Boeck

2007

Journal of Morphology

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“…People with entrapment neuropathy of the deep peroneal nerve suffer from pain, paresthesia, and numbness of the foot 22 . Other investigators have theorized that Renaut bodies are a physiologic adaptation to repeated mechanical stress imposed on nerves 23 . The presence of Renaut bodies in the excised segments of the DBLPN suggests that the DBLPN is at least stressed, if not compressed, in horses suffering from PSD of the pelvic limbs.…”

Section: Discussionmentioning

confidence: 99%

Compressive Damage to the Deep Branch of the Lateral Plantar Nerve Associated with Lameness Caused by Proximal Suspensory Desmitis

et al. 2008

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“…Renaut bodies in peripheral nerves primarily consist of fibroblasts that are thought to proliferate as a physiological reaction to mechanical stresses (Elcock et al, 2001). While Renaut bodies have been reported mainly at sites of nerve compression in man and horses (Duncan et al, 1987;Piña-Oviedo et al, 2009), these constituted common incidental findings in healthy dogs (Whitney et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

A Histopathological Study of Bovine Ganglia

Jahns

Fast

2014

Journal of Comparative Pathology

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One hundred and sixty-eight ganglia from 54 cattle aged 10 days to 10 years were examined microscopically. Samples from six autonomic ganglia and one sensory ganglion were represented. Thirteen animals were clinically normal and 41 were submitted for post-mortem examination. Neuronal vacuolation, spheroid formation, lipofuscin accumulation and central chromatolysis were observed sporadically and were of varying magnitude. Neuronal vacuolation and spheroid formation were not age-related changes, while lipofuscin accumulation was more common in older animals and central chromatolysis was more common in younger cattle. Non-suppurative inflammation and neuronophagia were also common findings (23 out of 54 animals, 42.6%) in autonomic ganglia that did not contain herpesvirus DNA as determined by polymerase chain reaction. Renaut bodies, features of peripheral nerves, were most commonly noted in the vagus. None of the histopathological findings were related to any particular disease in which loss of autonomic nervous system function might be expected. Furthermore, all changes were as common in clinically normal animals as in animals with disease.

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Renaut bodies in the sciatic nerve of beagle dogs

Cited by 23 publications

References 17 publications

Renaut bodies in nerves of the trunk of the African elephant, Loxodonta africana

Renaut bodies in nerves of the trunk of the African elephant, Loxodonta africana

Compressive Damage to the Deep Branch of the Lateral Plantar Nerve Associated with Lameness Caused by Proximal Suspensory Desmitis

A Histopathological Study of Bovine Ganglia

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