Renaut bodies in the hind limb nerves of cattle with downer cow syndrome

Ohfuji, S.

doi:10.1007/s00580-018-2665-x

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…2,9 Supporting the idea of a link with mechanical stress, these structures have been found in the peripheral nerves of a range of species over the years, including man, elephant, dog, hamster, rat, and cattle. 4,5,7,[10][11][12][13][14] The nerves in which they were found were usually located in anatomical areas naturally susceptible to such stress and injury, for instance, the peripheral nerves of the elephant's trunk, which is used as a prehensile organ 11 or classically at the site of entrapment of median and ulnar nerves in man. 5,10 Furthermore, as in the currently acknowledged hypothesis, RBs could be successfully induced in animals undergoing mechanical stress, such as repeated mechanical trauma or compression.…”

Section: Discussionmentioning

confidence: 99%

Unusual Incidence and Location of Renaut Bodies in Beagle Dogs in a Nonclinical Study

2020

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We identified the presence of Renaut bodies in an unusual location in Beagle dogs on a 3-month nonclinical toxicity study. These peculiar structures are commonly reported as a background finding in the sciatic nerve of dogs. In our study, however, they were also observed in autonomic nerves surrounding the adrenal gland, a location in which they have not been reported before. The incidence in both locations were 8 of 32 Beagle dogs in the sciatic nerve and 6 of 40 Beagle dogs around the adrenal gland in the dosing and/or recovery phases of the study.

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