Renalase, A Novel Regulator of Blood Pressure, Is Predicted by Kidney Function in Renal Transplant Recipients

Renalase — a new marker or just a bystander in cardiovascular disease: clinical and experimental data

“…This results are in conflict with the data published by Xu et al [1]. Renalase was measured with the use of different techniques -Xu used Western blot technique with polyclonal antibodies, Malyszko based results on commercially available ELISA assay with monoclonal antibody specific for renalase [12,29]. Serum renalase was also higher in peritoneal dialysis patients than in healthy control group and its concentration correlated positively with the time of dialysis but there was no correlation between blood pressure control nor residual renal function [30].…”

“…Xu et al [1] as well as Wu et al [12], in small group of patients with end-stage renal disease, measured decreased renalase expression compared to healthy volunteers. Malyszko et al [29] observed, in a group of 89 kidney transplant recipients, higher renalase concentration than in healthy volunteers. Renalase level was related to kidney function, age, time after transplantation, and blood pressure.…”

Is Renalase a Novel Player in Catecholaminergic Signaling? The Mystery of the Catalytic Activity of an Intriguing New Flavoenzyme

“…Moreover, the involvement of renalase in the modulation of the catecholaminergic system has become increasingly clear. Thus, human renalase is now regarded as a new player in the control of blood pressure and heart function, whose modulation could lead to promising new pharmacological treatments of various cardiovascular dysfunctions [3,8,13,23,24,70,71].…”

“…A renalase concentration of 0.1 mg per gram wet tissue has been estimated in the kidneys by immunoblotting [10]. Data on the absolute concentration of renalase in human blood plasma have been explicitly reported only recently, as determined by ELISA, showing that it is about 4 g/ml in healthy individuals, corresponding to 0.1 M [23][24][25][26][27][28]. Murine renalase gene expression was observed by reverse transcriptase PCR in kidney, testicle, liver, heart, 12.5-days whole embryo, brain, and skeletal muscle [16].…”

“…Recent studies on the impact of kidney and heart transplantation on the level of circulating renalase led to the unexpected finding that plasma renalase concentration increases after organ implantation and the degree of increase correlates with the severity of kidney failure in the allograft recipients [23][24][25].…”