Renal venous thrombosis in infancy: Long-term follow-up

Abstract

Sixteen children (11 male, 5 female) who developed renal venous thrombosis in the neonatal period or early infancy have been followed for periods varying from 29 months to 16 years (median 12 years) after initial diagnosis. Twelve patients presented with a hyperosmolar state, and in 4 the illness was preceded by severe birth asphyxia. The diagnosis was based on the findings of clinical and/or radiological renal enlargement (15 cases), haematuria (16 cases) and elevation in plasma urea (16 cases). Thrombocytopenia (13 cases), red cell fragmentation (13 cases) and oliguria (13 cases) were frequent associated findings. All 16 patients survived the acute illness, 1 patient died 3 years later from an unrelated event. On follow-up evaluation, 11 patients have normal renal function (glomerular filtration rate greater than 80 ml/min per 1.73 m2), 5 developed hypertension, 2 of whom responded to unilateral nephrectomy. Urinary concentrating capacity was subnormal (less than 800 mosmol/kg) in 7 of the 15 cases studied. Follow-up renal imaging studies were undertaken in 14 patients, and the imaging procedure was normal in only 2 of these. Of the remainder, 8 showed unilateral abnormality and 4 bilateral abnormality. Intellectual development was normal in 12 patients, mildly impaired in 1, and severely impaired in 3.

Antithrombotic Therapy in Neonates and Children

“…14,278 Overall survival now approaches 100%. [278][279][280][281][282] Clinical sequelae in survivors include chronic renal impairment and hypertension. [278][279][280][281][282][283] Lau et al 279 reviewed all Englishlanguage reports of neonatal RVT from 1992 to 2006.…”

Thromboembolic Disease and Antithrombotic Therapy in Newborns

“…Almost 80% of all RVT present within the first month and usually within the first week of life. 2,[30][31][32] Some newborns developed RVT in utero. 32 The incidence in males and females is similar, both sides are affected equally, and RVT occurs bilaterally in 24% of newborns.…”

Clinical outcome of umbilical artery catheter-related thrombosis—a cohort study

“…It is noteworthy that previous studies on renal vein thrombosis 28 and pediatric ischemic stroke 29 found a male predominance. In our cases, all female infants who had UACRT had a BW of <1 kg, whereas male infants had a wide BW range.…”