Renal vein thrombosis complicating primary hyperparathyroidism

Smallman, Lesley A.

doi:10.1136/pgmj.58.681.441

Cited by 3 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are some case reports of thrombotic events associated with PHPT in which high serum calcium is accused of being a causative factor. In those cases, renal vein thrombosis and dermal necrosis due to thrombosis were encountered during the course of hyperparathyroidism [10,16,17]. Thrombotic events were reported also in SHPT [17].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Hyperparathyroid State on Platelet Functions and Bone Loss

Yorulmaz

Akalın²,

Akay³

et al. 2016

Tjh

View full text Add to dashboard Cite

Objective:Coagulation and fibrinolysis defects were reported in primary hyperparathyroid patients. However, there are not enough data regarding platelet functions in this group of patients. Our aim was to evaluate the platelet functions in primary and secondary hyperparathyroid patients and to compare them with healthy subjects.Materials and Methods:In our study 25 subjects with primary hyperparathyroidism (PHPT), 25 subjects with secondary hyperparathyroidism (SHPT), and 25 healthy controls were included. Platelet functions of the subjects were evaluated by using platelet-rich plasma and platelet aggregation tests induced with epinephrine, adenosine diphosphate (ADP), collagen, and ristocetin. Serum P selectin levels, which indicate platelet activation level, were measured in all subjects. Bone mineral densitometry was performed for all patients.Results:There was no significant difference between the groups with PHPT and SHPT and the control group regarding the platelet aggregation tests and serum P selectin levels. There was also no significant correlation between parathormone levels and aggregation parameters (ristocetin, epinephrine, collagen, and ADP: respectively p=0.446, 0.537, 0.346, and 0.302) and between P selectin (p=0.516) levels. When we separated the patients according to serum calcium levels, there was also no significant difference between aggregation parameters and serum P selectin levels between the patients with hypercalcemia and the patients with normocalcemia. We could not find any significant correlation between aggregation parameters, P selectin levels, and serum calcium levels in this group of patients. Bone loss was greater in patients with PHPT.Conclusion:There is no significant effect of PHPT or SHPT and serum calcium levels on platelet functions when evaluated by aggregation tests.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Hyperparathyroid State on Platelet Functions and Bone Loss

Yorulmaz

Akalın²,

Akay³

et al. 2016

Tjh

View full text Add to dashboard Cite

show abstract

“…It is likely that the hypercalcaemia noted on admission was related to the incidental parathyroid adenoma, exacerbated by the sepsis-related dehydration. Although there have been documented cases of renal vein thrombosis occurring in hyperparthyroidism, 9 no direct association has been previously described in the literature between splenic infarction and hyperparathyroidism.…”

Section: An Unusual Cause Of Septicaemiamentioning

confidence: 97%

An Unusual Cause of Septicaemia

Nadarajah

Saif²,

Asghar³

2011

Acute Med

View full text Add to dashboard Cite

Splenic infarction occurs when occlusion of splenic vasculature leads to ischemia, and subsequent tissue necrosis. It is a rare condition. Most patients have an underlying haematological or malignant process or a potential source of embolism. This article describes a patient who presented with unexplained sepsis to the acute medical unit; investigation revealed a splenic abscess and primary hyperparathyroidism, but no evidence of an underlying cause.

show abstract

Lethal Renal Venous Thrombosis Complicating Dehydration in Infancy

Byard

2019

Am J Forensic Med Pathol

View full text Add to dashboard Cite

A 3-month-old boy presented to hospital in cardiac arrest, dehydrated, with a blood sodium of 158.4 mmol/L. He had been febrile, not feeding normally and refusing fluids. Despite attempts at resuscitation with rehydration, he was declared dead. At autopsy, the kidneys were uniformly enlarged with thrombi within intraparenchymal tributaries of the renal veins bilaterally. Death was due to bilateral renal venous system thrombosis with hypernatremic dehydration. It is likely that the dehydration resulted both from increased requirements for fluid due to fever and from inadequate oral intake. Lethal renal venous thrombosis is a rare multifactorial condition that should be suspected in all infants with histories of hypernatremic dehydration with hypotension. Although there may be no obvious renal vein thrombosis at the time of dissection, microscopy may reveal intraparenchymal venous thromboses. As inherited prothrombotic states are associated with renal venous thrombosis, hematologic evaluation of immediate family members would be in order.

show abstract

Renal vein thrombosis complicating primary hyperparathyroidism

Cited by 3 publications

References 7 publications

The Effect of Hyperparathyroid State on Platelet Functions and Bone Loss

The Effect of Hyperparathyroid State on Platelet Functions and Bone Loss

An Unusual Cause of Septicaemia

Lethal Renal Venous Thrombosis Complicating Dehydration in Infancy

Contact Info

Product

Resources

About