Renal Vascular Structure and Rarefaction

Chade, Alejandro

doi:10.1002/cphy.c120012

Cited by 107 publications

(110 citation statements)

References 161 publications

(249 reference statements)

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“…57 From the long-term perspective, postinsult recovery of the peritubular capillary network may prevent chronic tubulointestinal hypoxia and fibrosis. 58 Therefore, the therapeutic potential of strategies targeting vascular repair and regeneration, such as angiogenic factors, and stem or progenitor cell populations is worthy of further preclinical testing.…”

Section: Targets To Protect the Nephrovascular Unitsmentioning

confidence: 99%

Renal Hemodynamics in AKI

Matějovič

İnce

Chawla

et al. 2016

Journal of the American Society of Nephrology

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Novel therapeutic interventions are required to prevent or treat AKI. To expedite progress in this regard, a consensus conference held by the Acute Dialysis Quality Initiative was convened in April of 2014 to develop recommendations for research priorities and future directions. Here, we highlight the concepts related to renal hemodynamics in AKI that are likely to reveal new treatment targets on investigation. Overall, we must better understand the interactions between systemic, total renal, and glomerular hemodynamics, including the role of tubuloglomerular feedback. Furthermore, the net consequences of therapeutic maneuvers aimed at restoring glomerular filtration need to be examined in relation to the nature, magnitude, and duration of the insult. Additionally, microvascular blood flow heterogeneity in AKI is now recognized as a common occurrence; timely interventions to preserve the renal microcirculatory flow may interrupt the downward spiral of injury toward progressive kidney failure and should, therefore, be investigated. Finally, development of techniques that permit an integrative physiologic approach, including direct visualization of renal microvasculature and measurement of oxygen kinetics and mitochondrial function in intact tissue in all nephron segments, may provide new insights into how the kidney responds to various injurious stimuli and allow evaluation of new therapeutic strategies.

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Section: Targets To Protect the Nephrovascular Unitsmentioning

confidence: 99%

Renal Hemodynamics in AKI

Matějovič

İnce

Chawla

et al. 2016

Journal of the American Society of Nephrology

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“…Not all vessels are perfused under conditions of normal metabolic demand (Chade, 2013). Consequently, non-perfused microvasculature represents a reserve that may be recruited under conditions of stress (Levy et al, 2008).…”

Section: Age-related Anatomical and Functional Changes In The Micmentioning

confidence: 99%

The effect of aging on the cutaneous microvasculature

Bentov

Reed

2015

Microvascular Research

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Aging is associated with a progressive loss of function in all organs. Under normal conditions the physiologic compensation for age-related deficits is sufficient, but during times of stress the limitations of this reserve become evident. Explanations for this reduction in reserve include the changes in the microcirculation that occur during the normal aging process. The microcirculation is defined as the blood flow through arterioles, capillaries and venules, which are the smallest vessels in the vasculature and are embedded within organs and tissues. Optimal strategies to maintain the microvasculature following surgery and other stressors must use multifactorial approaches. Using skin as the model organ, we will review the anatomical and functional changes in the microcirculation with aging, and some of the available clinical strategies to potentially mitigate the effect of these changes on important clinical outcomes.

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“…Long-term changes in renal blood flow, for example during essential hypertension, may induce progressive modifications in the microvascular (MV) tone, given that the chronic vascular constriction can lead to peritubular capillary loss and increased intrarenal vascular resistance. The severity of these changes may affect the kidney functions, a phenomenon known as vascular rarefaction [3]. Carvedilol is a beta blocker with antioxidant and vasodilating activities, which has proven to provide renal protection in experimental rat models, beyond their antihypertensive activity [4].…”

mentioning

confidence: 99%