Renal Type Clear Cell Carcinoma of the Prostate: A Diagnostic Dilemma

Permi, Harish S.; Laxminarayana, Kishan Prasad Hosapatna; Yeshvanth, Sunil Kumar; Shetty, Jyothi

doi:10.4103/0974-2727.86853

Cited by 9 publications

(11 citation statements)

References 2 publications

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“… Pal & Chowdhury (2007) [ 3 ] 64 2.1 ng/L TURP Clear cell carcinoma similar to RCC Mucicarmine staining for intracytoplasmic mucin : negative Positive: Pancytokeratin, Vimentin and EMA No evidence of pelvic lymph node metastasis (12 months) Negative: PSA, PSAP and HMWCK 3. Permi et al (2011) [ 4 ] 64 82 ng/ml TURP followed by radical cystoprostatectomy + pelvic lymph node dissection Clear cell carcinoma similar to RCC Not done Not done No evidence of recurrence (12 months) 4. Wang et al (2015) [ 5 ] 64 10.2 ng/ml TURP Clear cell carcinoma similar to RCC and typical prostatic adenocarcinoma (Gleason’s score 4 + 4) Not done Positive: LMWCK, Vimentin, EMA, CD10, PSAP and AMACR Death due to multiorgan failure (6 months) Negative: HMWCK, CEA, Broad spectrum cytokeratin and PAX8 5.…”

Section: Case Presentationmentioning

confidence: 99%

Renal-type clear cell carcinoma of the prostate: a diagnostic challenge

et al. 2015

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A 72-year-old male presented with urinary symptoms. His serum prostate specific antigen level was 65.2 ng/ml. His radical prostatectomy specimen showed clear cell lesion reminiscent of the clear cell renal cell carcinoma along with acinar type of prostatic adenocarcinoma, Gleason score 4 + 4. The lesional clear cells were positive for pancytokeratin, epithelial membrane antigen, CD10, vimentin, and AMACR while negative for 34βE12, CK7, prostate specific antigen, and PAX8. The final diagnosis was renal-type clear cell carcinoma of the prostate. A follow-up of 20 months did not show metastasis. We herein report fifth case of renal-type clear cell carcinoma of the prostate.

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Section: Case Presentationmentioning

confidence: 99%

Renal-type clear cell carcinoma of the prostate: a diagnostic challenge

et al. 2015

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“…Lastly, several case reports have documented a possible entity labelled “renal‐type clear‐cell carcinoma”, found exclusively in the prostate 25–31 . Although such cases may potentially be considered primary E‐RCCs occurring in the prostate, the interpretation of such cases warrants caution.…”

Section: Discussionmentioning

confidence: 99%

Extrarenal renal cell carcinoma arising in the kidney proximity but without an identifiable renal primary – an intriguing dilemma: report of three cases and review of the literature

et al. 2022

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AimTo raise awareness of the existence of extrarenal renal cell carcinoma (RCC).Methods and resultsWe report three patients with extrarenal RCC found in the renal proximity, but unattached to the kidney. None had a history of RCC or an identifiable primary renal neoplasm at the time of the diagnosis and on follow‐up. The patients included two males and one female aged 57, 77, and 63 years, respectively. One carcinoma was found in the perirenal tissue adjacent to the adrenal, one involved the adrenal gland, and one was a retroperitoneal mass found within the lymph nodes. Two extrarenal RCCs represented clear‐cell RCCs and one was an unclassifiable RCC. No patient had evidence of metastases at presentation and disease progression during the follow‐up. This report adds to the literature on this unusual clinical scenario and further supports the concept of extrarenal RCC, which is not a well‐recognized clinical phenomenon. We also reviewed other similar reports documenting the absence of identifiable renal primaries in the setting of either disseminated metastatic disease or isolated distant metastases of presumed renal origin. Similarly, some carcinomas of apparent renal derivation have been also identified during a work‐up of metastatic carcinomas of unknown primary.ConclusionsThere should be an awareness of this unusual and intriguing clinical scenario that currently lacks a definitive explanation and standardized therapy strategies. Establishing a correct diagnosis may allow treatment with specific targeted therapies in selected clinical cases.

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“…The immunohistochemical staining results showed that RCC had positive Pan-cytokeratin (Pan-CK), LMWCK, and PSAP and negative HMWCK, vimentin, PSA, CEA, CK7, and CK20. The RTCCCs of the prostate reported thus far generally showed positivity for vimentin, CD10, LMWCK, EMA, MME, and AMACR; partial positivity for PSA, PSAP, AMACR, and Pan-CK; and negativity for HMWCK, CEA, and PAX8 (2,(7)(8)(9)(10)(11)(12). RCC is asymptomatic in its early stages and its metastasis to the prostate is extremely rare; thus, metastatic RCC can be differentially diagnosed if renal lesions are not observed on ultrasonographic and computed tomography (CT) scans of the abdomen (7,10).…”

Section: Discussionmentioning

confidence: 99%

Rare Case of Renal-type Clear Cell Carcinoma of the Prostate and Review of the Literature

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2020

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Renal Type Clear Cell Carcinoma of the Prostate: A Diagnostic Dilemma

Cited by 9 publications

References 2 publications

Renal-type clear cell carcinoma of the prostate: a diagnostic challenge

Renal-type clear cell carcinoma of the prostate: a diagnostic challenge

Extrarenal renal cell carcinoma arising in the kidney proximity but without an identifiable renal primary – an intriguing dilemma: report of three cases and review of the literature

Rare Case of Renal-type Clear Cell Carcinoma of the Prostate and Review of the Literature

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