Renal tumors in young adults

Boykin, William H.; Bright, Kevin E.; Zeidman, Eric J.; Thompson, Ian M.

doi:10.1016/0090-4295(92)90402-i

Cited by 18 publications

(23 citation statements)

References 7 publications

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“…We conclude that renal cell carcinoma may exhibit a more favorable prognosis in young adults when diagnosed at low stage. Higher stages seem to possess a biologic potential similar to that seen in older adult patients [5]. …”

Section: Discussionmentioning

confidence: 88%

Influence of Age on the Prognosis of Patients with Renal Cell Carcinoma (RCC)

Yusim

Mermershtain²,

Neulander³

et al. 2002

Oncol Res Treat

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Objective: Aim of this study was to analyze the prognostic value of age in patients with renal cell carcinoma (RCC). Patients and Methods: A group of 15 patients (age ≤ 40 years, group I) and a group of 103 patients (age ≧ 50 years, group II) with sporadic RCC who underwent radical nephrectomy between 1985 and 1997 were compared. The two groups were analyzed with respect to histologic cell type, tumor grade, stage and outcome. Results: In group I low-stage tumors (stage I and II) were diagnosed in 93% of patients and in group II in 65% of the patients (p = 0.017). High-grade tumors (stage III and IV) were diagnosed in 7% and 35% of patients in group I and group II, respectively (p < 0.01). In group I only one patient (7%) with stage II disease died of cancer. In group II the distribution of cancer-specific mortality was as follows: 6 patients (100%) with stage IV, 13 patients (42%) with stage III, and 12 patients (17%) with stage I and II died of disease. The 5-year-survival in group I was 93% and in group II was 77% (p = 0.05). Conclusion: According to our data we conclude that RCC is diagnosed at a lower stage in young patients than in the older patient group. RCC may exhibit a more favorable prognosis in young patients, possible due to the lower stage at time of diagnosis.

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Section: Discussionmentioning

confidence: 88%

Influence of Age on the Prognosis of Patients with Renal Cell Carcinoma (RCC)

Yusim

Mermershtain²,

Neulander³

et al. 2002

Oncol Res Treat

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“…Recently, some investigators have observed that the spectrum of renal tumours in young adults is markedly diVerent from that seen in older adults, and hence their presenting features, pathological proWle, biological behaviour and clinical outcome are diVerent (Lopez et al 2010;Taccoen et al 2007;Denzinger et al 2007;Cao et al 2005;Eggener et al 2004;Goetzl et al 2004;Boykin et al 1992;Abou El Fettouh et al 2002;Renshaw et al 1999;Rainwater et al 1991;Sanchez-Ortiz et al 2004). We have earlier reported in a preliminary study the spectrum of the renal tumours in an unselected small group of adults from Pakistan (Latif et al 2011).…”

Section: Introductionmentioning

confidence: 88%

Histopathology of surgically treated renal tumours in young adults: a developing country perspective

Mubarak

Kazi

Mohsin

et al. 2011

J Cancer Res Clin Oncol

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“…Some authors emphasized that pT status at diagnosis is the best parameter for predicting survival [14] . Interestingly, a high proportion of patients with OCD, approximately 80-85%, were detected in several series [6,7,12,13,15,18,19] . These percentages are quite similar to the 83.6% found in our series.…”

Section: Discussionmentioning

confidence: 99%

“…Only approximately 3-7.5% of all RCCs arise in patients ! 40 years of age [4,5,7,12,14,17,18] . Table 3 lists all previously reported series dealing with this subset of RCCs.…”

Section: Discussionmentioning

confidence: 99%

“…Since then some other studies have appeared comparing RCCs in patients younger and older than 40 years, respectively [6,[10][11][12][13][15][16][17][18] . While some authors stated that RCCs behaved better in younger than in older patients [7,10,13,17,18] , with longer survivals, others found no marked differences [4,11,14,16,19] . Further studies are needed to completely delineate the exact clinical significance of RCCs in young people.…”

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confidence: 97%

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Renal Cell Carcinoma in Young Adults: A Study of 130 Cases and a Review of Previous Series

López

Moreno²,

Garcia³

et al. 2010

Urol Int

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Objective: To characterize a large series of renal cell carcinomas (RCCs) in young patients and to compare the data obtained to previously published data. Patients and Methods: A total of 130 RCCs diagnosed in patients <40 years of age were collected from 9 different hospitals in Spain. Cases were re-evaluated following the diagnostic criteria of the 2004 WHO classification of renal tumors. Results: Histologically, tumors were classified as clear cell (50.7%), papillary (8.5%), chromophobe (14.6%), unclassified (16.9%) and clear cell papillary (9.3%) RCCs. Organ-confined disease (OCD) was detected in 83.6% of the cases. Tumor size and Fuhrman’s grade were statistically correlated (Spearman’s ρ = 0.391). CD10 (p = 0.000), CK7 (p = 0.000), CD15 (p = 0.016), CD117 (p = 0.000), 34βE12 cytokeratin (p = 0.034) and e-cadherin (p = 0.000) immunostaining significantly differentiated the five histological categories. Conclusions: OCD was more common in young RCC patients. The clear cell phenotype accounted for only 50% of RCCs in this age group, with an increasing number of chromophobe and unclassified RCCs. Clear cell RCCs with a papillary growth pattern accounted for a significant proportion of the cases.

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Renal tumors in young adults

Cited by 18 publications

References 7 publications

Influence of Age on the Prognosis of Patients with Renal Cell Carcinoma (RCC)

Influence of Age on the Prognosis of Patients with Renal Cell Carcinoma (RCC)

Histopathology of surgically treated renal tumours in young adults: a developing country perspective

Renal Cell Carcinoma in Young Adults: A Study of 130 Cases and a Review of Previous Series

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