Renal tubular function in patients treated with high-dose cisplatin

Daugaard, Gedske; Abildgaard, Ulrik; Holstein‐Rathlou, Niels‐Henrik; Bruunshuus, Ivan; Bucher, Ditlef; Leyssac, P. P.

doi:10.1038/clpt.1988.132

Cited by 120 publications

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“…12 In a study conducted on 30 patients, in whom three cures of high-dose cisplatin treatment were administered (40 mg/m 2 /day during 5 days), proteinuria, albuminuria and aminoaciduria were observed in each treatment cure. 13 Likewise, proteinuria was significantly observed in both groups on the þ5th day after cisplatin administration in our study as well. More proteinuria was observed in the group without theophylline intake.…”

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confidence: 80%

The efficacy of theophylline in preventing cisplatin-related nephrotoxicity in patients with cancer

et al. 2016

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Objective: Cisplatin is a potent antineoplastic agent used and its major limiting side effect is nephrotoxicity. The aims of the study are early detection of acute kidney injury (AKI) with biomarkers and investigation of the potential nephron-protective effects of theophylline. Methods: Glomerular filtration rates (GFR), neutrophil gelatinase-associated lipocalin (NGAL), cystatin C were measured at 5th day of treatment in all of the patients. In addition, these parameters were measured repeatedly after the administration of cisplatin, at 2nd hour, 5th and 20th days. Patients: Sixty patients who are planned to receive cisplatin for the first time were included in the study. Patients were divided into two groups as Group 1 (n ¼ 30) (standard treatment arm) and Group II (n ¼ 30) (theophylline arm). Results: In both groups after the administration of cisplatin, GFR showed a significant decrease within time (p ¼ 0.006). Urine NGAL levels were significantly high after 2 h of cisplatin administration (p < 0.001), no significant difference was observed between groups. However, when the time*group effects were considered together, higher NGAL levels were detected in the group not receiving theophylline (p ¼ 0.025). After 5 days of cisplatin administration, urine protein levels were significantly higher in both groups (p < 0.001). Conclusion: Results showed that urine NGAL level is a superior biomarker compared to serum creatinine and serum cystatin C in the detection of early AKI. Theophylline was found not to bring a complete protection for the kidneys, but less nephrotoxicity was developed when compared to the group not receiving theophylline. ARTICLE HISTORY

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confidence: 80%

The efficacy of theophylline in preventing cisplatin-related nephrotoxicity in patients with cancer

et al. 2016

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“…It might also result from renal loss due to the use of diuretics or to tubular injury provoked by drugs such as cisplatin and ifosfamide. 32 In addition, fluid retention caused by heart failure and hypoalbuminemia may lead to dilutional hyponatremia, as well as in some types of neoplasms (lymphomas and leukemias) due to the development of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). 33 Cyclophosphamide may also be related to SIADH.…”

Section: Hyponatremiamentioning

confidence: 99%

Suporte de terapia intensiva no paciente oncológico

Sapolnik¹

2003

J. Pediatr. (Rio J.)

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Objective: To review the most important aspects of the clinical presentation and treatment of children with cancer in intensive care units. Medline (1970Medline ( to 2003; search terms: children, cancer, oncology, intensive care, complications. General and pediatric oncology textbooks. Sources of data: Summary of the findings:Practically all organs may be affected by cancer or by its treatment. The main complications include infections, hematological problems and electrolyte/ metabolic disturbances. Intensive care therapy is necessary to correct organic dysfunctions (cardiovascular, respiratory, renal, gastrointestinal, and neurologic). Nutritional and emotional support, as well as pain control are fundamental aspects for recovery in children. The intensivist should be alert to interrupt intensive care measures if required. Conclusions:Many studies show that the use of intensive care therapy in children with cancer is not futile, with a reduction in mortality and improvement in the quality of life of these children in the medium and long terms.

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“…Nephrotoxicity of cisplatin may result in increased magnesium (Mg) excretion (Mavichak et al, 1985;Stewart et al, 1985;Ariceta et al, 1997), even before renal function becomes affected (Daugaard et al, 1988). The lack of clear-cut symptoms in most patients with even profoundly reduced levels of plasma (P)-Mg has left it uncertain whether Mg substitution should be instituted when the value is low.…”

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confidence: 99%

Severe intracellular magnesium and potassium depletion in patients after treatment with cisplatin

et al. 2003

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The purpose of this study is (1) to evaluate skeletal muscle magnesium (Mg) and potassium (K) during treatment with cisplatin; (2) to evaluate the predictive value of plasma (P)-Mg for intracellular Mg during cisplatin treatment; and (3) to evaluate whether changes in intracellular K influence skeletal muscle Na,K-ATPase. In all, 65 patients had a needle muscle biopsy obtained before and 26 patients both before and after cisplatin treatment. Biopsies were analysed for Mg, K, and Na,K-ATPase concentrations, and P-Mg and P-K determined. Treatment with a total dose of E500 mg (270 mg [K] were not associated with changes in the muscle Na,K-ATPase concentration. Following treatment with cisplatin, an E15% decline in P-Mg was accompanied by an E15% loss of muscle [Mg], as well as an E10% reduction of muscle [K] and fatigue and muscle weakness previously ascribed to hypomagnesaemia may therefore also be well explained by muscle K depletion observed despite normal levels of P-K. There was no correlation between P-Mg and SM-Mg or between P-K and SM-K. Thus, P-Mg and P-K are not reliable indicators for Mg and K depletion during treatment with cisplatin. However, the majority of patients will present Mg and K depletion after cisplatin therapy and of these only very few patients will present a low P-Mg or P-K. Therefore, routine supplementation should be considered in all patients receiving cisplatin.

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Renal tubular function in patients treated with high-dose cisplatin

Cited by 120 publications

References 0 publications

The efficacy of theophylline in preventing cisplatin-related nephrotoxicity in patients with cancer

The efficacy of theophylline in preventing cisplatin-related nephrotoxicity in patients with cancer

Suporte de terapia intensiva no paciente oncológico

Severe intracellular magnesium and potassium depletion in patients after treatment with cisplatin

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