Renal Tubular Dysfunction in Pediatric Urolithiasis: Proteomic Evidence

Kovačević, Larisa; Lu, Hong; Caruso, Joseph A.; Lakshmanan, Yegappan

doi:10.1016/j.urology.2016.02.003

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…In a similar fashion, CaOx and CaP crystals have been shown to dissolve within lysosomes following binding and internalization of cultured renal cells [13], but the involvement of CHMP was not described. Indeed, none of the endosomal proteins we found in CYS were part of the urinary proteomes of our patients with nephrolithiasis and hypercalciuria [14], nor were described by others in patients with hyperoxaluria [15], indicating their unique significance in CYS.…”

Section: Discussioncontrasting

confidence: 64%

“…Of those, 18/38 were circulating inflammatory proteins (e.g., complement C3 and C8; fibrinogen alpha, beta, and gamma chain; and serum paraoxonase 1), and 14/38 were derived from neutrophils. Additionally, significant inflammation was found in the urine proteome of patients with nephrolithiasis and hypercalciuria [14], and type 1 primary hyperoxaluria [15]. Altogether, these findings indicate that inflammation plays an important role in the pathogenesis of kidney stone disease irrespective of its metabolic cause.…”

Section: Discussionmentioning

confidence: 79%

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Urine proteomic profiling in patients with nephrolithiasis and cystinuria

Kovačević

Caruso

et al. 2018

Int Urol Nephrol

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declares that she has no conflict of interest. Joseph A. Caruso declares that he has no conflict of interest. Hong Lu declares that she has no conflict of interest. Natalija Kovacevic declares that she has no conflict of interest. Yegappan Lakshmanan declares that he has no conflict of interest. Nicholas J. Carruthers declares that he has no conflict of interest. David S. Goldfarb declares that he has no conflict of interest. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent: The urine was obtained for routine urinalysis for clinical care, and would have then been discarded; it was sent to the proteomics laboratory without any personal health identification information. Under these circumstances, analysis of the urine is not considered human subjects research. and therefore informed consent was not required from the participants included in the study.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 79%

Urine proteomic profiling in patients with nephrolithiasis and cystinuria

Kovačević

Caruso

et al. 2018

Int Urol Nephrol

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“…Urinary tract stones are one of the most important causes of kidney failure and urinary tract congestion (2). Ureteral calculi are important than other types of urinary tract stones in terms of the severity of symptoms and the speed at which kidney failure is developed (3). Transurethral lithotripsy (TUL) is one of the techniques to treat ureteral calculi.…”

Section: Introductionmentioning

confidence: 99%

Comparision of hemodynamic changes, movement, duration of surgery and pain between lateral and supine posision after spinal anesthesia in transurethral lithotrips

et al. 2018

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Introduction: Patient position during surgery is an important issue that can affect vital indices. Objectives: This study was conducted to compare hemodynamic changes, movements, surgery length, and pain during transurethral lithotripsy (TUL) in supine and lateral positions. Patients and Methods: This double-blind clinical trial was conducted on 76 patients who were candidate for TUL, randomized to two groups of 38 for each. In the lateral group, after inducing spinal anesthesia, the patients were positioned lateral and in supine group, the patients were positioned supine immediately after injecting anesthetic. Vital signs were recorded at six intervals; 5 minutes before anesthesia and 1, 5, 10, 15, and 20 minutes after anesthesia. In addition, movements and pain during surgery were assessed. Data analysis was conducted by descriptive statistics, independent t test, and repeated measures ANOVA in SPSS 22. Results: There were significant differences in changes in systolic blood pressure, diastolic blood pressure, and mean arterial pressure at different intervals between the two groups in such a way that hemodynamic stability was greater in the lateral group (P<0.05). There were no significant differences in changes in heart rate at all studied intervals between the two groups (P>0.05). Surgery length, movement and pain during surgery were not significantly different between the two groups (P < 0.05). Conclusion: Hemodynamic changes especially blood pressure were less remarkable in patients undergoing spinal anesthesia in TUL at lateral position than those in supine position. Additionally, no significant differences in patients’ movement and surgery, and surgery length between the two positions was detected.

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“…Kidney stones affect up to 5% of the population, with a lifetime risk of passing a kidney stone of about 8-10% [1]. Crystallization alone is not enough to explain the formation of renal stones.…”

Section: Introductionmentioning

confidence: 99%

Degradation, Characterization, Ferrous Ion Chelating Ability and Repair Effect of Sulfated Polysaccharides of Six Kinds of Seaweed Polysaccharides

Sun¹,

Guo²,

Wang³

et al. 2018

Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)

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Abstract. Six kinds of seaweed polysaccharides (SPSs) extracted from Laminaria japonica, Porphyra yezoensis, Gracilaria lemaneiformis, Sargassum fusiforme, Eucheuma gelatinae and Undaria pinnatifida were degraded and characterized. The sulfate group (-OSO 3 H) content of these polysaccharides were 21.7, 17.9, 13.3, 8.2, 7.0, and 5.5%, respectively. The ferrous ion chelating ability and repair effect on injured human kidney proximal tubular epithelial cells (HK-2) of these polysaccharides were studied. These polysaccharides had stronger ferrous ion chelating ability, suggesting that it possessed high antioxidant activity. Each polysaccharide had a repair effect on oxalate-induced damaged HK-2 cells. The antioxidant activity and repair ability of polysaccharide was positively correlated with its -OSO 3 H content. These results indicated that these polysaccharides, especially those with high -OSO 3 H content, may be potential drugs for the prevention and treatment of calcium oxalate stones.

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Renal Tubular Dysfunction in Pediatric Urolithiasis: Proteomic Evidence

Cited by 9 publications

References 22 publications

Urine proteomic profiling in patients with nephrolithiasis and cystinuria

Urine proteomic profiling in patients with nephrolithiasis and cystinuria

Comparision of hemodynamic changes, movement, duration of surgery and pain between lateral and supine posision after spinal anesthesia in transurethral lithotrips

Degradation, Characterization, Ferrous Ion Chelating Ability and Repair Effect of Sulfated Polysaccharides of Six Kinds of Seaweed Polysaccharides

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