Renal tubular damage may contribute more to acute hyperglycemia induced kidney injury in non-diabetic conscious rats

Wang, Jingyu; Yang, Juhong; Xu, Jie; Jia, Junya; Zhang, Xinrong; Yue, Xiaodan; Chen, Liming; Shan, Chunyan; Zheng, Miaoyan; Han, Fei; Zhang, Yi; Yang, Xiaoyun; Chang, Baocheng

doi:10.1016/j.jdiacomp.2015.04.014

Cited by 28 publications

(32 citation statements)

References 43 publications

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“…NGAL filtered by the glomerulus will be captured by proximal tubules and only a minimal amount is excreted in the urine. Tubular injury results from ischemia, inflammation, and hyperglycemia leads to a decrease in NGAL reabsorption and an increase in NGAL secretion by tubular cells [17]. CysC is produced in all nucleated cells, and is a 13.4-kDa cysteine protease inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Performance of urinary neutrophil gelatinase-associated lipocalin, clusterin, and cystatin C in predicting diabetic kidney disease and diabetic microalbuminuria: a consecutive cohort study

Zeng

Lyu

et al. 2017

BMC Nephrol

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BackgroundTubular biomarkers have been regarded as emerging and promising markers for early diagnosis of diabetic kidney disease (DKD). The study was to determine the diagnostic capabilities of tubular biomarkers (urinary neutrophil gelatinase-associated lipocalin [NGAL], clusterin, and cystatin C) for DKD and diabetic microalbuminuria, and whether or not the tubular biomarkers appear earlier than microalbuminuria.MethodsIn this consecutive cohort study, 146 type 2 diabetes mellitus (T2DM) patients with a disease duration of ≥6 years were enrolled. Thirty age- and gender-matched subjects without any systemic diseases were recruited as the control group. Urinary samples collected before treatment were tested for NGAL, clusterin, and cystatin C.ResultsThe levels of biomarkers were higher in patients with DKD (p < 0.001); and positively correlated with the urinary albumin creatinine ratio (UACR; p < 0.001). With respect to the diagnosis of DKD, the areas under the receiver operating characteristic curve (AUCs) for urinary NGAL, clusterin, and cystatin C were 0.816 (95% confidence interval [CI], 0.741–0.891), 0.775 (95% CI: 0.694–0.857), and 0.803 (95% CI: 0.722–0.884), respectively. The levels of urinary NGAL and cystatin C in the normoalbuminuria group (UACR <30 mg /g•Cr) were elevated compared with the control group, unlike urinary clusterin. There was no statistical difference in the levels of the three biomarkers between groups with different levels of haemoglobin A1C (HbA1c). The diagnostic AUCs for urinary NGAL, clusterin, and cystatin C in patients with diabetic microalbuminuria were 0.841 (95% CI: 0.775–0.907), 0.783(95% CI: 0.710–0.856), and 0.805 (95% CI: 0.733–0.877), respectively.ConclusionsUrinary NGAL, clusterin, and cystatin C may be promising biomarkers for diagnosing DKD and diabetic microalbuminuria. It is possible that urinary NGAL and cystatin C increase before the onset of microalbuminuria in T2DM patients.

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Section: Introductionmentioning

confidence: 99%

Performance of urinary neutrophil gelatinase-associated lipocalin, clusterin, and cystatin C in predicting diabetic kidney disease and diabetic microalbuminuria: a consecutive cohort study

Zeng

Lyu

et al. 2017

BMC Nephrol

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“…There exist several explanations of the relationship between stress hyperglycaemia and AKI. [20][21][22] Furthermore, stress hyperglycaemia may induce osmotic diuresis, resulting in the reduction in volume and increased risk of prerenal azotemia as well as AKI. The defective insulin secretion worsens hyperglycaemia, in particular, in CKD population.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase‐9, 10, and stress hyperglycaemia in acute kidney injury

Guvercin

Karakuş

Akşit

et al. 2018

Eur J Clin Investigation

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“…The renal tubule is responsible for the reabsorption, secretion, and excretion of many important molecules and is susceptible to various kinds of harmful factors because of its structural and functional characteristics . Renal tubular epithelial cells contain large amounts of mitochondria to meet their energy requirements, which increases the sensitivity of epithelial cells to ischemia, anoxia, and oxidative stress injuries .…”

Section: Discussionmentioning

confidence: 99%

Long‐term renal tubular damage in intrauterine growth‐restricted rats

Murano

Shoji

Hara

et al. 2018

Pediatrics International

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Renal tubular damage may contribute more to acute hyperglycemia induced kidney injury in non-diabetic conscious rats

Cited by 28 publications

References 43 publications

Performance of urinary neutrophil gelatinase-associated lipocalin, clusterin, and cystatin C in predicting diabetic kidney disease and diabetic microalbuminuria: a consecutive cohort study

Performance of urinary neutrophil gelatinase-associated lipocalin, clusterin, and cystatin C in predicting diabetic kidney disease and diabetic microalbuminuria: a consecutive cohort study

Matrix metalloproteinase‐9, 10, and stress hyperglycaemia in acute kidney injury

Long‐term renal tubular damage in intrauterine growth‐restricted rats

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