Renal Tubular Acidosis

Böckenhauer, Detlef; Lopez-Garcia, Sergio Camilo; Walsh, Stephen B.

doi:10.1007/978-3-030-52719-8_111

Cited by 2 publications

(2 citation statements)

References 136 publications

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“…Distal renal tubular acidosis may result from impaired urinary acidification due to low concentration of urinary sodium (Santos et al 2015;Bockenhauer et al 2022). However, in rotavirus gastroenteritis, viremia occurs at a high rate when fever is observed (Sugata et al 2008), and urinary β2-MG is elevated without an increase in serum β2-MG levels (Yokoyama et al 2010;Morita and Fujieda 2011).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

An Infant Case of Transient Distal Renal Tubular Acidosis and Fanconi Syndrome Caused by Rotavirus Gastroenteritis

Kumagai,

Matsuki,

Nakayama

2023

Tohoku J. Exp. Med.

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We report an infant case of transient distal renal tubular acidosis and Fanconi syndrome caused by rotavirus gastroenteritis. A 10-month-old boy was admitted to the hospital because of frequent vomiting, lack of vitality, and dehydration. He was diagnosed with rotavirus gastroenteritis based on his positive stool rotavirus antigen test. Although he presented with acidemia and severe mixed metabolic acidosis, he also had a urine pH of 6.0, indicating impaired urinary acidification. Therefore, he was diagnosed with renal tubular acidosis. On the third day of hospitalization, a relatively low %tubular reabsorption of phosphate level with hypophosphatemia, increased fractional excretion of uric acid with hypouricemia, and high urinary β2-microglobulin levels were observed.Moreover, he was diagnosed with Fanconi syndrome on the account of multiple proximal tubular dysfunctions. After remission of rotavirus gastroenteritis, the signs of renal tubular dysfunction improved. This was a case of rotavirus gastroenteritis-caused transient distal renal tubular acidosis and Fanconi syndrome. Severe metabolic acidosis was resulted from anion-gap metabolic acidosis due to acute kidney injury by rotavirus gastroenteritis and normal anion-gap acidosis due to renal tubular acidosis. When renal tubular acidosis is associated with a disease that causes anion-gap metabolic acidosis, mixed metabolic acidosis occurs and becomes exacerbated. Furthermore, it is important A c c e p t e d M a n u s c r i p t 4 to consider the complications of renal tubular acidosis in the case of severe metabolic acidosis.

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Section: Accepted Manuscriptmentioning

confidence: 99%

An Infant Case of Transient Distal Renal Tubular Acidosis and Fanconi Syndrome Caused by Rotavirus Gastroenteritis

Kumagai,

Matsuki,

Nakayama

2023

Tohoku J. Exp. Med.

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“…A compressão dos vasos sanguíneos renais devido ao excesso de gordura ao redor dos rins pode ainda agravar a situação, comprometendo o suprimento sanguíneo renal e a função do órgão117 . Neste trabalho, evidenciamos que uma dieta hipercalórica elevou os níveis de sódio, potássio e creatinina no sangue, indicando disfunção renal, correspondendo a achados em pacientes obesos119,120 . Intrigantemente, a administração de nebivolol reverteu esses efeitos, sugerindo um papel renoprotetor deste fármaco.…”

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Efeitos pleiotrópicos do nebivolol sobre a disfunção vascular e mecanismos inflamatórios do tecido adiposo perivascular na hipertensão secundária à obesidade

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Renal Tubular Acidosis

Cited by 2 publications

References 136 publications

An Infant Case of Transient Distal Renal Tubular Acidosis and Fanconi Syndrome Caused by Rotavirus Gastroenteritis

An Infant Case of Transient Distal Renal Tubular Acidosis and Fanconi Syndrome Caused by Rotavirus Gastroenteritis

Efeitos pleiotrópicos do nebivolol sobre a disfunção vascular e mecanismos inflamatórios do tecido adiposo perivascular na hipertensão secundária à obesidade

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