Renal Tubular Acidosis After Kidney Transplantation

Wilson, Douglas R.; Siddiqui, Abdullah

doi:10.7326/0003-4819-79-3-352

Cited by 56 publications

(30 citation statements)

References 24 publications

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“…Type 1 classic distal RTA has been reported more frequently in kidney recipients. 2,3,5,[8][9][10] Similarly, in this study, we observed that the presence of distal RTA was higher compared with other types of RTA.…”

Section: Discussionsupporting

confidence: 66%

“…3,5 Similarly, mean creatinine clearance was significantly lower in acidosis group than that in nonacidosis group in our study. Also serum hemoglobin level was significantly lower in acidosis group compared to the nonacidosis group.…”

Section: Discussionmentioning

confidence: 49%

“…[5][6][7] However, information about the prevalence, clinical importance, and risk factors of metabolic acidosis in long-term allograft recipients is poor. In this study, prevalence of metabolic acidosis was found to be 31.8% in stable kidney allograft recipients.…”

Section: Discussionmentioning

confidence: 99%

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Renal tubular acidosis in renal transplantation recipients

et al. 2010

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Aim: We aimed to investigate the prevalence, type, and possible risk factors of renal tubular acidosis (RTA) in Turkish patients with renal transplantation. Patients and method: The study included 66 adult renal transplantation recipients. We recorded the parameters of venous blood gas analysis including serum pH value, serum bicarbonate (HCO 3 ) concentration, presence of metabolic acidosis, which was defined as low HCO 3 (<22 mEq/L), and serum pH value (<7.35) together, and base excess and urine pH at the last follow-up. Creatinine clearance was determined from 24-hour collected urine samples. RTA was defined to be metabolic acidosis with normal serum anion gap and positive urine anion gap. Results: Mean age of 66 patients was 37.0 ± 10.4 years; 48 of 66 patients were male. RTA was found in 14 (21.2%) patients. Considering for differential diagnosis of RTA, 4 patients had type 2 RTA and 10 had type 1 RTA. On the contrary, type 4 RTA was observed in no patients. Creatinine clearance was meaningfully lower in acidosis group than in those of the nonacidosis group (55.16 ± 23.27 vs. 71.06 ± 28.14 mL/min; p = 0.028). HCO 3 was correlated with hemoglobin level (r = 0.423, p = 0.001) and creatinine clearance (r = 0.262, p = 0.034). It was inversely correlated with cyclosporine A (CsA) level (r = −0.499, p = 0.035). Conclusion: RTA is a common complication after kidney transplantation. It is related with low creatinine clearance, low hemoglobin level, and high CsA level. Particularly, the value of creatinine clearance is lower and the possibility of RTA is higher.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 49%

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Renal tubular acidosis in renal transplantation recipients

et al. 2010

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“…Renal pathologic examination is not available for the cases of RTA associated with the other hyperglobulinémie entities listed in table V, but most of these diseases can cause renal tubular injury and/or an interstitial nephritis. In addition, the immunologically me diated interstitial infiltrate which occurs with the trans plant rejection process can be accompanied by RTA [30].…”

Section: Dr Tannenmentioning

confidence: 99%

Metabolic Acidosis in a Young Woman

et al. 1984

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“…However, hypophosphatemia, due to the appear ance of a renal tubular phosphate handling disfunction [209,210] or treatment with corticosteroid or phosphate binding antacids, has been considered a cause of persistent osteomalacia aftersuccessful transplantation [211], Amyloid bone lesions, related to [T-microglobulin accumulation, improve clinically but not radiologically [212]. Moreover, any degree of possible renal insufficiency an d /o r of renal tubular acidosis [213] occurring after transplantation, is a potential pathogenic factor of metabolic bone disease. Fi nally, steroid therapy per se [214] or especially if superim posed on hyperosteoclasia [203] has been confirmed, also recently [215], as a main pathogenic factor of osteopenia.…”

Section: Assessment Of Bone Turnover Following Renal Transplantationmentioning

confidence: 99%