Renal Transplantation in Systemic Lupus erythematosus

Yakub, Nabil; Freeman, Richard B.; Pabico, Rufino C.

doi:10.1159/000182053

Cited by 40 publications

(7 citation statements)

References 8 publications

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“…Yet so far very few cases of recurrent lupus nephritis in a renal allograft have been reported [1,32]. In these cases, while the renal histo pathologic findings were remarkably parallel to those seen during primary disease, the theoretical possibility of two different types of GN, as in our case, still remains.…”

Section: Discussionsupporting

confidence: 53%

Pre- and Posttransplant Glomerulonephritis in a Case of Sarcoidosis

Beaufils

Gompel

Gübler

et al. 1983

Nephron

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A 39-year-old woman with documented sarcoidosis and membranous glomerulonephritis (GN) with renal failure received a kidney from her identical twin. A few months after transplantation a proliferative GN appeared with hematuria, proteinuria and progressive renal failure over 2 years. Indeed the occurrence of GN in patients with sarcoidosis raises the question of whether the relationship between these two conditions is causal or fortuitous. This report suggests that GN is secondary to sarcoidosis.

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Section: Discussionsupporting

confidence: 53%

Pre- and Posttransplant Glomerulonephritis in a Case of Sarcoidosis

Beaufils

Gompel

Gübler

et al. 1983

Nephron

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“…In the 2 patients with renal function impairment, renal biopsy showed chronic rejec tion and nephroangiosclerosis. The recurrence of lupus nephritis in renal allografts is uncommon, and a rela tively small number of cases has been published [3,9,10). These patients displayed the same renal histological changes in the graft as in their original kidney.…”

Section: Discussionmentioning

confidence: 99%

Kidney Transplantation in Systemic Lupus erythematosus Nephritis: A One-Center Experience

Rivera

Marcén²,

Pascual³

et al. 1990

Nephron

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Eight patients with end-stage renal disease secondary to systemic lupus erythematosus (SLE) received 8 cadaveric renal allograft. Patient and graft survival was 100 and 87%, respectively. None of them showed extrarenal manifestations of SLE or recurrence of lupus nephritis after grafting. One graft was lost because of chronic rejection. In another patient, an episode of graft function deterioration due to bad control of arterial hypertension was observed. Three patients were transplanted during their first year on hemodialysis. Two women became pregnant after successful kidney transplantation; one suffered a spontaneous abortion and the other had a successful delivery. In neither of them, was SLE observed during or after pregnancy. Morbidity was low in this series, and infections were the most frequent complication. In summary, our experience with renal transplantation in SLE patients compares, favorably with the general nodiabetic transplanted population.

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“…It was presumed that the underlying pathophysiology would result in recurrence of lupus nephritis, even though the immunosuppressive drugs given to prevent graft rejection suppress SLE disease activity (8). While recurrence of lupus nephritis in allografts has been reported in a small number of cases, concerns about recurrence and graft destruction have been largely allayed (9)(10)(11). A 1975 report citing 56 cases from 36 centers established that recipients with SLE had 1-and 2-year graft survival comparable to recipients with other causes of renal failure (12).…”

Section: Systemic Lupus Erythematosus and Renal Transplantationmentioning

confidence: 99%

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

McGrory¹,

McCloskey²,

DeHoratius

et al. 2003

American Journal of Transplantation

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This study compares pregnancy outcomes in systemic lupus erythematosus (SLE) patients post renal transplant with recipients with other primary diagnoses, utilizing data from the National Transplantation Pregnancy Registry, Philadelphia, PA. Recipients were referred from transplant centers nationwide. A retrospective analysis was performed using data from questionnaires, hospital records and telephone interviews. Outcomes of pregnancies post renal transplant secondary to lupus nephritis (SLE: n Ω 38; 60 pregnancies) were compared with the pregnancy outcomes of renal recipients with other diagnoses (non-SLE: n Ω 247; 374 pregnancies). Drug-treated hypertension during pregnancy was less common in the SLE group than in the non-SLE group (45.0% vs. 62.5%, p Ω 0.015). There were fewer cesarean sections in the SLE group (30.2 vs. 53.2%, p Ω 0.008). There was no primary or gestational diabetes in the SLE group. There were no other statistical differences in maternal conditions or pregnancy outcomes between the SLE and non-SLE groups, or in the incidence of post pregnancy graft loss. Female recipients transplanted for renal failure secondary to lupus nephritis can successfully maintain pregnancy. Outcomes are comparable to renal recipients with other diagnoses. Newborns in both groups were often premature and had low birthweight. Overall childhood health was reported to be good; there were no apparent predominant structural malformations among the children.

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Renal Transplantation in Systemic Lupus erythematosus

Cited by 40 publications

References 8 publications

Pre- and Posttransplant Glomerulonephritis in a Case of Sarcoidosis

Pre- and Posttransplant Glomerulonephritis in a Case of Sarcoidosis

Kidney Transplantation in Systemic Lupus erythematosus Nephritis: A One-Center Experience

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

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