Renal Transplantation in Identical Twins

Starzl, TE; Brittain, R. S.; Stonnington, O. G.; Coppinger, William R.; Waddell, William R.

doi:10.1001/archsurg.1963.01310100084013

Cited by 20 publications

(2 citation statements)

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“…Although kidneys were successfully transplanted in the pioneer identical twin cases despite protracted periods of warm ischemia, the maturation of clinical transplantation could not proceed without effective organ conservation. This was accomplished at first with total body hypothermia of living volunteer kidney donors [217] using methods developed by cardiac surgeons for open heart operations [218]. In the experimental laboratory, Lillehei et al [40] simply immersed the excised intestine in iced saline before its autotransplantation, a method also used by Shumway when developing experimental and clinical heart and heart-lung transplantation [45][46][47].…”

Section: Ripple Effect Organ Procurement and Preservationmentioning

confidence: 99%

History of Clinical Transplantation

Starzl

2000

World j. surg.

150

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The emergence of transplantation has seen the development of increasingly potent immunosuppressive agents, progressively better methods of tissue and organ preservation, refinements in histocompatibility matching, and numerous innovations in surgical techniques. Such efforts in combination ultimately made it possible to successfully engraft all of the organs and bone marrow cells in humans. At a more fundamental level, however, the transplantation enterprise hinged on two seminal turning points. The first was the recognition by Billingham, Brent, and Medawar in 1953 that it was possible to induce chimerism-associated neonatal tolerance deliberately. This discovery escalated over the next 15 years to the first successful bone marrow transplantations in humans in 1968. The second turning point was the demonstration during the early 1960s that canine and human organ allografts could self-induce tolerance with the aid of immunosuppression. By the end of 1962, however, it had been incorrectly concluded that turning points one and two involved different immune mechanisms. The error was not corrected until well into the 1990s. In this historical account, the vast literature that sprang up during the intervening 30 years has been summarized. Although admirably documenting empiric progress in clinical transplantation, its failure to explain organ allograft acceptance predestined organ recipients to lifetime immunosuppression and precluded fundamental changes in the treatment policies. After it was discovered in 1992 that long-surviving organ transplant recipients had persistent microchimerism, it was possible to see the mechanistic commonality of organ and bone marrow transplantation. A clarifying central principle of immunology could then be synthesized with which to guide efforts to induce tolerance systematically to human tissues and perhaps ultimately to xenografts.

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Section: Ripple Effect Organ Procurement and Preservationmentioning

confidence: 99%

History of Clinical Transplantation

Starzl

2000

World j. surg.

150

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“…El trasplante fue practicado entre los gemelos idénticos Richard (Receptor) y Ronald (Donante) Herrick. La primera serie de experiencias exitosas 5,6 en TxR puso de manifiesto dos aspectos clínicos de vital importancia para obtener buenos resultados en trasplante, a saber: 1) la similitud genética entre el donante y el receptor determina en gran medida el éxito obtenido con el trasplante y 2) la reducción en los tiempos de isquemia del injerto renal es una medida coadyuvante para el éxito terapéutico en trasplante.…”

Section: Introductionunclassified

Trasplante renal de donante vivo: “una mirada global”

Castañeda

Rebolledo

Martin

et al. 2014

Urología Colombiana

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Resumen El trasplante renal se practica desde hace más de cuatro décadas en Colombia y actualmente se posiciona como la mejor opción terapéutica para personas con enfermedad renal crónica en fase terminal. A su vez, el trasplante renal con injerto de donante vivo presenta múltiples ventajas clínicas e inmunológicas que condicionan mejores resultados funcionales y de sobrevida a largo plazo respecto a los trasplantes renales con injerto de donante cadavérico. El objetivo de esta revisión es dilucidar a la luz de las investigaciones médicas recientes el roll del trasplante renal con injerto de donante vivo como opción terapéutica para pacientes con enfermedad renal crónica terminal, exponer los resultados clínicos obtenidos en donantes de riñón a largo plazo, y abrir una breve discusión respecto a las técnicas abierta vs laparoscópica para nefrectomía en el donante. Se realizó una revisión de la literatura en las bases de datos Embase y Medline incluyendo los términos MesH: idney Failure, Chronic , idney Transplantation , Living Donors , Nephrectomy ; algunas publicaciones fueron incluidas dada su relevancia y significancia clínica.2013 Sociedad Colombiana de Urología. Publicado por Elsevier España, S.L. Todos los derechos reservados.

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Immunological mechanisms of allograft rejection

Rowlands¹

1969

Archives of Internal Medicine

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Renal Transplantation in Identical Twins

Abstract: C~I :is s11t.11 twins (level011 [I., 1111 .ill! nccc1)t.i11lc for I~o m o g r a f r i~i g .~: ' '1'1ic l)rol>lt~~ii\ encotmtcrcrl with ti?rt~ittrtl ior ~,ul)lic.:ttioti Nov. 5, I%?.

Cited by 20 publications

References 12 publications

History of Clinical Transplantation

History of Clinical Transplantation

Trasplante renal de donante vivo: “una mirada global”

Immunological mechanisms of allograft rejection

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