Renal Transplant Dysfunction due to Severe Aorto-Iliac Atherosclerosis in the Presence of Patent Renal Transplant Artery

Abstract

We report a case of progressive deterioration in renal function and decreased renal graft perfusion induced by extensive aorto-iliac atherosclerotic lesions proximal to a patent renal graft artery. Significant improvement in kidney graft function followed left axillo-femoral bypass graft surgery, which to the best of our knowledge, has never been performed previously for permanent maintenance of renal transplant perfusion.

Structural and functional characteristics of S1P receptors

“…This protective effect of FTY720-P on endothelial cells may have a particular relevance in the prevention of chronic rejection after graft transplantation. Chronic allograft vasculopathy remains a leading cause of graft failure after organ transplantation [Uretsky et al, 1992;Aranda and Hill, 2000;Tovbin et al, 2000]. Many different risk factors determine the accelerated arteriosclerosis after transplantation, both immunological and non-immunological, such as genetic factors, injury of endothelial cells after ischemia-reperfusion, viral infections, or the immunosuppressor therapy itself.…”

Renal Transplant Artery Inflow Stenosis Treated with Femorofemoral Bypass

“…9 Surgical treatment such as bypass is suggested for patients with worsening atherosclerosis of the iliac arteries leading to allograft ischemia. 10,11 In this instance, there was no significant gradient onto the left common femoral artery. If a gradient had existed, stenting the left iliac artery with balloon angioplasty may have been warranted.…”