Renal transitional cell carcinoma with bilateral ocular metastasis in a cat

Grader, Irit; Southard, Teresa; Neaderland, Marjorie H

doi:10.1177/2055116916659516

Cited by 4 publications

(8 citation statements)

References 26 publications

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“…The eyes are considered to be uncommon metastatic sites in dogs and cats 1‐6 ; however, other studies have reported cases with an ocular involvement of metastatic neoplastic diseases 5,7‐12 . Furthermore, as in humans, metastases to the eyes occur mostly via hematogenous spread, usually affecting the uveal tract 1,2,5,10,13 …”

Section: Introductionmentioning

confidence: 99%

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Bandinelli

Bianchi

Wronski

et al. 2020

Veterinary Ophthalmology

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Objective To characterize the frequency and distribution of secondary ocular neoplasms in dogs and cats identified during necropsy. Methods A retrospective analysis of necropsy records of dogs and cats was conducted, and cases with metastatic/multicentric neoplasms with an extraocular origin, involving the eyes, were selected. Results From January 2015 to January 2019, we identified a total of 233 dogs and 100 cats with metastatic disease. Of these, 11.6% (27/233) of the dogs and 13% (13/100) of the cats had ocular metastases. Lymphoma was the most common multicentric neoplasm involving the eyes of both species. In dogs, these neoplasms occurred bilaterally, predominantly in the anterior uvea, and were diffuse large B‐cell, T‐lymphoblastic, peripheral T‐cell not otherwise specified, and lymphocytic B‐cell lymphomas. In cats, feline leukemia virus (FeLV)‐associated T‐cell lymphoma was the most common. Mammary carcinoma was the second most common ocular metastatic neoplasm in bitches, with a predominantly unilateral involvement of the uveal tract. In cats, following lymphoma, pulmonary and squamous cell carcinomas were the most common multicentric/metastatic neoplasms of the eyes. Individual cases of cholangiocarcinoma, hemangiosarcoma, and chemodectoma in dogs, as well as mammary gland cribriform carcinoma, salivary gland carcinoma, and histiocytic sarcoma in cats were detected. Conclusions The eyes of dogs were mostly affected by lymphoma or mammary gland carcinoma, while those of cats mostly had lymphoma, pulmonary carcinoma, or squamous cell carcinoma as the main metastatic/multicentric neoplasm. To the best of our knowledge, this is the first study to identify intraocular metastatic cholangiocarcinoma and chemodectoma in dogs, aside from identifying salivary gland carcinoma in cats.

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Section: Introductionmentioning

confidence: 99%

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Bandinelli

Bianchi

Wronski

et al. 2020

Veterinary Ophthalmology

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“… 27 , 28 The traditional urothelial IHC markers CK7, CK20 and uroplakin-III did not meet the canine-derived threshold for positivity, arguing against a neoplasm of urothelial origin, but a different threshold may be warranted in cats. 29 – 32 Since these markers were negative, we pursued KIM-1 IHC. Although this marker has not previously been used to investigate tumor differentiation in feline samples, KIM-1 is expressed in human, mouse and feline proximal convoluted tubules that have been injured, dedifferentiated or undergone replication.…”

Section: Discussionmentioning

confidence: 99%

Unilateral primary carcinoma of the kidney with central nervous system invasion and vertebral lysis in a cat

Ludwig

Husník

Ratsep

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

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Case summary A young adult female spayed domestic shorthair cat presented for acute hindlimb weakness and anorexia with a 1-month history of lethargy, hyporexia and weight loss. A mass was palpable in the caudolateral abdomen and the left hindlimb was diffusely edematous. Abdominal ultrasound showed hydronephrosis of the left kidney with suspected hydroureter and heterogeneous tissue in the dorsal abdomen. CT evaluation confirmed a mass extending from the left kidney through the lumbar musculature with hydronephrosis, aortic attenuation, caudal vena caval thrombosis and lysis of vertebrae 4 and 5. Fine-needle aspiration of the mass suggested squamous cell carcinoma. Owing to clinical deterioration, euthanasia was elected. At necropsy, the left kidney was firmly adhered to the lumbar region with tissue that obliterated the musculature and surrounded the aorta and vena cava. There was hydronephrosis of the left kidney. Histopathologic evaluation of the mass revealed islands of neoplastic epithelial cells separated by fibrous connective tissue and areas of gradual keratinization with rare squamous metaplasia. The histologic diagnosis was invasive carcinoma with desmoplasia and vascular invasion. Relevance and novel information Primary carcinomas of the kidney in cats are rare and this report documents a progression of disease not previously reported in cats. This is the second reported case of a primary carcinoma of renal origin with features of squamous cell carcinoma in a cat, and the first with lumbar and vascular invasion. This is also the first use of kidney injury molecule-1 to help investigate tumor differentiation in cats.

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“…1,2 Of primary feline renal tumours, 60%-77% are epithelial, with renal cell carcinoma (RCC) predominating; other epithelial tumours, including transitional cell carcinoma, squamous cell carcinoma, renal adenoma, and renal oncocytoma are infrequently reported. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Additionally, primary renal hemangiosarcoma, leiomyosarcoma, myxoma, myxosarcoma, paraganglioma, and nephroblastoma have been documented. 2,3,[17][18][19][20][21] Larger studies evaluating feline RC are lacking.…”

Section: Introductionmentioning

confidence: 99%

“…3 Additional RTCC case reports include: a cat with a perinephric cyst; two cats with a history of chronic kidney disease (CKD); and a young cat with ocular, pulmonary, and skeletal metastases. [11][12][13] A solitary case report described a young cat with RSCC and abdominal carcinomatosis. 14 Presently, there is limited information regarding the biologic behaviour and postoperative outcomes in feline RC.…”

Section: Introductionmentioning

confidence: 99%

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Clinical outcomes in cats with renal carcinoma undergoing nephrectomy: A retrospective study

Kenny

Cook

Lenz

et al. 2023

Vet Comparative Oncology

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Renal carcinomas (RC) are uncommonly encountered in feline medicine. Limited information regarding clinical presentation and postoperative outcomes is available. The purpose of this multi‐institutional, retrospective study was to describe the presenting features and clinical outcomes of cats with RC undergoing nephrectomy. Thirty‐six client‐owned cats were included. Medical records from participating institutions were searched to identify cats that had a histopathologic diagnosis of RC and underwent nephrectomy from January 2001 to October 2021. The most common presenting complaints were weight loss (36.1%) and hyporexia (30.6%). Based on preoperative imaging and intraoperative findings, eight cats had suspected metastasis at the time of surgery (22.2%). Twenty‐eight cats survived to discharge (77.8%). Median progression free interval (PFI) could not be determined, as only six cats developed suspected recurrence (16.7%) and seven cats developed suspected metastasis (19.4%). The all‐cause median survival time (MST) was 203 days (95% confidence interval [CI]: 84, 1379 days). When cases that died prior to discharge were excluded, MST increased to 1217 days (95% CI: 127, 1641 days). One‐year, two‐year, and three‐year survival rates were all 40.4%. Neither renal tumour histologic subtype nor the presence of preoperative azotemia, anaemia, erythrocytosis, haematuria, or suspected metastasis at diagnosis were found to influence survival. For cats surviving to discharge, prolonged survival times were possible. Further studies are necessary to elucidate other potential prognostic factors, the utility of postoperative adjuvant treatment, and to identify cats at‐risk of mortality in the perioperative period.

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Renal transitional cell carcinoma with bilateral ocular metastasis in a cat

Cited by 4 publications

References 26 publications

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Unilateral primary carcinoma of the kidney with central nervous system invasion and vertebral lysis in a cat

Clinical outcomes in cats with renal carcinoma undergoing nephrectomy: A retrospective study

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