Renal tolerance of cisplatin in patients more than 80 years old.

Thyss, A.; Saudes, Laurence; Otto, J.; Creisson, Anne; Gaspard, M; Dassonville, O.; Schneider, M

doi:10.1200/jco.1994.12.10.2121

Cited by 62 publications

(26 citation statements)

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“…The toxicity of antineoplastic agents in older patients may be different from that in younger individuals because of the decreased hepatic or renal functions that are the main mechanisms of elimination [15][16][17][18] . Although the age-related decrement in GFR is a fact, no convincing evidence exists that the incidence and severity of platinum nephrotoxicity increase with the age of the patient [19,20] . Similarly, we adjusted cisplatin dosage according to creatinine clearance for only 2 patients and observed only one incidence of chemotherapy-induced nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Does Age Affect the Prognosis of Patients with Testicular Germ Cell Tumor?

et al. 2007

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Introduction: In this study, the effect of age on the prognosis of testicular germ cell tumors in patients over 40 was investigated. Materials and Methods: Ninety-three patients with testicular germ cell tumor who were 40 years old and over were identified in our germ cell tumor database. Patients were grouped according to their age with those between 40 and 44, 45 and 49 and 50 and over constituting groups I, II and III, respectively. Results: Only 15% of the patients of group III had localized disease (p = 0.002). Group III patients had a significantly lower response rate to initial chemotherapy and a higher disease progression rate during therapy (complete response rate: 33.3%, progression rate: 44.4%, p = 0.035). The multivariate analysis revealed that advanced stage was the only independent prognostic factor for survival (p = 0.0011). Conclusion: Testicular germ cell tumor patients over 50 years old presented with a more advanced stage and had higher disease progression and disease mortality rates.

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Section: Discussionmentioning

confidence: 99%

Does Age Affect the Prognosis of Patients with Testicular Germ Cell Tumor?

et al. 2007

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“…Furthermore, a marked discrepancy between the CG and the MDRD formulae has been observed in a large population of over 65 years of age (20) and these formulae have been found to lack a consistent proportion of patients with renal failure within a population of octogenarian inpatients (21). Studies estimating renal function in solid cancer patients have previously been published (22)(23)(24)(25). However, the number of the cancer patients aged 80 years or older evaluated for renal function was limited (24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Studies estimating renal function in solid cancer patients have previously been published (22)(23)(24)(25). However, the number of the cancer patients aged 80 years or older evaluated for renal function was limited (24,25). Therefore, additional studies focusing specifically on renal function in very elderly lung cancer patients are required.…”

Section: Discussionmentioning

confidence: 99%

Age-dependent decline in renal function in patients with lung cancer

et al. 2012

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Abstract. The aim of this study was to clarify the effect of aging on renal function. Serum creatinine (SCr), blood urea nitrogen (BUN) and 24-h creatinine clearance (measuredCrCl) were examined in lung cancer patients and the measured-CrCl were compared with CrCl estimates by employing two commonly used equations. In total, 787 lung cancer patients who were diagnosed between 2001 and 2010 were retrospectively analyzed. SCr and urine creatinine, BUN and measured-CrCl were evaluated prior to treatment. The Cockcroft-Gault (CG) and modification of diet in renal disease (MDRD) formulae were also used to estimate CrCl. SCr, BUN and measured-CrCl showed a significant decline in the elderly. In the 787 lung cancer patients, a significant correlation coefficient was found between measured-CrCl and age. However, in patients aged 80 years or older, no significant correlation coefficient was found between measured-CrCl and age. In the comparison between the measured CrCl and the CrCls estimated by the two formulae, the CG-CrCl levels were lower than those of the measured-CrCl, whereas the MDRDCrCl levels were higher. Age is a crucial factor influencing renal function in patients with lung cancer. Particularly in the elderly, a decline in CrCl and greater individual variability in CrCl, as well as discrepancies in measured-CrCl and estimated CrCls are significant factors.

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“…Cisplatin is one of the most effective and widely used anticancer drugs, and it is considered to have acceptable toxicity for old patients (35,38). No increased toxicity was observed in the elderly when the cisplatin dose was increased (52,58), and it was suggested that its toxicity was inversely dependent on the dose administered. We found that a low dose of cisplatin causes necrosis in old cells whereas a high dose induces apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

Seluanov

Gorbunova

Falcovitz

et al. 2001

Molecular and Cellular Biology

144

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The cellular function of p53 is complex. It is well known that p53 plays a key role in cellular response to DNA damage. Moreover, p53 was implicated in cellular senescence, and it was demonstrated that p53 undergoes modification in senescent cells. However, it is not known how these modifications affect the ability of senescent cells to respond to DNA damage. To address this question, we studied the responses of cultured young and old normal diploid human fibroblasts to a variety of genotoxic stresses. Young fibroblasts were able to undergo p53-dependent and p53-independent apoptosis. In contrast, senescent fibroblasts were unable to undergo p53-dependent apoptosis, whereas p53-independent apoptosis was only slightly reduced. Interestingly, instead of undergoing p53-dependent apoptosis, senescent fibroblasts underwent necrosis. Furthermore, we found that old cells were unable to stabilize p53 in response to DNA damage. Exogenous expression or stabilization of p53 with proteasome inhibitors in old fibroblasts restored their ability to undergo apoptosis. Our results suggest that stabilization of p53 in response to DNA damage is impaired in old fibroblasts, resulting in induction of necrosis. The role of this phenomenon in normal aging and anticancer therapy is discussed.

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Renal tolerance of cisplatin in patients more than 80 years old.

Abstract: CDDP at moderate doses can reasonably be administered to patients older than 80 years who may benefit from antineoplastic chemotherapy.

Cited by 62 publications

References 0 publications

Does Age Affect the Prognosis of Patients with Testicular Germ Cell Tumor?

Does Age Affect the Prognosis of Patients with Testicular Germ Cell Tumor?

Age-dependent decline in renal function in patients with lung cancer

Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

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