“…97,98,100 -102 BBB permeability studies of glycopeptides have indicated up to a three-fold increase in the rate of brain delivery, compared to the unglycosylated parent peptides. 97,101,102 Evidence also suggests that the type of glycosylation (i.e., mono-, di-, tri-glycosylation) can alter tissue distribution patterns, [103][104][105] BBB permeability, 102 and peptide/receptor interactions. 106,107 Peptides investigated to date include recombinant human erythropoietin, 108 leptin, 108 dermorphins 98 and metenkephalin analogs.…”