Renal Synovial Sarcoma in a Young Pregnant Lady: A Case Report and Clinico-Pathological Profile

Pathrose, Gregory; John, Nirmal Thampi; Hariharan, Pradeep

doi:10.7860/jcdr/2017/25733.10245

Cited by 6 publications

(13 citation statements)

References 8 publications

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“…The different subtypes of bone and soft tissue tumors that have been reported in association with pregnancy include: osteosarcoma, 4 5 6 7 8 chondrosarcoma, 4 6 9 liposarcoma, 10 11 12 rhabdomyosarcoma, 13 14 15 malignant fibrous histiocytoma, 16 17 18 fibrosarcoma, 19 20 Ewing's sarcoma, 21 22 giant cell tumors, 6 23 and synovial sarcoma. 24 25 26 27…”

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confidence: 99%

Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors

Figueiró-Filho

Al-Sum

Parrish

et al. 2018

AJP Rep

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Objective This study was aimed to describe perinatal outcome of a cohort of pregnant patients with bone and soft tissue tumors and to compare the current series with our group's previously reported experience. Methods Pregnant women diagnosed before and during pregnancy were identified, retrospectively, for the years 2004 to 2014. Relevant maternal and neonatal data were collected. Results Forty-eight patients were identified. Ten cases were diagnosed during pregnancy. Pelvis, abdomen, and extremities were the most common tumor locations. Osteosarcoma, liposarcoma, and Ewing's sarcoma were the most common histological types and comprise more than 50% of the cases. Metastases occurred in nine cases. Most of the cases (60%) were treated surgically during pregnancy and delivery occurred at term. Chemotherapy was delayed until after delivery. There were no perinatal or infant deaths. Patients presented with advanced maternal disease in 18% in previous report (1983–2003) versus 40% in present report (2004–2014). Metastases were present in 40% and maternal death rate was approximately 20% in both cohorts. Conclusion Pregnant women with bone and soft tissue tumors are candidates for standard surgical management during pregnancy. Other treatments, such as chemotherapy and radiotherapy must be evaluated for each woman on a case-by-case basis. Iatrogenic prematurity was common in our findings.

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confidence: 99%

Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors

Figueiró-Filho

Al-Sum

Parrish

et al. 2018

AJP Rep

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“…Our literature search revealed that only 12 cases of synovial sarcomas during pregnancy have been reported since 2006. Of the 12 cases of synovial sarcomas during pregnancy that have been reported since 2006, five were pulmonary,3–7 three were renal,8–10 two involved the head and neck,11 12 one involved the abdominal wall,13 and the last, like our patient, involved the upper left thigh 14. The three patients who passed away during the course of follow-up all had the diagnosis of pulmonary synovial sarcomas.…”

Section: Discussionmentioning

confidence: 49%

Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Akhanoba

Zill‐E‐Huma²,

Pollock

et al. 2019

BMJ Case Rep

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We present a first case of synovial sarcoma in an HIV-positive pregnant woman. This 28-year-old woman was diagnosed with synovial sarcoma, a high-grade malignant soft tissue sarcoma, involving her left thigh during the first trimester of her pregnancy. She underwent surgical treatment in the form of hip disarticulation at 30 weeks’ gestation. She was subsequently delivered by emergency caesarean section (CS) at 34 weeks’ gestation when she presented with wound sepsis and a scan revealed static growth in a small for gestational age fetus. Prompt diagnosis and treatment of this aggressive tumour is important and should involve a multidisciplinary approach, with a balanced consideration of the maternal and fetal outcomes.

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“…Studies by Mishra et al have shown that TLE1 is more specific and sensitive to synovial sarcomas than any immunohistochemical factor[11,12]. Molecular biology is also providing further confirmation that t(X;18) translocation can lead to syt-ssx fusion, and SYT rearrangement has become the gold standard for PRSS diagnosis[4]. A recent study has revealed a significant correlation between Pax-8 and t(X;18) translocations[13].…”

Section: Discussionmentioning

confidence: 99%

“…This case is consistent with the previously reported findings. The prognostic significance of syt-ssx fusion in synovial sarcoma has not been unified, but it has been shown to be an important prognostic indicator[4]. Because of the limited number of case reports, no guidelines for PRSS treatment have been established, but radical surgical resection is the preferred treatment.…”

Section: Discussionmentioning

confidence: 99%

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Primary renal synovial sarcoma: A case report

Cai¹,

Cao²,

Wang³

et al. 2019

WJCC

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BACKGROUNDSynovial sarcoma, a rare mesenchymal tumor type with unclear histological origin and direction of differentiation, accounts for 6%–10% of soft tissue tumors. It is mainly located near the joints and tendons of the limbs, and occurs primarily in children or young adults. Primary renal synovial sarcoma (PRSS) is very rare, accounting for approximately 1% of synovial sarcomas. It is a spindle cell tumor type affecting mesenchymal tissue, and has morphological, genetic, and clinical characteristics, and a certain degree of epithelial differentiation. It is highly malignant and has the fourth highest incidence among soft tissue sarcomas. Here, we report a case of PRSS and share some valuable information about the disease.CASE SUMMARYA 54-year-old male patient was admitted to the hospital for a space-occupying lesion in the right kidney for 2 d upon ultrasound examination. The patient had no cold or fever; no frequency, urgency or pain of urination; and no other discomfort. The results of a hemogram, blood biochemistry, and tumor markers were in the normal range. The patient was examined by computed tomography (CT), which indicated the presence of a soft tissue density shadow with a diameter of approximately 6.8 cm in the right renal pelvis area, showing uneven enhancement. Ultrasound indicated a cystic solid mass of approximately 6.8 cm × 6.5 cm in the right kidney, with an unclear boundary and irregular shape. Meanwhile, color Doppler flow imaging showed dotted blood flow signals in the periphery and interior. Contrast-enhanced ultrasound (CEUS) showed "slow in and fast out" hyperenhancement of the right renal mass after contrast agent injection. The postoperative pathological diagnosis was (right kidney) synovial sarcoma. Despite postoperative adjuvant chemotherapy, tumor recurrence was detected two years later.CONCLUSIONPRSS is a rare malignant tumor. To date, no characteristic imaging findings have been observed. The diagnosis is confirmed primarily through postoperative pathological immunohistochemistry and SS18 (SYT) gene detection. In this case, CEUS was used preoperatively. We found that PRSS has the characteristic of "slow in and fast out" hyperenhancement, and its particular characteristics have diagnostic value. Postoperative adjuvant chemotherapy is not very effective.

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Renal Synovial Sarcoma in a Young Pregnant Lady: A Case Report and Clinico-Pathological Profile

Cited by 6 publications

References 8 publications

Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors

Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors

Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Primary renal synovial sarcoma: A case report

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