Renal sympathoinhibition induced by hypernatremia: Involvement of A1 noradrenergic neurons

Pedrino, Gustavo Rodrigues; Rosa, Daniel Alves; Korim, Willian S.; Cravo, Sérgio L.

doi:10.1016/j.autneu.2008.06.006

Cited by 28 publications

(48 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase of renal blood flow and vascular conduction induced by intravenous hypertonic saline infusion was abolished in rats treated with anti-DβH-saporin (17). Furthermore, lesion of A1 noradrenergic neurons prevented the renal sympathoinhibition induced by hypernatremia (4). Additionally, we have demonstrated that these noradrenergic cells were part of an inhibitory circuit involved in the control of NaCl intake induced by ANG II-dependent mechanisms (37).…”

Section: The Caudal Ventrolateral Medullamentioning

confidence: 65%

“…Now it is widely accepted that catecholaminergic A1 cells in the CVLM do not project to the RVLM, and that their main projections are to diencephalic nuclei involved in the control of water and salt balance (4,(12)(13)(14)(15)17,18).…”

Section: The Caudal Ventrolateral Medullamentioning

confidence: 99%

“…We have recently demonstrated that A1 noradrenergic neurons are involved in the autonomic and cardiovascular responses induced by increases in plasma sodium concentration (4,17). In those studies, we used anti-dopamine-β-hydroxide-saporin, an immunotoxin that selectively kills dopamine-β-hydroxide (DβH)-containing neurons.…”

Section: The Caudal Ventrolateral Medullamentioning

confidence: 99%

“…An increase in plasma sodium concentration stimulates the ingestion of water and the release of vasoactive peptides such as vasopressin, atrial natriuretic peptide (ANP) (2) and oxytocin (3), increases lumbar sympathetic activity and reduces renal and splanchnic nerve discharge (4,5), and causes a pattern of cardiovascular adjustments characterized by transient hypertension and marked and sustained increases in renal blood flow and vascular conductance (5)(6)(7).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

Cravo

Lopes

Pedrino

2011

Braz J Med Biol Res

View full text Add to dashboard Cite

Water deprivation and hypernatremia are major challenges for water and sodium homeostasis. Cellular integrity requires maintenance of water and sodium concentration within narrow limits. This regulation is obtained through engagement of multiple mechanisms and neural pathways that regulate the volume and composition of the extracellular fluid. The purpose of this short review is to summarize the literature on central neural mechanisms underlying cardiovascular, hormonal and autonomic responses to circulating volume changes, and some of the findings obtained in the last 12 years by our laboratory. We review data on neural pathways that start with afferents in the carotid body that project to medullary relays in the nucleus tractus solitarii and caudal ventrolateral medulla, which in turn project to the median preoptic nucleus in the forebrain. We also review data suggesting that noradrenergic A1 cells in the caudal ventrolateral medulla represent an essential link in neural pathways controlling extracellular fluid volume and renal sodium excretion. Finally, recent data from our laboratory suggest that these structures may also be involved in the beneficial effects of intravenous infusion of hypertonic saline on recovery from hemorrhagic shock.

show abstract

Section: The Caudal Ventrolateral Medullamentioning

confidence: 65%

Section: The Caudal Ventrolateral Medullamentioning

confidence: 99%

Section: The Caudal Ventrolateral Medullamentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

Cravo

Lopes

Pedrino

2011

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Initially it was thought that A1 neurons were part of the CVLM sympathoinhibitory group (Granata et al 1986), but later it became clear that these cells were GABAergic and located medially to the A1 neurons. Now it is well accepted that A1 neurons are central elements in regulating the volume and composition of the extracellular compartment (Pedrino et al 2008, Howe et al 2004, Buller et al 1999, Hochstenbach and Ciriello 1995, Smith et al 1995, Head et al 1987.…”

Section: The Caudal Ventrolateral Medulla (Cvlm)mentioning

confidence: 99%

Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

Cravo

Campos

Colombari

et al. 2009

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. Our current understanding of this circuitry derives mainly from the studies of Pedro Guertzenstein, a former student who became Professor of Physiology at UNIFESP later, and his colleagues. In this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions.

show abstract

Renal Nerves and Long‐Term Control of Arterial Pressure

Osborn

Foss

2017

Comprehensive Physiology

View full text Add to dashboard Cite

The objective of this review is to provide an in-depth evaluation of how renal nerves regulate renal and cardiovascular function with a focus on long-term control of arterial pressure. We begin by reviewing the anatomy of renal nerves and then briefly discuss how the activity of renal nerves affects renal function. Current methods for measurement and quantification of efferent renal-nerve activity (ERNA) in animals and humans are discussed. Acute regulation of ERNA by classical neural reflexes as well and hormonal inputs to the brain is reviewed. The role of renal nerves in long-term control of arterial pressure in normotensive and hypertensive animals (and humans) is then reviewed with a focus on studies utilizing continuous long-term monitoring of arterial pressure. This includes a review of the effect of renal-nerve ablation on long-term control of arterial pressure in experimental animals as well as humans with drug-resistant hypertension. The extent to which changes in arterial pressure are due to ablation of renal afferent or efferent nerves are reviewed. We conclude by discussing the importance of renal nerves, relative to sympathetic activity to other vascular beds, in long-term control of arterial pressure and hypertension and propose directions for future research in this field. © 2017 American Physiological Society. Compr Physiol 7:263-320, 2017.

show abstract

Renal sympathoinhibition induced by hypernatremia: Involvement of A1 noradrenergic neurons

Cited by 28 publications

References 34 publications

Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

Renal Nerves and Long‐Term Control of Arterial Pressure

Contact Info

Product

Resources

About