Renal Structural Characteristics as Indexes of Renal Adaptation for Water Conservation in the Genus Sylvilagus

Heisinger, J. F.; Breitenbach, Robert P.

doi:10.1086/physzool.42.2.30158470

Cited by 66 publications

(24 citation statements)

References 10 publications

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“…This result is consistent with the finding of convergent trends in kidney structure, including a thick medulla relative to kidney size, that have been observed in a variety of lineages of small mammals from diverse desert habitats (e.g., rabbits [Heisinger and Breitenbach 1969], hedgehogs [Yaakobi and Shkolnik 1974], insectivorous bats [Geluso 1978], and heteromyid rodents [MacMillen and Hinds 1983]). However, as noted in the previous paragraph, maximum loop length alone does not determine variation in urine concentrating ability.…”

Section: Kidney Mass In Relation To Body Mass and Habitatsupporting

confidence: 90%

“…Following Schmidt-Nielsen and O'Dell's (1961) seminal study, similar interspecific relationships have been shown in various groups of mammals (e.g., marsupials ; Sylvilagus rabbits [Heisinger and Breitenbach 1969]; cricetid rodents [Heisinger et al 1973]; dasypodids of the Argentine desert, Chaetophratus vellerous and Dasypus novemcintus ]; sciurid rodents [Blake 1977]; bats [Geluso 1978]). These studies also demonstrate a general trend for species that inhabit arid and semiarid environments to have high abilities to concentrate urine and also high RMT (see also Schmidt-Nielsen 1964;Lee 1967, 1969;Purohit 1974a;Borut and Shkolnik 1974).…”

Section: Introductionsupporting

confidence: 52%

“…Length and breadth of kidneys were measured with a vernier ‫1.0ע(‬ mm) and sagittal halfsectioned . Total width and the medullary thickness of the kidney were measured in sagittal slices from the cortex-medullar tips to the extreme of the papilla (Heisinger and Breitenbach 1969;Blake 1977) under a Wild M3 microscope. Midsagittal cuts were made to maximize the area of visualization of the medulla.…”

Section: Data Collectionmentioning

confidence: 99%

“…In addition to RMT, several other morphometric indices have been proposed to estimate renal performance (Heisinger and Breitenbach 1969;Schmid 1972;Brownfield and Wunder 1976). In all cases, higher indices are typical of small desert mammals.…”

Section: Introductionmentioning

confidence: 99%

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Kidney Mass and Relative Medullary Thickness of Rodents in Relation to Habitat, Body Size, and Phylogeny

Alkahtani

Zuleta²,

Caviedes‐Vidal³

et al. 2004

Physiological and Biochemical Zoology

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We tested the hypotheses that relative medullary thickness (RMT) and kidney mass are positively related to habitat aridity in rodents, after controlling for correlations with body mass. Body mass, mass-corrected kidney mass, mass-corrected RMT, mass-corrected maximum urine concentration, and habitat (scored on a semiquantitative scale of 1-4 to indicate increasing aridity) all showed statistically significant phylogenetic signal. Body mass varied significantly among habitats, with the main difference being that aquatic species are larger than those from other habitats.

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Section: Kidney Mass In Relation To Body Mass and Habitatsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 52%

Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Kidney Mass and Relative Medullary Thickness of Rodents in Relation to Habitat, Body Size, and Phylogeny

Alkahtani

Zuleta²,

Caviedes‐Vidal³

et al. 2004

Physiological and Biochemical Zoology

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“…The length and breadth of sagittal half-sectioned kidneys were measured using a Vernier caliper (0.1 mm) (Cortes et al, 1990). Using a Wild M3 microscope, the total width and the medullary thickness of the kidneys were measured in sagittal slices taken from the cortex-medullary tips to the extreme end of the papilla (Heisinger and Breitenbach, 1969;Blake, 1977). Midsagittal cuts were made to maximize the medullary area visualized.…”

Section: Renal Morphologymentioning

confidence: 99%

Early life experience drives short-term acclimation of metabolic and osmoregulatory traits in the leaf-eared mouse

Cavieres

Nuñez-Villegas

Bozinovic

et al. 2017

Journal of Experimental Biology

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We studied the putative effect of early life experience on the physiological flexibility of metabolic and osmoregulatory traits in the leaf-eared mouse, Phyllotis darwini, an altricial rodent inhabiting seasonal Mediterranean environments. Adult individuals were collected in central Chile and maintained in breeding pairs. Pups were isolated after weaning and acclimated to different temperatures (cold or warm) and water availability (unrestricted and restricted) until adulthood. Subsequently, individuals were re-acclimated to the opposite treatment. Rodents reared in the warm and subjected to water restriction had lower basal metabolic rate (BMR), total evaporative water loss (TEWL) and body mass (M b ) compared with those developing in the cold treatment; nevertheless, individuals subjected to warm temperatures had greater relative medullary thickness (RMT) and urine concentrating ability (UCA). Cold-reared rodents re-acclimated to warm conditions exhibited physiological flexibility of metabolic traits; however, their osmoregulatory attributes did not vary. Conversely, warm-reared rodents re-acclimated to cold had reduced RMT and UCA, but the metabolic traits of these individuals did not change. These results suggest a trade-off between metabolic performance and renal capabilities that might hinder physiological acclimation. Our results support the hypothesis of ontogenetic dependence of short-term acclimation in osmoregulatory and metabolic traits in P. darwini.

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Renal adaptation in relation to insectivorous feeding habit in the greater mouse‐eared bat, Myotis myotis (Chiroptera: Vespertilionidae)

Paksuz

2022

The Anatomical Record

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We examined the histological structure of the kidneys of Myotis myotis to better understand their structural adaptations to dietary habits. M. myotis is an insectivorous bat species that belongs to the family Vespertilionidae. The kidneys of M. myotis are unilobular, bean‐shaped, and surrounded by a renal capsule. The two parts are distinguished by a thin cortex and a thicker medulla. Renal corpuscles consist of the glomerulus and Bowman's capsule. The proximal tubule consists of cubic cells with a well‐developed brush border, whereas the distal tubule is lined with a simple cubic epithelium without a brush border. The Henle's loop, located in the medullary region, was composed of flat cells. The microvilli of proximal tubule epithelial cells and basal lamina of proximal and distal tubule epithelial cells were periodic acid Schiff (PAS)‐positive. The PAS‐positive reaction of the microvilli of proximal tubular epithelial cells and basal lamina of proximal and distal tubule epithelial cells is due to the presence of glycogen, which may be used as an energy substrate during absorption. The presence of acidic glycoconjugates in the papilla was demonstrated by Alcian blue (pH 2.5)‐PAS staining. According to the result of silver impregnation staining, it was determined that reticular fibers form a dense fibrillary network in the kidney parenchymal tissue. Reticular fibers are responsible for demarcating and supporting the borders of cells by forming a thin network of fibrils beneath the basal lamina of the cells. Structural features in the kidney, such as a thin cortex and thicker medulla, long conical papilla, and division of the thick medulla into inner and outer regions, of M. myotis may be an adaptation to produce concentrated urine, thereby reducing water loss associated with insectivorous feeding habits.

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Renal Structural Characteristics as Indexes of Renal Adaptation for Water Conservation in the Genus Sylvilagus

Cited by 66 publications

References 10 publications

Kidney Mass and Relative Medullary Thickness of Rodents in Relation to Habitat, Body Size, and Phylogeny

Kidney Mass and Relative Medullary Thickness of Rodents in Relation to Habitat, Body Size, and Phylogeny

Early life experience drives short-term acclimation of metabolic and osmoregulatory traits in the leaf-eared mouse

Renal adaptation in relation to insectivorous feeding habit in the greater mouse‐eared bat, Myotis myotis (Chiroptera: Vespertilionidae)

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