Renal Stone Risk in a Simulated Microgravity Environment: Impact of Treadmill Exercise With Lower Body Negative Pressure

Monga, Manoj; Macias, Brandon R.; Groppo, Eli R.; Kostelec, Monica; Hargens, Alan R.

doi:10.1016/s0022-5347(06)00572-6

Cited by 26 publications

(17 citation statements)

References 12 publications

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“…Other means of reducing bone resorption, and renal stone risk, have also been tested, including pharmacologic agents and exercise protocols (Monga et al. ; Leblanc et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…Bone demineralization during spaceflight and bed rest increases urinary calcium, which alters urine chemistry to favor renal stone formation (Whitson et al 1993(Whitson et al , 1997(Whitson et al , 1999Monga et al 2006;Okada et al 2008). Renal stone risk, typically assessed by calculating relative urine supersaturation, is generally low during bed rest because subjects are encouraged to consume large amounts of fluid, specifically to minimize this risk.…”

Section: Introductionmentioning

confidence: 99%

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Sex‐specific responses of bone metabolism and renal stone risk during bed rest

Morgan

Heer

Hargens

et al. 2014

Physiological Reports

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The purpose of this study was to directly assess sex differences in bone loss, bone biochemistry, and renal stone risk in bed rest. Bed rest simulates some spaceflight effects on human physiology and can be used to address the potential existence of sex‐specific effects on bone metabolism and renal stone risk in space. We combined data from the control subjects in five head‐down‐tilt bed rest studies (combined n = 50 men, 24 women) of differing durations (14–90 days). All subjects were healthy volunteers. Mean age was 35 ± 9 years for women and 33 ± 8 years for men. The main outcome measures were bone density and biochemistry, and renal stone risk chemistry. Before bed rest began, men had higher bone mineral density and content (P < 0.001), and excreted more biomarkers of bone resorption and calcium per day than did women (P < 0.05). These differences remained during bed rest. A number of urine chemistry analytes increased (e.g., calcium) or decreased (e.g., sodium, citrate, and urine volume) significantly for men and women during bed rest. These changes may predispose men to higher stone risk. Men and women do not have substantially different responses to the skeletal unloading of bed rest.

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“…Other means of reducing bone resorption, and renal stone risk, have also been tested, including pharmacologic agents and exercise protocols (Monga et al. ; Leblanc et al. ).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex‐specific responses of bone metabolism and renal stone risk during bed rest

Morgan

Heer

Hargens

et al. 2014

Physiological Reports

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“…This increased risk has been documented during both short- and long-duration space missions [103,104,105], as well as in bed rest [106,107,108,109,110]. Given that the occurrence of a kidney stone on orbit would likely result in the medical evacuation of the affected crewmember (and likely end the mission for all crewmembers, given the nature of spacecraft), the likelihood of a kidney stone occurring has warranted a fair amount of attention.…”

Section: Urinary Calcium and Renal Stone Riskmentioning

confidence: 99%

Space Flight Calcium: Implications for Astronaut Health, Spacecraft Operations, and Earth

et al. 2012

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The space flight environment is known to induce bone loss and, subsequently, calcium loss. The longer the mission, generally the more bone and calcium are lost. This review provides a history of bone and calcium studies related to space flight and highlights issues related to calcium excretion that the space program must consider so that urine can be recycled. It also discusses a novel technique using natural stable isotopes of calcium that will be helpful in the future to determine calcium and bone balance during space flight.

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“…Prolonged exposure to microgravity during spaceflight increases the risk of renal stone formation. Lower body negative pressure chamber treadmill, alkali therapy, and aggressive hydration are recommended countermeasures to decrease urinary supersaturation [33].…”

Section: Chronic Systemic Mild Hypohydration or Dehydration Urolithiasismentioning

confidence: 99%

Hydration and Disease

Manz

2007

Journal of the American College of Nutrition

102

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Many diseases have multifactorial origins. There is increasing evidence that mild dehydration plays a role in the development of various morbidities. In this review, effects of hydration status on acute and chronic diseases are depicted (excluding the acute effects of mild dehydration on exercise performance, wellness, cognitive function, and mental performance) and categorized according to four categories of evidence (I-IV). Avoidance of a high fluid intake as a precautionary measure may be indicated in patients with cardiovascular disorders, pronounced chronic renal failure (III), hypoalbuminemia, endocrinopathies, or in tumor patients with cisplatin therapy (IIb) and menace of water intoxication. Acute systemic mild hypohydration or dehydration may be a pathogenic factor in oligohydramnios (IIa), prolonged labor (IIa), cystic fibrosis (III), hypertonic dehydration (III), and renal toxicity of xenobiotica (Ib). Maintaining good hydration status has been shown to positively affect urolithiasis (Ib) and may be beneficial in treating urinary tract infection (IIb), constipation (III), hypertension (III), venous thromboembolism (III), fatal coronary heart disease (III), stroke (III), dental disease (IV), hyperosmolar hyperglycemic diabetic ketoacidosis (IIb), gallstone disease (III), mitral valve prolapse (IIb), and glaucoma (III). Local mild hypohydration or dehydration may play a critical role in the pathogenesis of several broncho-pulmonary disorders like exercise asthma (IIb) or cystic fibrosis (Ib). In bladder and colon cancers, the evidence on hydration status' effects is inconsistent.

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Renal Stone Risk in a Simulated Microgravity Environment: Impact of Treadmill Exercise With Lower Body Negative Pressure

Cited by 26 publications

References 12 publications

Sex‐specific responses of bone metabolism and renal stone risk during bed rest

Sex‐specific responses of bone metabolism and renal stone risk during bed rest

Space Flight Calcium: Implications for Astronaut Health, Spacecraft Operations, and Earth

Hydration and Disease

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