Renal safety of catheter-based renal denervation: systematic review and meta-analysis

Abstract

Based on meta-analyses of 52 studies and a qualitative review of an additional 14 studies, reporting on 2898 patients in total, we conclude that renal function does not significantly change up to at least 9 months after RDN.

Renal Denervation for Resistant Hypertension in the Contemporary Era: A Systematic Review and Meta-Analysis

“…We have also shown that patients who underwent RDN had no significant changes in renal function (eGFR) compared to the medical therapy group at 6 months post-renal denervation, supporting the safety profile of the procedure. Our findings are consistent with prior published studies 6,29 . The positive results noted in the newer trials did not affect the overall result of the meta-analysis.…”

Kidney function and markers of renal damage after renal denervation. Does method of measurement matter? The Reshape CV‐Risk Study

“…Previously published studies in humans have concluded that RDN is generally safe in terms of kidney structure and function assessed as eGFR, both in the short and long term 12,16,19,32 . However, our study on patients with TRHT and relatively well‐preserved kidney function at baseline suggests that a clinically significant GFR decline may occur.…”

Safety of surgical denervation of the common hepatic artery in insulin‐resistant dogs

“…Multiple clinical trials are underway to test the effect of catheter‐based renal denervation in obese, drug‐resistant cases of hypertension (Mahfoud et al, 2011). These cohorts suggested that renal denervation is safe (Kandzari et al, 2018; Sanders et al, 2017). The primary safety end point was most often a composite of death, end‐stage renal disease, embolic events resulting in end‐organ damage, and renovascular complications.…”