Renal Responses to “Light” Methoxyflurane Anesthesia

Hetrick, W D; Wolfson, Bernard; Garcia, DO; Siker, Ephraim S.

doi:10.1097/00000542-197301000-00009

Cited by 23 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 No evidence of methoxyflurane-induced renal toxicity, either clinical or biochemical, was ever found when it was used for procedural analgesia in the short term at low doses. [18][19][20] Renal tubular dysfunction was observed after high cumulative doses of methoxyflurane from long duration inhalation anaesthesia in a retrospective setting only. 18,21 Numerous studies have shown no adverse effects to multiple exposures of methoxyflurane.…”

Section: Discussionmentioning

confidence: 98%

“…[18][19][20] Renal tubular dysfunction was observed after high cumulative doses of methoxyflurane from long duration inhalation anaesthesia in a retrospective setting only. 18,21 Numerous studies have shown no adverse effects to multiple exposures of methoxyflurane. [13][14][15][16] Firn's study exposed children to methoxyflurane between one and thirteen times with no complications.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Use of methoxyflurane for paediatric patients in a regional burn service outpatient clinic

Wall

Clarke

Smith

et al. 2020

Southern African Journal of Anaesthesia and Analgesia

View full text Add to dashboard Cite

Background: Procedural analgesia is essential for burn-injured patients. Ketamine is the cornerstone of many procedural analgesia protocols for children as it is safe and effective. However, it requires monitoring and the child may remain sedated for a number of hours. We sought an alternative analgesic option. Methoxyflurane is an inhalational analgesic with rapid onset of action for short term analgesia. There is little literature on the use of this drug in children in South Africa, particularly in burns patients. This paper describes our introduction of methoxyflurane into our procedural analgesia protocols for pain associated with dressing changes for paediatric burns. Methods: We performed a retrospective review of data from the burns database for a two-month period after the addition of methoxyflurane to the paediatric burn outpatient procedural analgesia protocol as the first line analgesia option. Results: Ninety-five children were reviewed in the clinic over the two-month period. Thirty patients did not require analgesia for their dressing changes. Methoxyflurane provided effective analgesia in 49/65 (75%) patients. Conclusion: This study has shown that methoxyflurane is a viable option for analgesia for burns dressing changes in a busy outpatient setting. It is an effective and safe alternative to ketamine. Further research is required into the use of methoxyflurane in other burns settings to clarify predictors of failure, ease of use and possible side effect profiles.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Use of methoxyflurane for paediatric patients in a regional burn service outpatient clinic

Wall

Clarke

Smith

et al. 2020

Southern African Journal of Anaesthesia and Analgesia

View full text Add to dashboard Cite

show abstract

“…A recent study (Hetrick et al, 1973) indicated that in patients exposed to "light" methoxyflurane anaesthesia, there was a significant reduction in urine osmolality, but the reduction was not signicantly different from that in a control group; it was concluded that fluoride derived from methoxyflurane might inhibit antidiuretic hormone as a doserelated phenomenon.…”

Section: Discussionmentioning

confidence: 98%