Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism

Iwakura, Yoshitsugu; Ito, Sadayoshi; Morimoto, Ryo; Kudo, Masataka; Ono, Yoshikiyo; Nezu, Masahiro; Takase, Kei; Seiji, Kazumasa; Ishidoya, Shigeto; Arai, Yoichi; Funamizu, Yasuharu; Miki, Takashi; Nakamura, Yasuhiro; Sasano, Hironobu; Satoh, Fumitoshi

doi:10.1161/hypertensionaha.115.05924

Cited by 18 publications

(10 citation statements)

References 31 publications

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“…16 The resistive indices of main, hilum, and interlobar arteries were significantly reduced 1 month after adrenalectomy and remained stable for 12 months. 16 The resistive indices of main, hilum, and interlobar arteries were significantly reduced 1 month after adrenalectomy and remained stable for 12 months.…”

Section: Rri and S Econdary Hyperten S I Onmentioning

confidence: 89%

“…Moreover, regarding the endocrine causes of secondary HTN, a recent study has shown that RRI was significantly higher in patients with aldosteronoma. 16 The resistive indices of main, hilum, and interlobar arteries were significantly reduced 1 month after adrenalectomy and remained stable for 12 months. Of note, the initial RRI was significantly associated with long-term postoperative resistant HTN.…”

Section: Rri and S Econdary Hyperten S I Onmentioning

confidence: 89%

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Renal resistive index in hypertensive patients

Andrikou

Tsioufis

Konstantinidis

et al. 2018

J of Clinical Hypertension

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Spectral Doppler ultrasonography provides the evaluation of renal resistive index (RRI), a noninvasive and reproducible measure to investigate arterial compliance and/or resistance. RRI seems to possess an important role in the evaluation of diverse cases of secondary hypertension. In essential hypertension, RRI is associated with subclinical markers of target organ damage and reflects renal disease progression beyond albuminuria and creatinine clearance. Also, RRI can estimate cardiovascular and renal risk. The evaluation of RRI may also help the therapeutic decisions. Given its simple assessment, RRI emerges as a simple method and a “multifunctional” tool that could help on the cardiovascular risk evaluation of the hypertensive patient.

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Section: Rri and S Econdary Hyperten S I Onmentioning

confidence: 89%

Section: Rri and S Econdary Hyperten S I Onmentioning

confidence: 89%

Renal resistive index in hypertensive patients

Andrikou

Tsioufis

Konstantinidis

et al. 2018

J of Clinical Hypertension

View full text Add to dashboard Cite

show abstract

“…In the present study, we observed that interlobar and arcuate artery resistive index values were significantly increased in type 2 diabetic patients compared with controls and also significantly increased values were observed in microalbuminuric diabetics compared with normoalbuminuric diabetics. A high renal RI may reflect increased stiffness of preglomerular arteries and increased intrarenal vascular resistance, including postglomerular circulation [27].…”

Section: Discussionmentioning

confidence: 99%

Renal resistive index and its association with insulin resistance in patients with Type 2 Diabetes mellitus

Santha¹,

K²,

K.K³

et al. 2017

IOSR JDMS

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“…Moreover, Chapman et al [34] showed that RRI is comparable in patients with EH and hypertensive ADPKD, and recently has been demonstrated that patients with PA have higher RRI, reversible after treatment. [48] The mechanisms by which aldosterone exerts its negative effect include an oxidative stress and an endothelial dysfunction through a decreased synthesis and release of nitric oxide, [27,49] the production of reactive oxygen species mediated by nicotinamide adenine dinucleotide phosphateoxidase-dependent mechanisms, [50] inflammation and fluid retention, determining vascular remodeling, hypertrophy, and fibrosis. [51–54] Furthermore, aldosterone seems also involved in the development of metabolic syndrome, dyslipidemia, and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease

et al. 2016

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Hypertension is commonly associated with autosomal dominant polycystic kidney disease (ADPKD), often discovered before the onset of renal failure, albeit the pathogenetic mechanisms are not well elucidated. Hyperaldosteronism in ADPKD may contribute to the development of insulin resistance and endothelial dysfunction, and progression of cardiorenal disease. The aim of study was to evaluate the prevalence of primary aldosteronism (PA) in ADPKD patients and identify some surrogate biomarkers of cardiovascular risk.We have enrolled 27 hypertensive ADPKD patients with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min, evaluating the renin–angiotensin–aldosterone system (RAAS), inflammatory indexes, nutritional status, homocysteine (Hcy), homeostasis model assessment-insulin resistance (HOMA-IR), mineral metabolism, microalbuminuria, and surrogate markers of atherosclerosis [carotid intima media thickness (cIMT), ankle/brachial index (ABI), flow mediated dilation (FMD), renal resistive index (RRI) and left ventricular mass index (LVMI)]. Furthermore, we have carried out the morpho-functional magnetic resonance imaging (MRI) with high-field 3 T Magnetom Avanto.We have divided patients into group A, with normal plasma aldosterone concentration (PAC) and group B with PA, present in 9 (33%) of overall ADPKD patients. Respect to group A, group B showed a significant higher mean value of LVMI, HOMA-IR and Hcy (P = 0.001, P = 0.004, P = 0.018; respectively), and a lower value of FMD and 25-hydroxyvitamin D (25-OH-VitD) (P = 0.037, P = 0.019; respectively) with a higher prevalence of non-dipper pattern at Ambulatory Blood Pressure Monitoring (ABPM) (65% vs 40%, P < 0.05) at an early stage of the disease.In this study, we showed a high prevalence of PA in ADPKD patients, associated to higher LVMI, HOMA-IR, Hcy, lower FMD, and 25-OH-VitD, considered as surrogate markers of atherosclerosis, compared to ADPKD patients with normal PAC values. Our results indicate a higher overall cardiovascular risk in ADPKD patients with inappropriate aldosterone secretion, and a screening for PA in all patients with ADPKD is recommended.

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Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism

Abstract: SummaryRemoval of aldosterone-producing adenoma reduces renal resistive index. Preoperative resistive index may predict blood pressure outcome after surgery. Early detection of primary aldosteronism is important for preventing organ damage.

Cited by 18 publications

References 31 publications

Renal resistive index in hypertensive patients

Renal resistive index in hypertensive patients

Renal resistive index and its association with insulin resistance in patients with Type 2 Diabetes mellitus

Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease

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