Renal protective and immunoregulatory effects of Lactobacillus casei strain Shirota in nephropathy-prone mice
Chun-Wai Chan,
Yu-Ting Chen,
Bi-Fong Lin
Abstract:IntroductionThe incidence of severe acute kidney injury (AKI) is considerably high worldwide. A previous study showed that gut microbial dysbiosis was a hallmark of AKI in mice. Whether the probiotic Lactobacillus casei strain Shirota (LcS) plays a role in kidney disease, particularly AKI, remains unclear.MethodsTo investigate the effects of LcS on kidney injury, tubule-specific conditional von Hippel–Lindau gene-knockout C57BL/6 mice (Vhlhdel/del mice) were supplemented without (Ctrl) or with probiotics (LcS)… Show more
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