Renal progenitor cells modulated by angiotensin II receptor blocker (ARB) medication and differentiation towards podocytes in anti-thy1.1 nephritis

Wu, Dayong; Bai, Jiuxu; Cui, Shaoyuan; Fu, Bo; Yin, Zhiwei; Cai, Guangyan; Chen, Xiangmei

doi:10.21037/atm.2020.02.58

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…Losartan may work on miR-193a via VDR upregulation. Also, losartan was shown to increase the number of renal progenitors and improve outcomes in a mouse model of mesangioproliferative glomerulonephritis [72].…”

Section: Mir-193a In Diabetic Nephropathymentioning

confidence: 99%

MicroRNA193a: An Emerging Mediator of Glomerular Diseases

Bharati,

Kumar,

Kumar

et al. 2023

Biomolecules

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MicroRNAs (miRNAs) are noncoding small RNAs that regulate the protein expression of coding messenger RNAs. They are used as biomarkers to aid in diagnosing, prognosticating, and surveillance of diseases, especially solid cancers. MiR-193a was shown to be directly pathogenic in an experimental mouse model of focal segmental glomerulosclerosis (FSGS) during the last decade. Its specific binding and downregulation of Wilm’s tumor-1 (WT-1), a transcription factor regulating podocyte phenotype, is documented. Also, miR-193a is a regulator switch causing the transdifferentiation of glomerular parietal epithelial cells to a podocyte phenotype in in vitro study. Interaction between miR-193a and apolipoprotein 1 (APOL1) mRNA in glomeruli (filtration units of kidneys) is potentially involved in the pathogenesis of common glomerular diseases. Since the last decade, there has been an increasing interest in the role of miR-193a in glomerular diseases, including diabetic nephropathy and membranous nephropathy, besides FSGS. Considering the lack of biomarkers to manage FSGS and diabetic nephropathy clinically, it is worthwhile to invest in evaluating miR-193a in the pathogenesis of these diseases. What causes the upregulation of miR-193a in FSGS and how the mechanism is different in different glomerular disorders still need to be elucidated. This narrative review highlights the pathogenic mechanisms of miR-193a elevation in various glomerular diseases and its potential use in clinical management.

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Section: Mir-193a In Diabetic Nephropathymentioning

confidence: 99%

MicroRNA193a: An Emerging Mediator of Glomerular Diseases

Bharati,

Kumar,

Kumar

et al. 2023

Biomolecules

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“…These results provide another explanation to the beneficial effects observed after the angiotensin II receptor blocker (ARB) treatment. Similarly, the ARB treatment improved the outcome in a rat model of mesangial proliferative glomerulonephritis, inducing an increase in the number of PECs expressing stem cell markers [ 38 ].…”

Section: Renal Progenitorsmentioning

confidence: 99%

Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?

Peired

Melica

Molli

et al. 2021

Cells

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Kidneys of mice, rats and humans possess progenitors that maintain daily homeostasis and take part in endogenous regenerative processes following injury, owing to their capacity to proliferate and differentiate. In the glomerular and tubular compartments of the nephron, consistent studies demonstrated that well-characterized, distinct populations of progenitor cells, localized in the parietal epithelium of Bowman capsule and scattered in the proximal and distal tubules, could generate segment-specific cells in physiological conditions and following tissue injury. However, defective or abnormal regenerative responses of these progenitors can contribute to pathologic conditions. The molecular characteristics of renal progenitors have been extensively studied, revealing that numerous classical and evolutionarily conserved pathways, such as Notch or Wnt/β-catenin, play a major role in cell regulation. Others, such as retinoic acid, renin-angiotensin-aldosterone system, TLR2 (Toll-like receptor 2) and leptin, are also important in this process. In this review, we summarize the plethora of molecular mechanisms directing renal progenitor responses during homeostasis and following kidney injury. Finally, we will explore how single-cell RNA sequencing could bring the characterization of renal progenitors to the next level, while knowing their molecular signature is gaining relevance in the clinic.

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“…In the article entitled "Renal progenitor cells modulated by angiotensin II receptor blocker (ARB) medication and differentiation towards podocytes in anti-thy1.1 nephritis" (1), there are some errors.…”

mentioning

confidence: 99%